ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
17(1), P. 157 - 173
Published: Dec. 18, 2024
Autism
spectrum
disorder
(ASD)
is
characterized
by
cognitive
inflexibility
and
social
deficits,
with
a
notably
limited
range
of
brain-targeted
medications,
particularly
in
the
field
nanomedicine.
Herein,
we
introduce
H2S
donor
cross-linked
nanomicelle,
named
mannose-PEG600-lipoic
acid
(Man-LA).
Man-LA
demonstrates
enhanced
stability
precise
brain
delivery
interacting
glucose
transporter
1
(GLUT1)
astrocytes,
facilitating
gradual
release
that
modulated
glutathione
(GSH).
In
vivo,
studies
suggest
alleviates
symptoms
ASD,
correlating
increased
expression
aerobic
glycolysis
enzymes,
elevated
lactate
production,
higher
levels,
while
preventing
damage
to
hippocampal
neurons.
vitro,
tightly
binds
aldehyde
dehydrogenase
family
3
member
B1
(Aldh3b1)
upregulating
its
expression.
This
interaction
promotes
enhances
production.
These
findings
connection
between
ASD
deficits
dysregulation
astrocytic
glycolysis,
underscoring
role
H2S.
Identifying
Aldh3b1
gene
within
pathways
provides
promising
target
for
treatment.
Cancer Nanotechnology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 17, 2025
Emphasizing
the
significance
of
cancer-associated
fibroblasts
(CAFs),
non-malignant
yet
pivotal
players
within
tumor
microenvironment
(TME),
this
review
illuminates
role
inflammatory
subtype
(iCAF)
as
catalysts
in
cancer
proliferation,
metastasis,
and
therapeutic
resistance.
Given
their
paramount
importance,
targeting
CAFs
emerges
a
robust
strategy
evolving
landscape
immunotherapy.
Nanomaterials,
distinguished
by
unique
features
malleability,
hold
considerable
promise
biomedicine,
especially
precision-oriented
domain
therapy.
Their
aptitude
for
modulating
immune
responses,
amplifying
drug
efficacy
through
precise
delivery,
discerningly
focusing
on
cells
TME
situates
nanomaterials
formidable
tools
to
transcend
boundaries
set
conventional
treatments.
This
scrutinizes
convoluted
interplay
among
CAFs,
cells,
TME.
It
further
showcases
widely
utilized
management.
We
underscore
potential
nanoscale
delivery
systems
directed
at
underscoring
transformative
power
revolutionizing
therapies,
enhancing
precision,
culminating
improved
patient
outcomes.
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
In
this
study,
a
novel
ASGP-R
targeted
contrast
agent
has
been
developed
for
liver
cancer
diagnosis,
which
exhibits
high
imaging
efficacy
and
great
biosafety,
holding
promise
as
MRI
of
human
cancer.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1648 - 1648
Published: Feb. 14, 2025
Colorectal
cancer
(CRC)
is
a
leading
cause
of
cancer-related
deaths
worldwide,
characterized
by
high
incidence
and
poor
survival
rates.
Glycosylation,
fundamental
post-translational
modification,
influences
protein
stability,
signaling,
tumor
progression,
with
aberrations
implicated
in
immune
evasion
metastasis.
This
study
investigates
the
role
glycosylation-related
genes
(Glycosylation-RGs)
CRC
using
machine
learning
bioinformatics.
Data
from
The
Cancer
Genome
Atlas
(TCGA)
Molecular
Signatures
Database
(MSigDB)
were
analyzed
to
identify
67
differentially
expressed
Glycosylation-RGs.
These
used
classify
patients
into
two
subgroups
distinct
outcomes,
highlighting
their
prognostic
value.
Weighted
gene
coexpression
network
analysis
(WGCNA)
revealed
key
modules
associated
traits,
including
pathways
like
glycan
biosynthesis
PI3K-Akt
signaling.
A
machine-learning-based
model
demonstrated
strong
predictive
performance,
stratifying
high-
low-risk
groups
significant
differences.
Additionally,
correlations
between
risk
scores
cell
infiltration,
providing
insights
microenvironment.
Drug
sensitivity
identified
potential
therapeutic
agents,
Trametinib,
SCH772984,
Oxaliplatin,
showing
differential
efficacy
groups.
findings
enhance
our
understanding
glycosylation
CRC,
identifying
it
as
critical
factor
disease
progression
promising
target
for
future
strategies.
