A Hydrogel Dressing Comprised of Silk Fibroin, Ag Nanoparticles, and Reduced Graphene Oxide for NIR Photothermal‐Enhanced Antibacterial Efficiency and Skin Regeneration

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Bacterial infection, inflammation, and excessive oxidative stress are the primary factors that contribute to delayed healing of skin wounds. In this study, a multifunctional wound dressing (SF/Ag@rGO hydrogel) is developed promote infected wounds by combining inherent antibacterial activity Ag nanoparticles (NPs) with near-infrared (NIR)-assisted therapy. Initially, L-ascorbic acid used as reducing agent PVP-K17 stabilizer dispersant, facilitates synthesis reduced graphene oxide loaded NPs (Ag@rGO). Ag@rGO then blended silk fibroin (SF) solution form an instantly gelling SF/Ag@rGO hydrogel exhibits rapid self-healing, injectability, shape adaptability, NIR responsiveness, antioxidant, high tissue adhesion, robust mechanical properties. vitro in vivo experiments show demonstrates strong antioxidant photothermal capabilities, promoting through angiogenesis, stimulating collagen generation, alleviating cell proliferation, indicating ideal candidate for clinical treatment full-thickness bacterial-stained

Language: Английский

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A microenvironment-modulating dressing with proliferative degradants for the healing of diabetic wounds

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 12, 2024

Diabetic wounds are usually entangled in a disorganized and self-perpetuating microenvironment accompanied by prolonged delay tissue repair. Sustained coordinated regulation regeneration key to the healing process of diabetic wounds, yet they continue pose formidable challenge. Here we report rational double-layered dressing design based on chitosan degradable conjugated polymer polydiacetylene, poly(deca-4,6-diynedioic acid) (PDDA), that can meet this intricate requirement. With an alternating ene-yne backbone, PDDA degrades when reacting with various types reactive oxygen species (ROS), more importantly, generates proliferative succinic acid as major degradant. Inheriting from PDDA, developed PDDA-chitosan double layer (PCD) eliminate ROS alleviate inflammation, downregulate gene expression innate immune receptors. PCD degradation also triggers simultaneous release sustainable manner, enabling long-term promotion regeneration. We have validated biocompatibility excellent performance expediting wound both mouse porcine models, which underscores significant translational potential microenvironment-modulating, growth-promoting care. vital for but elusive. Here, authors double-layered, microenvironment-modulating able generate degradants promote angiogenesis wounds.

Language: Английский

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Towards promoting wound healing: A near-infrared light-triggered persistently antibacterial, synergistically hemostatic nanoarchitecture-integrated chitosan hydrogel

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 329, P. 121783 - 121783

Published: Jan. 8, 2024

Language: Английский

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Recent advances in fabrication of dECM-based composite materials for skin tissue engineering

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 23, 2024

Chronic wound management is an intractable medical and social problem, affecting the health of millions worldwide. Decellularized extracellular matrix (dECM)-based materials possess remarkable biological properties for tissue regeneration, which have been used as commercial products skin regeneration in clinics. However, complex external environment longer chronic wound-healing process hinder application pure dECM materials. dECM-based composite are constructed to promote healing different wounds, showing noteworthy functions, such anti-microbial activity suitable degradability. Moreover, fabrication technologies designing dressings with various forms expanded This review provides a summary recent building materials, highlighting advances molded hydrogels, electrospun fibers, bio-printed scaffolds managing wounds. The associated challenges prospects clinical finally discussed.

Language: Английский

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Advancements in nanozymes research for the management of chronic wounds

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157299 - 157299

Published: Nov. 1, 2024

Language: Английский

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Metal‐Protein Hybrid Materials: Unlocking New Frontiers in Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Metal‐protein hybrid materials represent a novel class of functional that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including engineering, biocatalysis, biosensing, biomedicine. The design development multifunctional biocompatible metal‐protein have been the subject extensive research key aspiration for practical clinical settings. This review provides comprehensive analysis strategies, intrinsic properties, biomedical these materials, with specific emphasis on their potential cancer therapy, drug vaccine delivery, antibacterial treatments, tissue regeneration. Through rational design, stable can be synthesized using straightforward methods, enabling therapeutic, immunomodulatory, other desired functionalities. Finally, outlines existing limitations challenges associated evaluates translation, providing insights into implementation within applications.

Language: Английский

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Porphyrin-graphdiyne analogue modified MXene nanosheets for highly efficient, stable and long-term antibacterials

Next Materials, Journal Year: 2025, Volume and Issue: 6, P. 100485 - 100485

Published: Jan. 1, 2025

Language: Английский

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Engineered Au@MOFs silk fibroin-based hydrogel phototherapy platform for enhanced wound healing performance

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 297, P. 139872 - 139872

Published: Jan. 14, 2025

Language: Английский

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A 3-in-1 wearable and implantable biopatch for integrated in-body energy harvesting, sensing, and self-powered diabetic wound treatments

Nano Energy, Journal Year: 2025, Volume and Issue: unknown, P. 110743 - 110743

Published: Feb. 1, 2025

Language: Английский

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Double‐Edged Dissolving Microneedle Patches Loaded with Zn/Ce Composites and Vancomycin for Treatment of Drug‐Resistant Bacterial Infected Skin Abscess

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

The management of abscess wounds induced by antibiotic-resistant bacterial infections has become increasingly formidable due to the widespread overutilization and misuse antimicrobial agents. This study presents an innovative dissolvable microneedle (MN) patch incorporating Au@ZnO/Ce nanocomposites vancomycin (AZC/Van@MN), exhibiting robust anti-inflammatory properties, meticulously engineered for therapeutic intervention wounds. developed AZC/Van@MN demonstrates exceptional biocompatibility as evidenced comprehensive histopathological hematological assessments. It effectively eradicates colonies through synergistic action Van mild photothermal therapy (PTT, ≤42 °C). Transcriptomic analysis elucidates that antibacterial mechanism involves upregulation riboflavin biosynthesis suppression arginine pathways. Furthermore, significantly reduces dimensions, load, inflammatory response, while simultaneously enhancing wound healing via accelerated re-epithelialization angiogenesis. double-edged MN represents a promising strategy combating skin abscesses instigated bacteria.

Language: Английский

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