Engineered Carrier-Free Nanosystem-Induced In Situ Therapeutic Vaccines for Potent Cancer Immunotherapy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(36), P. 47270 - 47283

Published: Aug. 27, 2024

In situ vaccines that can stimulate tumor immune response have emerged as a breakthrough in antitumor therapy. However, the immunosuppressed microenvironment and insufficient infiltration of cells lead to ineffective immunity. Hence, biomimetic carrier-free nanosystem (BCC) induce synergistic phototherapy/chemotherapy-driven was designed. A developed using phototherapeutic reagents CyI celastrol raw materials. vitro vivo studies shown under NIR light irradiation, BCC-mediated photo/chemotherapy not only accelerates release drugs deeper parts tumors, achieving timing light-controlled drug delivery result cell apoptosis, but also effectively stimulates vaccine, which could invoke long-lasting immunity inhibit metastasis eliminate distant tumor. This therapeutic strategy holds promise for priming robust innate adaptive responses, arresting cancer progression, inducing dormancy.

Language: Английский

Self-catalyzed nitric oxide nanocomplexes induce ferroptosis for cancer immunotherapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 524 - 539

Published: Nov. 28, 2024

Language: Английский

“Convex Lens” of DNA damage: A nanomedicine enhances anti-PD-1 immunotherapy as immunogenic cell death inducer for “cold” melanoma

Nano Today, Journal Year: 2024, Volume and Issue: 61, P. 102598 - 102598

Published: Dec. 31, 2024

Language: Английский