Journal of Chromatography A, Journal Year: 2024, Volume and Issue: 1739, P. 465542 - 465542
Published: Nov. 20, 2024
Language: Английский
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113559 - 113559
Published: Feb. 27, 2025
Language: Английский
Citations
1
Small, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Abstract Fluorescent nanoparticles such as quantum dots, carbon and polymeric fluorophore conjugates have shown promising applications for biomedical imaging. It is desirable to develop new fluorescent probes with well‐defined particle size, bright fluorescence, high biocompatibility, easy functionalization. Here, a facile controllable method first reported prepare size‐tunable unimolecular (FUNs) The FUNs are constructed by the rapid ring‐opening polymerization (ROP) of amino acid N ‐carboxyanhydrides monomers using dye‐cored polylysine dendritic macromolecule macroinitiator. By precisely adjusting ratio monomer macroinitiator, study customizes sizes 30, 60, 90, or 130 nm. fluorescence yield up 6.6‐fold small molecule dye. that size‐dependent cellular uptake, blood circulation, tumor entrance optical imaging glutamic acids (Glu)‐modified (FUNs‐Glu). FUNs‐Glu 30 60 nm exhibited superior accumulation, penetration. These dots merits tunable single‐molecule structure, excellent properties, ample groups surface functionalization, which great potential various
Language: Английский
Citations
0
Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(5), P. 166 - 166
Published: May 8, 2025
The rapid development of microfluidics has driven innovations in material engineering, particularly through its ability to precisely manipulate fluids and cells at microscopic scales. Microfluidic biomaterials, a cutting-edge interdisciplinary field integrating microfluidic technology with biomaterials science, are revolutionizing biomedical research. This review focuses on the functional design fabrication organ-on-a-chip (OoAC) platforms via 3D bioprinting, explores applications drug delivery, cell culture, tissue evaluates potential systems advancing personalized healthcare. We systematically analyze evolution materials—from silicon glass polymers paper—and highlight advantages bioprinting over traditional methods. Currently, despite significant advances medicine, challenges scalability, stability, clinical translation remain. future will depend combining dynamic design, developing hybrid strategies that combine molds bio-printed structures, using artificial intelligence monitor delivery or response real time. believe collaborations between materials micromachining, medicine accelerate into therapies high-throughput screening tools.
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 10, 2024
Lipid nanoparticles (LNPs) have emerged as the leading nonviral nucleic acid (NA) delivery system, gaining widespread attention for their use in COVID-19 vaccines. They are recognized efficient NA encapsulation, modifiability, and scalable production. However, LNPs face efficacy potency limitations due to suboptimal intracellular processing, with endosomal escape efficiencies (ESE) below 2.5%. Additionally, up 70% of NPs undergo recycling exocytosis after cellular uptake. In contrast, cell-derived vesicles offer biocompatibility high-delivery but challenging load exogenous NAs manufacture at large-scale. To leverage strengths both systems, a hybrid system is designed by combining vesicles, such nano plasma membrane (nPMVs), through microfluidic mixing subsequent dialysis. These hybrids demonstrate tenfold increase ESE an 18-fold rise reporter gene expression vitro vivo zebrafish larvae (ZFL) mice, compared traditional LNPs. improvements linked unique physico-chemical properties, composition, morphology. By incorporating this strategy streamlines development process, significantly enhancing systems without need extensive screening.
Language: Английский
Citations
3
Journal of Chromatography A, Journal Year: 2024, Volume and Issue: 1739, P. 465542 - 465542
Published: Nov. 20, 2024
Language: Английский
Citations
1