Bio-Medical Materials and Engineering,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 13, 2024
Background
Mesenchymal
stem
cells-derived
exosomes,
crucial
in
regenerative
medicine,
have
been
explored
for
their
potential
the
functional
modification
of
bone
scaffolds.
Objective
To
design
a
functionally
modified
biomimetic
nanohydroxyapatite
using
exosomes
and
explore
its
effects
on
regeneration.
Methods
A
(named
as
tHA)
was
fabricated
previous
methods
polydopamine
(pDA)
structure
template,
(Exo)
derived
from
periodontal
ligament
cells
(PDLSCs)
were
used
to
modify
tHA
scaffold
material
through
pDA.
The
composite
(tHA-Exo)
proliferation
osteogenic
differentiation
investigated.
Furthermore,
effect
regeneration
also
evaluated
vivo.
Results
Exosomes
can
be
loaded
onto
via
pDA
tHA-Exo
releases
sustained
stable
manner.
showed
improved
cytocompatibility
compared
controls.
Additionally,
significantly
enhanced
PDLSCs.
More
importantly,
animal
experiments
shown
that
could
dramatically
promote
Conclusion
nanoparticles,
by
PDLSCs-Exo
pDA,
promoted
improving
potential,
which
serve
promising
promoting
Materials,
Journal Year:
2024,
Volume and Issue:
17(5), P. 1088 - 1088
Published: Feb. 27, 2024
From
1990
to
2024,
this
study
presents
a
groundbreaking
bibliometric
and
sentiment
analysis
of
nanocomposite
literature,
distinguishing
itself
from
existing
reviews
through
its
unique
computational
methodology.
Developed
by
our
research
group,
novel
approach
systematically
investigates
the
evolution
nanocomposites,
focusing
on
microstructural
characterization,
electrical
properties,
mechanical
behaviors.
By
deploying
advanced
Boolean
search
strategies
within
Scopus
database,
we
achieve
meticulous
extraction
in-depth
exploration
thematic
content,
methodological
advancement
in
field.
Our
uniquely
identifies
critical
trends
insights
concerning
microstructure,
attributes,
performance.
The
paper
goes
beyond
traditional
textual
analytics
evaluation,
offering
new
interpretations
data
highlighting
significant
collaborative
efforts
influential
studies
domain.
findings
uncover
language,
shifts,
global
contributions,
providing
distinct
comprehensive
view
dynamic
research.
A
component
is
“State-of-the-Art
Gaps
Extracted
Results
Discussions”
section,
which
delves
into
latest
advancements
This
section
details
various
types
their
properties
introduces
applications,
especially
films.
tracing
historical
progress
identifying
emerging
trends,
emphasizes
significance
collaboration
molding
Moreover,
“Literature
Review
Guided
Artificial
Intelligence”
showcases
an
innovative
AI-guided
research,
first
Focusing
articles
2023,
selected
based
citation
frequency,
method
offers
perspective
interplay
between
nanocomposites
properties.
It
highlights
composition,
structure,
functionality
systems,
integrating
recent
for
overview
current
knowledge.
analysis,
with
average
score
0.638771,
reflects
positive
trend
academic
discourse
increasing
recognition
potential
nanocomposites.
another
novelty,
maps
intellectual
domain,
emphasizing
pivotal
themes
influence
crosslinking
time
attributes.
While
acknowledging
limitations,
exemplifies
indispensable
role
tools
synthesizing
understanding
extensive
body
literature.
work
not
only
elucidates
prevailing
but
also
contributes
insights,
enhancing
Cureus,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 22, 2025
Erectile
dysfunction
(ED)
is
a
common
condition
in
men,
driven
by
complex
interplay
of
organic,
relational,
and
psychological
factors,
necessitating
an
integrated
treatment
approach.
Psychological
such
as
anxiety,
depression,
stress,
are
significant
contributors
to
erectile
problems.
can
have
severe
consequences,
including
feelings
emasculation,
humiliation,
reduced
self-confidence,
isolation,
loneliness,
decline
overall
well-being.
A
national
advisory
board
comprising
12
experts
from
India,
9
urologists
3
psychiatrists,
convened
discuss
multidisciplinary
approach
the
ED.
Using
modified
Delphi
method
literature
review,
34
panels
developed
evidence-based
insights.
Experts
highlighted
importance
thorough
assessments
sexual
patients.
Given
frequent
comorbidity
mental
health
issues
with
ED,
physicians
should
proactively
explore
patients'
health.
Creating
secure
welcoming
environment
crucial
for
these
assessments.
Physicians
gather
detailed
information
on
symptoms,
stressors,
relationship
dynamics,
cognitive
style,
distractions.
diagnostic
recommended
integrating
pharmacological
interventions
(e.g.,
phosphodiesterase-5
inhibitors)
psychometric
therapy,
tailored
age,
existing
comorbidities,
underlying
causes
balanced,
interdisciplinary
incorporating
psychosexual
lifestyle
modifications,
advanced
therapies
holistic
management
Key
consensus
recommendations
also
emphasized
fostering
open
communication
between
patients
healthcare
providers,
routine
screenings
early
referrals
specialists
when
necessary.
Clinicians
actively
involve
professionals
ED
prioritize
individualized
strategies
each
patient's
needs.
This
multifactorial
requires
coordinated
efforts
address
both
organic
psychogenic
causes,
restore
quality
life,
promote
communication.
By
engaging
patients,
addressing
their
concerns,
facilitating
needed,
clinicians
significantly
improve
outcomes
Journal of Cerebral Blood Flow & Metabolism,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Stem
cell-based
therapies
have
raised
considerable
interest
to
develop
regenerative
treatment
for
neurological
disorders
with
high
disability.
In
this
review,
we
focus
on
recent
preclinical
and
clinical
evidence
of
stem
cell
therapy
in
the
degenerative
diseases
discuss
different
types,
delivery
routes
biodistribution
therapy.
addition,
advances
mechanistic
insights
therapy,
including
functional
replacement
by
exogenous
cells,
immunomodulation
paracrine
effects
are
also
demonstrated.
Finally,
highlight
adjunction
approaches
that
has
been
implemented
augment
their
reparative
function,
survival
migration
target
specific
tissue,
preconditioning,
genetical
engineering,
co-transplantation
combined
Scaffolds
that
mimic
the
extracellular
matrix
(ECM)
can
promote
proliferation
of
stem
cells.
Poly(N-isopropylacrylamide)
(PNIPAM)/gelatin
(PG)
nanogel
electrospun
membranes
were
designed
to
replicate
hierarchical
and
dynamic
nature
ECMs.
First,
PG
nanogels
with
semi-interpenetrating
network
structures
synthesized
by
emulsion
polymerization.
Characterization
using
1H
NMR
FTIR
spectroscopies
confirmed
successful
incorporation
gelatin
into
PNIPAM-based
network.
The
spherical
a
size
184.1–231.9
nm,
they
demonstrated
thermoresponsive
behavior.
rehydrated
nanofibers
exhibited
an
average
diameter
663.6
±
50.1
nm
Young's
modulus
1.3
0.1
MPa
at
37
°C.
membrane
completely
degraded
within
10
min
collagenase
treatment.
Adipose-derived
cells
from
rats
good
on
membranes,
cell
in
PNI50
group
being
1.47
times
tissue
culture
plate
(TCP)
group.
showed
potential
for
expansion.
International Journal of Scientific Research in Science and Technology,
Journal Year:
2025,
Volume and Issue:
12(1), P. 531 - 543
Published: Feb. 13, 2025
Synthetic
molecules
derived
from
mesenchymal
stem
cells
(MSCs)
and
MSC-derived
exosomes
show
promise
as
regenerative
potential
for
tissue
repair
wound
healing.
MSCs
are
multipotent
can
differentiate
into
different
cell
types,
the
effect
of
which
is
enhanced
through
exosomes,
via
paracrine
signalling.
Guillamat-Prats
(2021)
concludes
recent
studies
have
shown
that
accelerate
healing
by
up
to
50%
compared
control
groups,
MSC
doubled
cellular
migration
collagen
deposition
in
vitro.
Additionally,
therapies
been
able
dramatically
decrease
inflammatory
cytokines
like
TNFα
IL6
40%,
leading
a
more
environmentally
favorable
milieu
(Lee
et
al.,
2023).
The
aim
this
study
investigate
effects
exosome
treatments
on
healing,
specifically
properties
immune
modulation
exosomes.
Although
results
were
subjective,
histological
analysis
showed
highest
improvement
closure
was
achieved
with
MSC+Exosome
treatments,
healed
over
95%
after
14
days,
while
groups
60%.
Finally,
demonstrates
utility
based
delivery
systems
targeted,
efficient
off
target
free
repair.
encouraging,
but
there
still
challenges,
including
scalability
rejection,
future
research
will
be
aimed
at
improving
isolation
studying
chronic
management,
cartilage
regeneration
neurodegenerative
disease.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
Abstract
Chronic
pancreatitis
(CP)
is
a
long‐standing
progressive
fibrosis
and
has
long
been
considered
incurable,
which
remains
heavy
health
burden
worldwide.
Mesenchymal
stem
cells
(MSCs)
with
anti‐fibrosis
properties
are
currently
used
in
the
treatment
of
fibroinflammatory
diseases.
However,
its
therapeutic
effect
limited
mainly
due
to
two
main
types
pathological
barriers
CP:
1)
Fibrotic
collagen
hinders
cell
delivery,
2)
Malignant
microenvironment
attacks
inactivation.
Here,
MSCs‐based
exogenous
nitric
oxide
(NO)
delivery
system
(MSCs‐Lip@RNO)
constructed.
In
MSCs‐Lip@RNO,
NO
not
only
can
be
booster
regulate
fibers,
relieve
vascular
compression
enhance
accumulation
MSCs
whole
pancreas,
but
also
form
protective
gas
layer
on
surface,
enhances
MSCs.
CP
rat
model,
pancreatic
injury
reduced
7
days
after
single
dose
administration
this
long‐acting
Collectively,
study
offers
promising
strategy
for
enhancing
efficacy
break
treatment.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Patients
and
healthcare
systems
face
significant
social
financial
challenges
due
to
the
increasing
number
of
individuals
with
chronic
external
internal
wounds
that
fail
heal.
The
complexity
healing
process
remains
a
serious
health
concern,
despite
effectiveness
conventional
wound
dressings
in
promoting
healing.
Recent
advancements
materials
science
fabrication
techniques
have
led
development
innovative
enhance
To
further
expedite
process,
novel
approaches
such
as
nanoparticles,
3D-printed
dressings,
biomolecule-infused
emerged,
along
cell-based
methods.
Additionally,
gene
therapy
technologies
are
being
harnessed
generate
stem
cell
derivatives
more
functional,
selective,
responsive
than
their
natural
counterparts.
This
review
highlights
potential
biomaterials,
3D
bioprinting,
gene-
therapies
However,
it
also
underscores
necessity
for
research
address
existing
integrate
these
strategies
into
standard
clinical
practice.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Abstract
In
the
progress
of
pulmonary
fibrosis
(PF),
normal
vascular
niche
plays
a
crucial
role
in
alveolar
regeneration
by
secreting
angiocrine
factors.
However,
malignant
interaction
between
myofibroblasts
and
endothelial
cells
results
significant
loss
capillaries
fibroblast
foci,
which
promotes
continuous
deterioration
fibrosis.
Herein,
an
engineered
mesenchymal
stem
cell
(MSC)
therapeutic
named
MSC‐MM@LPHN
is
developed
for
reconstructing
niche,
formed
modifying
surface
MSC
with
ROS‐responsive
lipid
polymeric
hybrid
nanoparticles
encapsulating
metformin
macitentan.
Due
to
homing
ability
MSC,
can
effectively
target
lung
tissue,
then
induce
myofibroblast
dedifferentiation
reduce
secretion
cytokines
that
cause
damage
preventing
from
turning
into
fibrotic
phenotype,
leading
recovery
function.
Combined
MSC‐secreted
growth
factors
promoting
angiogenesis,
ultimately
constructs
structure
area
reverses
bleomycin‐induced
PF.
The
findings
suggest
targeting
network
treat
PF,
provides
novel
strategy
fibrosis‐related
diseases.
BioMedical Engineering OnLine,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: March 21, 2025
Tissue
engineering
based
on
stem
cell
therapy
necessitates
a
substantial
quantity
of
high-quality
cells.
However,
current
sources
face
limitations,
including
narrow
donor
pools,
compromised
biological
properties
due
to
cryopreservation,
and
cellular
senescence
resulting
from
in
vitro
passaging
expansion.
This
study
examines
the
impact
mild
periodontitis
performance
dental
pulp
cells
(DPSCs)
explore
potential
broadening
pool
for
these
The
experiment
included
two
variables:
age
presence
periodontitis.
DPSCs
were
isolated
six
healthy
subjects
patients
with
Healthy
categorized
into
Groups
A
(28–32
years)
B
(52–54
years),
C
(31–33
D
(50–53
years).
analyses
morphology,
proliferation
rate,
multilineage
differentiation
capacity,
apoptosis,
surface
marker
expression.
No
significant
differences
pluripotency,
or
observed
between
controls
across
groups.
Additionally,
data
proliferation,
not
significantly
different.
In
subjects,
increased
was
correlated
more
elongated,
flattened,
broader
cells,
alongside
greater
heterogeneity
intercellular
granules.
capacities
decreased,
whereas
degree
apoptosis
increased.
Similar
trends
noted
remain
unchanged
teeth
periodontitis,
providing
valuable
insights
addressing
shortage
tissue
engineering.
Teeth
have
be
donors.
