Oral microbiota in colorectal cancer: Unraveling mechanisms and application potential

Life Sciences, Journal Year: 2025, Volume and Issue: 365, P. 123462 - 123462

Published: Feb. 11, 2025

Language: Английский

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Novel Therapeutic Strategies and Recent Advances in Gut Microbiota Synergy with Nanotechnology for Colorectal Cancer Treatment

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101601 - 101601

Published: Feb. 20, 2025

Over the last two decades, molecular biology advances have revealed gut microbiota's active and crucial role in colorectal cancer (CRC) pathogenesis its dysregulation during tumorigenesis. This understanding has underscored urgency of exploring novel therapeutic approaches to address challenges posed by CRC. Among these approaches, nanosynergistic therapies, with their potential modulate microbiota, increase drug bioavailability stability, reduce side effects, emerged as a promising avenue. Furthermore, efficacy nanotechnology-based can be enhanced combining them different methods, including chemotherapy, radiotherapy, immunotherapy, photothermal therapy, sonodynamic therapy. Herein, recent progress nano synergistic therapy been reviewed, focusing on synergy between microbiota nanotechnology CRC treatment. Additionally, diverse applications nanoparticles analyzed provide innovative ideas effective solutions for developing highly treatment strategies.

Language: Английский

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Aspirin in Cancer Therapy: Pharmacology and Nanotechnology Advances

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2327 - 2365

Published: Feb. 1, 2025

Aspirin, a non-steroidal anti-inflammatory drug (NSAID), has garnered significant attention for its anti-cancer potential. This review explores the pharmacological properties, chemical dynamics, and evolving therapeutic applications of aspirin, with an emphasis on integration into advanced cancer therapies. Aspirin demonstrates broad-spectrum efficacy across diverse types by modulating signaling pathways such as COX-dependent COX-independent mechanisms, including Wnt, NF-κB, β-catenin/TCF, IL-6/STAT3. Recent advancements highlight role nanotechnology in enhancing aspirin's targeted delivery, effectiveness, patient outcomes. Nanoparticle-based formulations, liposomes, solid lipid nanoparticles, mesoporous silica offer improved solubility, stability, bioavailability, enabling controlled release tumor-specific targeting. These innovations reduce systemic toxicity enhance effects, paving way personalized treatments. Ongoing clinical studies reinforce safety profile, underscoring pharmacotherapy. calls continued research repurposing combination therapies novel delivery systems to maximize

Language: Английский

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The Role of Reactive Oxygen Species in Colorectal Cancer Initiation and Progression: Perspectives on Theranostic Approaches

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 752 - 752

Published: Feb. 22, 2025

Altered levels of reactive oxygen species (ROS) are recognized as one the key factors in mediating tumor cell survival tissue microenvironment, where they play a role initiation, progression and recurrence/relapse colorectal cancer (CRC). Tumor cells can adapt to oxidative stress (OS) using genetic or metabolic reprogramming long short term. In addition, defend themselves through positive regulation antioxidant molecules, enhancing ROS-driven proliferation. Balanced eustress influence chemotherapy resistance, allowing survive treatment. Secondary effects include increased ROS production redox stress, which kill eliminate drug resistance. Anticancer treatments based on manipulating could represent gold standard CRC therapy. Therefore, exploring modulation response OS deregulated signaling pathways may lead development new personalized overcome therapy this review, we explore initiation their diagnostic implications biomarkers disease. Furthermore, focused involvement different therapeutic options, such surgery, radiotherapy, theranostic imaging, immunotherapy other precision medicine approaches.

Language: Английский

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Interplay of gut microbiota in Kawasaki disease: role of gut microbiota and potential treatment strategies

Future Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: Feb. 27, 2025

Kawasaki disease (KD) is an acute systemic immune vasculitis with predominant involvement of the medium and small arteries. It mostly affects pediatric patients, representing most common form in children less than 5 years old. Numerous diseases, especially those related to system, have established links intestinal flora. Recent studies investigated flora changes throughout management KD. There was gut microbiota dysbiosis KD at phase, particularly downregulation short-chain fat acids-producing over-proliferation opportunistic pathogens. The relationship between response therapies individuals specific remains uncertain. Targeted microbial supplements dietary regulation may serve as potential measures alleviate complications thus improve prognosis. This review provides overview current understanding interplay Furthermore, it discusses possibility altering reinstate a healthy condition.

Language: Английский

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Plant polysaccharide‐capped nanoparticles: A sustainable approach to modulate gut microbiota and advance functional food applications

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2025, Volume and Issue: 24(2)

Published: March 1, 2025

Plant-derived polysaccharides have emerged as sustainable biopolymers for fabricating nanoparticles (polysaccharide-based nanomaterials [PS-NPs]), presenting unique opportunities to enhance food functionality and human health. PS-NPs exhibit exceptional biocompatibility, biodegradability, structural versatility, enabling their integration into functional foods positively influence gut microbiota. This review explores the mechanisms of interaction with microbiota, highlighting ability promote beneficial microbial populations, such Lactobacilli Bifidobacteria, stimulate production short-chain fatty acids. Key synthesis stabilization methods are discussed, focusing on role in improving bioavailability, stability, gastrointestinal delivery bioactive compounds systems. The potential address challenges science, including enhancing nutrient absorption, mitigating intestinal dysbiosis, supporting through innovative nanotechnology, is critically evaluated. Barriers enzymatic degradation physicochemical stability analyzed, alongside strategies optimize within complex matrices. systems offers a novel approach modulate improve health, drive development next-generation foods. Future research should focus bridging knowledge gaps metagenomic metabolomic profiling PS-NPs, optimizing design diverse applications, advancing health-promoting innovations.

Language: Английский

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Uncovering the Effects and Molecular Mechanisms of Shaoyao Decoction Against Colorectal Cancer Using Network Pharmacology Analysis Coupled With Experimental Validation and Gut Microbiota Analysis

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(6)

Published: March 1, 2025

ABSTRACT Background Chronic gut inflammation and dysbiosis contribute significantly to colorectal cancer (CRC) development. Shaoyao decoction (SYD) is a well‐established Chinese medicine prescription. Besides ameliorating CRC via anti‐inflammatory effects, SYD modulates microbiota (GM) improve inflammatory responses in ulcerative colitis (UC). However, whether how suppresses by regulating GM remains largely unknown. Methods SD rats were orally administered for 7 days obtain medicated serum. We utilized liquid chromatography–mass spectrometry (LC–MS) analysis, GeneCards, DisGeNET, SwissTargetPrediction databases analyze blank SYD‐medicated rat serum, comparing the findings with those of aqueous extract previous studies identify circulating compounds/components predictable target genes. Using network pharmacology, potential active compounds corresponding hub genes associated modulating suppress selected molecular docking. In vivo experiments, transplantation tumor model was established BALB/c mice using CT26 cells, gavage 14 days. To investigate mechanism SYD‐regulated against CRC, HE IHC staining, Western blotting, 16S rRNA sequencing employed. Results LC–MS identified 26 computationally predicted Network pharmacology prioritized 13 targeting 8 inflammation/immunity‐related (IL‐17/TNF pathways), validated dose‐dependently suppressed growth ( p < 0.05, medium/high doses), as confirmed staining analysis Ki‐67. Notably, potentially delayed liver metastasis alleviated hepatic injury tumor‐bearing mice. blotting demonstrated SYD's inhibition IL‐17/TNF/NF‐κB axis, aligning computational predictions. revealed SYD‐enriched Akkermansia structural shifts, mechanistically linking remodeling anti‐tumor efficacy. Conclusions combats dual modulation signaling ecosystems (e.g., enrichment). This microbiota‐immune crosstalk positions adjunct conventional therapies, particularly patients dysbiosis.

Language: Английский

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Redox-responsive chondroitin sulfate-based micelle system for enhanced chemotherapy and inflammation suppression to synergistically antitumor therapy

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143686 - 143686

Published: April 1, 2025

Language: Английский

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Mesoporous polydopamine (MPDA)-based drug delivery system for oral chemo-photothermal combinational therapy of orthotopic colon cancer

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136618 - 136618

Published: Oct. 16, 2024

Language: Английский

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Graphene/carbohydrate polymer composites as emerging hybrid materials in tumor therapy and diagnosis

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 287, P. 138621 - 138621

Published: Dec. 10, 2024

Language: Английский

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