Advancements in nanoparticle-based vaccine development against Japanese encephalitis virus: a systematic review DOI Creative Commons

Takele Adugna,

Qingli Niu,

Guiquan Guan

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 20, 2024

Vaccination remains the sole effective strategy for combating Japanese encephalitis (JE). Both inactivated and live attenuated vaccines exhibit robust immunogenicity. However, production of these conventional vaccine modalities necessitates extensive cultivation pathogen, incurring substantial costs presenting significant biosafety risks. Moreover, administration pathogens poses potential hazards individuals or animals with compromised immune systems other health vulnerabilities. Subsequently, ongoing research endeavors are focused on development next-generation JE utilizing nanoparticle (NP) platforms. This systematic review seeks to aggregate findings pertaining NP-based against JE. A thorough literature search was conducted across established English-language databases articles NP published between 2000 2023. total twenty-eight studies were selected detailed analysis in this review. Of these, 16 (57.14%) concentrated virus-like particles (VLPs) employing various structural proteins. Other approaches, including sub-viral (SVPs), biopolymers, both synthetic inorganic platforms, utilized a lesser extent. The results investigations indicated that, despite variations usage adjuvants, dosages, types, antigenic proteins, animal models employed different studies, candidate developed capable eliciting enhanced humoral cellular adaptive responses, providing protection (70-100%) immunized mice lethal challenges posed by virulent virus (JEV). In conclusion, prospective humans may emerge from formulations following further evaluation subsequent phases.

Language: Английский

Inhalable Nano Formulation of Cabazitaxel: A Comparative Study with Intravenous Route DOI Creative Commons
Elif Kağa, Sadık Kağa,

Korhan Altunbas

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract Chemotherapy is generally given by intravenous (IV) administration which provides higher bioavailability than other systemic routes. However, in the case of lung cancer, pulmonary (INH) route choice for inhalable formulations. In study, biochemical and histological parameters Cabazitaxel (CBZ) free (2 mg kg −1 ) nanoparticle (NP) CBZ equivalent) formulations are investigated after IV INH rats. The nanoformulation obtained using PEGylated polystyrene (PEG‐PST) nanoparticles PISA. While a nose head‐only device used administration, jugular vein as route. Blood samples (blank, 24 h, 48 h) collected via carotid artery cannulas without handling metabolism cages. According to parameters, formulation applied or shows toxicity. On hand, showed no signs toxicity both Higher longer retention observed inhaled nanoformulation. Histological analysis alveolar macrophage migration due enhanced retention. Results that nanotechnology defense system gave advantage end up with an nanomedicine cancer.

Language: Английский

Citations

1
Understanding nanoparticle-liver interactions in nanomedicine DOI
Yuxin He, Yifan Wang, Lin Wang

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(6), P. 829 - 843

Published: June 2, 2024

Introduction Understanding the interactions between administered nanoparticles and liver is crucial for developing safe effective nanomedicines. As can sequester up to 99% of these particles due its major phagocytic role, exploring vital clinical translation.

Language: Английский

Citations

5
PEGylation technology: addressing concerns, moving forward DOI Creative Commons
Dmitri Simberg,

Yechezkel Barenholz,

Steve R. Roffler

et al.

Drug Delivery, Journal Year: 2025, Volume and Issue: 32(1)

Published: April 23, 2025

PEGylation technology, that is grafting of poly(ethylene glycol)(PEG) to biologics, vaccines and nanopharmaceuticals, has become a cornerstone modern medicines with over thirty products used in the clinic. therapeutic proteins, nucleic acids nanopharmaceuticals improves their stability, pharmacokinetic biodistribution. While PEGylated are safe majority patients, there growing concerns about emergence anti-PEG antibodies impact on efficacy as well broader immune responses, particularly complement activation hypersensitivity reactions. These beginning scrutinize future viability technology medicine design. Here, we outline these concerns, encourage more efforts into looking for comprehensive scientific evidence role reactions, discuss alternatives PEG propose strategies moving forward.

Language: Английский

Citations

0
Design and Biodistribution of PEGylated Core–Shell X-ray Fluorescent Nanoparticle Contrast Agents DOI Creative Commons
Giovanni Marco Saladino, Bertha Brodin,

Mihai Ciobanu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Nanoparticle (NP) uptake by macrophages and their accumulation in undesired organs such as the liver spleen constitute a major barrier to effective delivery of NPs targeted tissues for bioimaging therapeutics. Surface functionalization with polyethylene glycol (PEG) has been demonstrated be promising strategy limit NP sequestration, although its longitudinal stability under physiological conditions impact on biodistribution have not investigated an vivo quantitative approach. X-ray fluorescence (XRF) imaging employed noninvasively map purposely designed molybdenum-based contrast agents, leading submillimeter resolution, elemental specificity, high penetration depth. In present work, we design stepwise layering approach synthesis investigate role chemisorbed physisorbed PEG silica-coated agents affecting biodistribution, using whole-body XRF imaging. Comparative studies indicated that (1.5 kDa) did substantially affect while chemisorption route mPEG-Si (6-9 units) led significant macroscopic variations reduction liver. Furthermore, results highlighted compensating limited sequestration liver, microscopically validated multiscale fluorophore doping silica shell. These findings rapid assessment surface-functionalized pharmacokinetic studies, establishing groundwork developing strategies identify bypass uptake.

Language: Английский

Citations

0
Nanotechnology Assisted Drug Delivery Strategies for Chemotherapy: Recent Advances and Future Prospects DOI
Pavan Kumar Yadav, Divya Chauhan, Pooja Yadav

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

In pursuit of the treatment cancer, nanotechnology engineering has emerged as simplest and most effective means, with potential to deliver antitumor chemotherapeutics at targeted site. Employing for drug delivery provides diverse nanosize particles ranging from one a thousand nanometers. Reduced size improves bioavailability by increasing diffusion decreasing efflux rate. These nanocarriers offer an enormous scope modification following chemical biological properties both its disease. Moreover, these nanoformulations assist in targeting pharmaceutically active molecules desired site have gained importance recent years. Their modern use revolutionized action many therapeutic agents. Higher loading efficiency, thermal stability, easy fabrication, low production cost, large-scale industrial draw attention application better platform molecules. Furthermore, interaction nanocarrier technology-assisted agents lowers drug's toxicity dosage, reduces tolerance, enhances concentration neoplasm tissue, thus healthy tissue. Nanotechnology-based medications are being widely explored depicted cancer management vivo vitro systems, leading clinical trials promising results. This review summarizes innovative impact different developed years therapy. Subsequently, it also describes essential findings methodologies their effects on treatment. Compared conventional therapy, nanomedicines can significantly improve effectiveness drugs. Thus, adverse associated tissues decreased, scaled back through enhanced permeability retention effects. Lastly, future insights assisting therapeutics been discussed.

Language: Английский

Citations

0
Entry of nanoparticles into cells and tissues: status and challenges DOI Creative Commons
Kirsten Sandvig, Tore‐Geir Iversen, Tore Skotland

et al.

Beilstein Journal of Nanotechnology, Journal Year: 2024, Volume and Issue: 15, P. 1017 - 1029

Published: Aug. 12, 2024

In this article we discuss how nanoparticles (NPs) of different compositions may interact with and be internalized by cells, the consequences that for cellular functions. A large number NPs are made intention to improve cancer treatment, goal being increase fraction injected drug delivered tumor thereby therapeutic effect decrease side effects. Thus, tumors some challenges related investigations biodistribution, pharmacokinetics, excretion. Finally, requirements bringing into clinical use aspects when it comes usage complex slowly degraded or nondegradable NPs.

Language: Английский

Citations

2
Age-dependent changes in phagocytic activity: in vivo response of mouse pulmonary antigen presenting cells to direct lung delivery of charged PEGDA nanoparticles DOI Creative Commons
Emma R. Sudduth, Aida López Ruiz, Michael Trautmann-Rodriguez

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 12, 2024

Current needle-based vaccination for respiratory viruses is ineffective at producing sufficient, long-lasting local immunity in the elderly. Direct pulmonary delivery to resident immune cells can create long-term mucosal responses. However, criteria drug vehicle design rules that overcome age-specific changes cell functions have yet be established.

Language: Английский

Citations

0
PEGylated lipid polymeric nanoparticles for management of rheumatoid arthritis DOI
Moataz B. Zewail, Gihan F. Asaad, Marwa E. Shabana

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106242 - 106242

Published: Sept. 1, 2024

Language: Английский

Citations

0
Polyethylene Glycols Stimulate Ca2+ Signaling, Cytokine Production, and the Formation of Neutrophil Extracellular Traps DOI Creative Commons
Alicja Hinz, Sylwia Stankiewicz,

Jacek Litewka

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13165 - 13181

Published: Dec. 1, 2024

Given the increased use of polyethylene glycol (PEG) in refining therapeutic activity medicines, our research focuses on explaining potential mechanism immune reactions associated with this polymer. We aim to investigate interaction different types PEG mouse and human cells, thereby contributing understanding interactions system verifying proinflammatory tested polymers.

Language: Английский

Citations

0
Advancements in nanoparticle-based vaccine development against Japanese encephalitis virus: a systematic review DOI Creative Commons

Takele Adugna,

Qingli Niu,

Guiquan Guan

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 20, 2024

Vaccination remains the sole effective strategy for combating Japanese encephalitis (JE). Both inactivated and live attenuated vaccines exhibit robust immunogenicity. However, production of these conventional vaccine modalities necessitates extensive cultivation pathogen, incurring substantial costs presenting significant biosafety risks. Moreover, administration pathogens poses potential hazards individuals or animals with compromised immune systems other health vulnerabilities. Subsequently, ongoing research endeavors are focused on development next-generation JE utilizing nanoparticle (NP) platforms. This systematic review seeks to aggregate findings pertaining NP-based against JE. A thorough literature search was conducted across established English-language databases articles NP published between 2000 2023. total twenty-eight studies were selected detailed analysis in this review. Of these, 16 (57.14%) concentrated virus-like particles (VLPs) employing various structural proteins. Other approaches, including sub-viral (SVPs), biopolymers, both synthetic inorganic platforms, utilized a lesser extent. The results investigations indicated that, despite variations usage adjuvants, dosages, types, antigenic proteins, animal models employed different studies, candidate developed capable eliciting enhanced humoral cellular adaptive responses, providing protection (70-100%) immunized mice lethal challenges posed by virulent virus (JEV). In conclusion, prospective humans may emerge from formulations following further evaluation subsequent phases.

Language: Английский

Citations

0