Advancements in Protein-Based Bionanocomposites for Targeted and Controlled Drug Delivery Systems: A Comprehensive Review

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106698 - 106698

Published: Feb. 1, 2025

Language: Английский

---

Injectable Inflammation‐Responsive Hydrogels for Microenvironmental Regulation of Intervertebral Disc Degeneration

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: April 22, 2024

Chronic local inflammation and excessive cell apoptosis in nucleus pulposus (NP) tissue are the main causes of intervertebral disc degeneration (IDD). Stimuli-responsive hydrogels have great potential treatment IDD by facilitating localized controlled drug delivery. Herein, an injectable drug-loaded dual stimuli-responsive adhesive hydrogel for microenvironmental regulation IDD, is developed. The gelatin methacryloyl functionalized with phenylboronic acid groups to enhance loading capacity enable behavior, while incorporation oxidized hyaluronic further improves properties. prepared exhibits enhanced diol-containing drugs, pH- reactive oxygen species (ROS)-responsive behaviors, excellent radical scavenging efficiency, potent antibacterial activity, favorable biocompatibility. Furthermore, shows a beneficial protective efficacy on NP cells within vitro oxidative stress microenvironment. vivo results demonstrate hydrogel's therapeutic effect treating maintaining water retention, restoring height, promoting regeneration, indicating that this holds as promising approach regulating microenvironment alleviating progression IDD.

Language: Английский

---

A review of 3D bioprinting for organoids

Medical Review, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Current two-dimensional (2D) cell models for effective drug screening suffer from significant limitations imposed by the lack of realism in physiological environment. Three-dimensional (3D) organoids hold immense potential mimicking key functions human organs overcoming traditional 2D models. However, current techniques preparation 3D had reproducibility, scalability, and ability to closely replicate complex microenvironment found vivo . Additionally, culture systems often involve lengthy labor-intensive processes that hinder high-throughput applications necessary a large-scale screening. Advancements bioprinting technologies offer promising solutions these challenges enabling precise spatial control over placement material composition, thereby facilitating creation more physiologically relevant than techniques. This review provides comprehensive summary recent advances creating models, which begins with an introduction different types (especially focus on volumetric (VBP) technique), followed overview bioinks utilized bioprinting. Moreover, we also introduce disease efficiency evaluation regenerative medicine. Finally, possible strategies development clinical translation are concluded.

Language: Английский

---

Multifunctional Bionanocomposite Hydrogels based on Gelatin Methacrylate and Polyphenolic 2D Nanoparticles Decorated with Antimicrobial Bis(imidazolium)-based Ionic Liquids

Composites Science and Technology, Journal Year: 2025, Volume and Issue: 262, P. 111059 - 111059

Published: Jan. 20, 2025

Language: Английский

---

3D pancreatic ductal adenocarcinoma desmoplastic model: Glycolysis facilitating stemness via ITGAV-PI3K-AKT-YAP1

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 170, P. 214215 - 214215

Published: Jan. 29, 2025

Language: Английский

---

3D-printed Multifunctional Bilayer Scaffold with Sustained Release of Apoptotic Extracellular Vesicles and Antibacterial Coacervates for Enhanced Wound Healing

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123196 - 123196

Published: Feb. 15, 2025

Language: Английский

---

Predicting Rheological Properties of HAMA/GelMA Hybrid Hydrogels via Machine Learning

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2025, Volume and Issue: 168, P. 107005 - 107005

Published: April 11, 2025

Language: Английский

---

Enhancement of alginate/gelatin/polyvinyl alcohol hydrogels for multi-crosslinked 3D printed blood vessels

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 142947 - 142947

Published: April 19, 2025

Language: Английский

---

Hydrogels for Cardio and Vascular Tissue Repair and Regeneration

Gels, Journal Year: 2024, Volume and Issue: 10(3), P. 196 - 196

Published: March 13, 2024

Cardiovascular disease (CVD), the leading cause of death globally, affects heart and arteries with a variety clinical manifestations, most dramatic which are myocardial infarction (MI), abdominal aortic aneurysm (AAA), intracranial (IA) rupture. In MI, necrosis myocardium, scar formation, loss cardiomyocytes result from insufficient blood supply due to coronary artery occlusion. Beyond stenosis, that structurally functionally connected cardiac tissue can undergo pathological dilation, i.e., aneurysmal high risk Aneurysms (IAs) more commonly seen in young adults, whereas those aorta (AAA) predominantly elderly. IAs, unpredictably, rupture life-threatening hemorrhage, while AAAs rupture, internal bleeding mortality rate. this context, hydrogels, three-dimensional networks water-seizing polymers, have emerged as promising biomaterials for cardiovascular repair or protection their biocompatibility, tunable properties, ability encapsulate release bioactive molecules. This review provides an overview current state research on use hydrogels innovative platform promote cardiovascular-specific MI functional recovery dilation.

Language: Английский

---

Integration of Hydrogels and 3D Bioprinting Technologies for Chronic Wound Healing Management

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

The integration of hydrogel-based bioinks with 3D bioprinting technologies presents an innovative approach to chronic wound management, which is particularly challenging treat because its multifactorial nature and high risk complications. Using precise deposition techniques, significantly alters traditional care paradigms by enabling the fabrication patient-specific dressings that imitate natural tissue properties. Hydrogels are notably beneficial for these applications their abundant water content mechanical properties, promote cell viability pathophysiological processes healing, such as re-epithelialization angiogenesis. This article reviews key printing significance in enhancing structural functional outcomes wound-care solutions. Challenges bioink viscosity, viability, printability addressed, along discussions on cross-linking stability constructs. potential revolutionize management rests capacity generate remedies expedite healing minimize infection risks. Nevertheless, further studies clinical trials necessary advance therapies from laboratory use.

Language: Английский

---