Nanomaterials‐Induced Pyroptosis: Advancing Novel Therapeutic Pathways in Nanomedicine

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Pyroptosis, a form of programmed cell death characterized by lysis and inflammation, has significant implications for disease treatment. Nanomaterials (NMs), with their unique physicochemical properties, can precisely modulate pyroptosis, offering novel intelligent therapeutic strategies cancer, infectious diseases, chronic inflammatory conditions targeted activation reduced systemic toxicity. This review explores the mechanisms which NMs regulate comparing molecular NM inducers, examines role intrinsic properties such as size, shape, surface charge, chemical composition in these processes. It also discusses balance between beneficial adverse effects NM‐induced highlighting delivery systems, modifications, controlled to enhance efficacy intelligence while minimizing Notably, mRNA‐based nanomedicine be intelligently designed activate achieving desired outcomes tailored evolving microenvironment diseases. By understanding interactions, potential harnessed develop innovative treatments manage pyroptosis‐associated diseases safely, effectively, intelligently. highlights transformative clinical applications.

Language: Английский

A Pyroptosis Radiosensitizer Facilitates Hypoxic Tumor Necrosis

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Hypoxia-related tumor radioresistance markedly impairs the efficacy of radiotherapy. Herein, a targeted radiosensitization strategy is introduced, leveraging upregulation gasdermin C (GSDMC) in hypoxic cells, aiming to induce pyroptosis through application cobalt-containing polyoxometalate-based radiosensitizer. This novel radiosensitizer designed for precisely controlled release cobalt ions upon X-ray irradiation, thereby activating caspase-8 and prompting cleavage GSDMC. sequence events selectively triggers directly addressing radioresistance. The ensuing results highlight enhanced radiotherapy necrosis both vitro vivo models. Overall, findings confirm effectiveness this targeting high GSDMC expression tumors precise Such encourage further exploration hypoxia-driven improve cancer treatment outcomes.

Language: Английский

Metabolism-Related Programmed Cell Death: Unveiling Prognostic Biomarkers, Immune Checkpoints, and Therapeutic Strategies in Ovarian Cancer

Cancer Investigation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: April 7, 2025

Ovarian cancer (OC), the gynecologic malignancy with poorest prognosis, is driven by metabolic reprogramming and dysregulated programmed cell death (PCD). However, their interplay prognostic significance remain inadequately understood. Transcriptomic data from OC patients healthy controls (TCGA GTEx) were analyzed to identify differentially expressed genes (DEGs) intersecting metabolism-related (MRGs) PCD-related (PCDRGs). Prognostic determined using univariate Cox regression, LASSO, multivariate stepwise analyses. Consensus clustering revealed enrichment differences, while a risk model nomogram developed for outcome prediction. Associations between genes, immune microenvironment, drug sensitivity also assessed. A total of 166 candidate identified, PLA2G2D, LPCAT3, ARG1, PLA2G4A, EXOSC3 emerging as significant markers. The demonstrated marked survival showed robust calibration Differential infiltration was observed groups. Additionally, Sinularin Fulvestrant exhibited variable sensitivity, validated through molecular docking models. Metabolism-related PCD identified pivotal markers in OC, providing critical insights evaluation targeted therapy development.

Language: Английский