Energy Loss and Range Calculations for Alpha Particles in B-100 Bone and C-552 Air-Equivalent Plastic Materials DOI Creative Commons
Metin Usta

Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi, Journal Year: 2024, Volume and Issue: 19(2), P. 175 - 183

Published: Nov. 7, 2024

The type of radiation that harms humans and living organisms is the ionizing type. In this radiation, passing through cell transfers energy to biological tissues causes harmful effects along with chemical changes. Therefore, exposure doses should be kept as low possible appropriate shielding materials used between tissue. study, stopping power range calculations B-100 bone C-552 air-equivalent plastic materials, which are International Commission on Radiation Units & Measurement (ICRU) were performed for alpha particles in 0.1 MeV - 10 MeV. effective charge approach within scope Bethe-Bloch theory Bohr stripping criterion was collision calculations. Continuous Slowing-Down Approximation (CSDA) method 3/8 Simpson approximation chosen error rates found less than 10% when results compared available literature data.

Language: Английский

Nanotechnology meets radiobiology: Fullerenols and Metallofullerenols as nano-shields in radiotherapy DOI Open Access
Paulina Kaźmierska, Maciej M. Jankowski, Elena Obrador

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117915 - 117915

Published: Feb. 20, 2025

Language: Английский

Citations

0
Excipients for Cerium Dioxide Nanoparticle Stabilization in the Perspective of Biomedical Applications DOI Creative Commons

Svetlana A. Titova,

Maria Petrovna Kruglova, Stupin Va

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1210 - 1210

Published: March 8, 2025

Rare earth metal nanoparticles, some of which are already widely used in medicine, growing interest the modern scientific community. One promising rare metals for biomedical applications is cerium, specifically its oxide form, characterized by a higher level stability and safety. According to number studies, cerium dioxide has wide range biological effects (regenerative, antimicrobial, antioxidant, antitumor), justifies potential application medicine. However, these their intensity vary significantly across studies. Since was it can be assumed that not only chemical formula important, but also physicochemical parameters nanoparticles obtained, consequently methods synthesis modification with use excipients. In this review, we considered possibilities using excipients (polyacrylate, polyvinylpyrrolidone, dextran, hyaluronic acid, chitosan, polycarboxylic acids, lecithin, phosphatidylcholine) context preserving properties, as well degree study combinations from point view prospect creating drugs based on applications.

Language: Английский

Citations

0
Progress and Application of Multifunctional Hydrogel in Radioactive Skin Injury DOI Creative Commons
Xinyue Cui, Jingyi Wang, Xinyi Xu

et al.

Advanced Materials Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

Abstract Radiation combined wound injury (RCWI) presents significant healing challenges due to radiation‐induced immune suppression, organ dysfunction, and disruption of growth factors extracellular matrix dynamics. Conventional dressings like gauze are inadequate for these complex injuries. Hydrogels have emerged as a promising solution skin mucosal injuries, offering superior mechanical strength, cell‐regeneration support, multifunctional biochemical properties, including antimicrobial, antioxidant, adhesive capabilities. They create moist, biocompatible environment that promotes cell proliferation, migration, tissue repair, while enabling sustained drug delivery, free radical scavenging, inflammation Deoxyribonucleic acid (DNA） repair. Despite their potential, systematic comparison radiation injuries remains lacking. This review addresses this gap by focusing on hydrogels supportive matrices therapeutic enhancers, exploring radiation‐impaired mechanisms, highlighting hydrogel advancements, comparing efficacy in common versus wounds. It also provides future research directions clinical practice insights, emphasizing the potential RCWI treatment. By bridging current knowledge gaps, aims guide improve practices radiology trauma medicine.

Language: Английский

Citations

0
Ruthenium Nanozyme@Magnesium silicate nanosheets encapsuled in microneedle patches promote repair of radiation‐induced skin defects by remodeling pathological environment DOI Creative Commons

Zhongyi Sun,

Haibo Liu, Lanying Li

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract Radiotherapy induced skin defect (RISD) is a severe radiotherapy complication with persistent oxidative stress and recurrent excessive reactive oxygen species (ROS), impeding normal tissue repair processes. Nevertheless, the lack of standardized animal model severely hinders progress related research work. We develop novel strategy for repairing RISD microenvironment, which combines initial ROS clearance, subsequent inhibition production proliferation cell pathways/functions. As proof concept, composite microneedle (MN) patch comprising γ‐polyglutamic acid as base ruthenium (Ru) clusters modified magnesium silicate nanosheets (MSR NSs) enzyme‐like component prepared. The Ru have excellent scavenging ability help activate peroxisome proliferators activated receptor signaling pathway confirmed by sequencing analysis while degraded under physiological conditions to release ions ions, enhancing proliferation, migration, angiogenesis ability. radiation established evaluate efficacy our MSR@MN in comparison γPGA‐MSR ointment commercial product Orgotein. results show that effectively improves pathological microenvironment abnormal accumulation, reduces inflammatory response promotes mature remodeling.

Language: Английский

Citations

0
Engineering Escherichia coli Nissle 1917 Carrying PD1 Agonists Resolves Intestinal Inflammation via Local Immune Modulation DOI
Meng‐Yuan Hu, Tingting Li, Mengmeng Xu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Immunological imbalance is a key factor in the progression of intestinal inflammation, yet effective treatments remain elusive. Using radiation-induced injury model, we investigated causes inflammation at single-cell level and identified abnormal T-cell activation as major contributor. To address this, targeted PD1 signaling pathway to suppress evaluated anti-inflammatory repair effects agonist displaying probiotic Escherichia coli Nissle 1917 (EcNMP1-M) two mouse models. Encapsulated Eudragit L100-55 for pH-dependent release, EcNMP1-M its bacterial outer membrane vesicles (OMVs) expressed agonists, which inhibited excessive immune reduced inflammatory cytokines. promoted expression proteins that maintain epithelial barrier integrity, improving gut function responses colitis mice. Furthermore, 16S rDNA microbiome sequencing revealed enhanced microbiota diversity, increased beneficial bacteria, harmful bacteria. This study proposes localized EcN-based immunosuppressive therapy enteritis bowel disease with promising potential clinical applications.

Language: Английский

Citations

0
Radiation-thermal modification of fluoroplastic composite and evaluation of its radiation-protective characteristics DOI
В. И. Павленко, V. V. Kashibadze,

А. В. Носков

et al.

Materials Chemistry and Physics, Journal Year: 2024, Volume and Issue: unknown, P. 130162 - 130162

Published: Nov. 1, 2024

Language: Английский

Citations

1
Self-Assembled EGCG Nanoparticles with Enhanced Intracellular ROS Scavenging for Skin Radioprotection DOI Creative Commons
Xianlin Han,

R.F. Xu,

Xia Yang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13135 - 13148

Published: Dec. 1, 2024

Skin radiation damage is a prevalent form of tissue injury encountered during radiotherapy, accidents, and occupational exposure. The only clinically approved radioprotective agent, amifostine, associated with numerous side effects, underscoring the urgent need for development safe effective agents. Natural products reductive properties possess high antioxidant activity biocompatibility, but their low bioavailability limits efficacy clinical application. To address this, we utilized epigallocatechin gallate (EGCG) as model compound employed nanotechnology to enhance cellular uptake natural compounds, thereby improving free radical scavenging capabilities.

Language: Английский

Citations

1
Energy Loss and Range Calculations for Alpha Particles in B-100 Bone and C-552 Air-Equivalent Plastic Materials DOI Creative Commons
Metin Usta

Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi, Journal Year: 2024, Volume and Issue: 19(2), P. 175 - 183

Published: Nov. 7, 2024

The type of radiation that harms humans and living organisms is the ionizing type. In this radiation, passing through cell transfers energy to biological tissues causes harmful effects along with chemical changes. Therefore, exposure doses should be kept as low possible appropriate shielding materials used between tissue. study, stopping power range calculations B-100 bone C-552 air-equivalent plastic materials, which are International Commission on Radiation Units & Measurement (ICRU) were performed for alpha particles in 0.1 MeV - 10 MeV. effective charge approach within scope Bethe-Bloch theory Bohr stripping criterion was collision calculations. Continuous Slowing-Down Approximation (CSDA) method 3/8 Simpson approximation chosen error rates found less than 10% when results compared available literature data.

Language: Английский

Citations

0