Drug Delivery,
Journal Year:
2024,
Volume and Issue:
31(1)
Published: Oct. 15, 2024
The
gastrointestinal
tract
(GIT)
is
an
important
and
complex
system
by
which
humans
to
digest
food
absorb
nutrients.
GIT
vulnerable
diseases,
may
led
discomfort
or
even
death
in
humans.
Therapeutics
for
disease
treatment
face
multiple
biological
barriers,
significantly
decrease
the
efficacy
of
therapeutics.
Recognizing
barriers
pathophysiological
characteristics
be
helpful
design
innovative
Nanotherapeutics,
have
special
targeting
controlled
therapeutic
release
profiles,
been
widely
used
diseases.
Herein,
we
provide
a
comprehensive
review
barrier
GIT,
aid
promising
nanotherapeutics
treatment.
Furthermore,
several
typical
diseases
upper
lower
digestive
tracts,
such
as
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(5), P. 587 - 587
Published: April 30, 2025
Nanotechnologically
engineered
protein-based
carriers
have
attracted
considerable
attention
in
the
pharmaceutical
field
due
to
advantages
of
superior
biocompatibility,
tunability
and
good
emulsifying
properties.
Recently,
Pickering
emulsions
(PPEs)
systems
with
multi-level
structures
been
introduced
as
innovative
colloidal
delivery
for
advanced
drug
encapsulation,
protection,
controlled
release.
Natural
source
protein
nanoparticles
are
promising
candidates
provide
a
wide
range
functional
performances
interfacial
properties
preparation
stabilization
emulsions.
Herein,
this
review
summarizes
development
PPEs
systems,
focusing
on
research
progress
concerning
aspects
particle
methods,
formation
mechanisms
rational
design
principles,
emphasizing
relationship
between
structure
To
further
understand
behavior
nanoparticle
stabilized
emulsion,
mesoscopic
dissipative
dynamics
(DPD)
simulations
were
discussed,
which
bridges
gaps
macroscopic
time
length
scales,
well
molecular-scale
particles
oil/water
interface
systems.
The
structure-effect
tunable
physicochemical
design,
leads
effective
loading,
stimuli-responsiveness
release
multiple
delivery,
was
then
summarized.
Finally,
opportunities
challenges
future
discussed.
This
aims
reference
application
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 22, 2024
Abstract
Nanotechnology
has
significantly
facilitated
the
diagnosis
and
therapy
of
inflammatory
bowel
disease
(IBD).
To
obtain
better
therapeutic
efficacy,
a
nanoplatform
built
from
polysaccharides
metal‐phenolic
networks
(MPN)
is
developed
here
to
enhance
retention
in
damaged
intestinal
region
modulate
systemic
immunological
status
IBD
models.
Polysaccharides
tragacanth
gum
(GUM)
are
coordinated
with
iron
further
interact
shikonin
(Shik)
nanocomposite
named
Shik‐Fe@GUM.
Shik‐Fe@GUM
demonstrates
strong
persistent
accumulation
inflamed
region,
which
validated
clinical
specimens
patients,
cocultured
cellular
models,
living
animals.
served
as
scavenger
for
reactive
oxygen
or
nitrogen
species
tissues
cells,
alleviated
local
by
cytokine
downregulation.
In
addition,
restored
functions
colonic
barriers
mitigate
activity
index.
The
working
mechanisms
also
explored
genetic
sequencing
results
revealed
that
imposed
its
treatment
effect
attenuating
major
pathways.
particular,
can
IL‐17RA
relevant
cell
signaling
reduce
recruitment
T
h
17
cells
(T
helper
17).
This
polysaccharide‐metal‐functional
molecule
hybrid
strategy
be
broadly
applicable
other
drugs
their
index
patients.
Drug Delivery,
Journal Year:
2024,
Volume and Issue:
31(1)
Published: Oct. 15, 2024
The
gastrointestinal
tract
(GIT)
is
an
important
and
complex
system
by
which
humans
to
digest
food
absorb
nutrients.
GIT
vulnerable
diseases,
may
led
discomfort
or
even
death
in
humans.
Therapeutics
for
disease
treatment
face
multiple
biological
barriers,
significantly
decrease
the
efficacy
of
therapeutics.
Recognizing
barriers
pathophysiological
characteristics
be
helpful
design
innovative
Nanotherapeutics,
have
special
targeting
controlled
therapeutic
release
profiles,
been
widely
used
diseases.
Herein,
we
provide
a
comprehensive
review
barrier
GIT,
aid
promising
nanotherapeutics
treatment.
Furthermore,
several
typical
diseases
upper
lower
digestive
tracts,
such
as
