Placenta and Reproductive Medicine,
Journal Year:
2024,
Volume and Issue:
3
Published: Aug. 6, 2024
Objectives:
The
objective
of
this
review
was
to
summarize
currently
developed
advanced
drug
delivery
systems
that
can
be
used
for
pregnancy
related
disorders
along
with
their
advantages
and
clinical
relevance.
Methods:
This
process
a
defined
search
strategy
indexed
publications
from
databases
like
Google
scholar,
PubMed,
Embase,
Medline,
Scopus
UTMB
library
2000
2020
included
methods
assess
the
quality
evidence
retrieved.
Results:
Pregnancy
is
unique
physiological
condition
where
some
drugs
will
lifesaving
mother,
but
they
toxic
fetal
tissue.
It
mandatory
research
on
novel
systems.
Although
there
substantial
quantity
has
been
carried
out
maternal
-placental-fetal
uptake,
transfer,
toxicity,
therapeutic
evaluations
in
remain
infancy.
Conclusions:
In
review,
we
highlighted
considerations
placenta
summarized
recent
work
as
well
potential
applications
reality.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 14, 2025
It
is
well
established
that
the
physicochemical
properties
of
lipid
nanoparticles
(LNPs)
can
govern
their
interactions
with
various
biological
barriers.
One
property
hypothesized
to
influence
nanoparticle-cell
elasticity.
Here,
we
formulate
LNPs
naturally
occurring
cholesterol
analogs
tune
LNP
elasticity
and
study
its
role
on
mRNA
delivery
placenta.
was
measured
via
atomic
force
microscopy
where
these
exhibited
Young's
moduli
ranging
from
71.0
±
26.2
411.4
145.7
kPa.
In
vitro
screening
in
placental
trophoblasts
showed
stiffer
improved
uptake
compared
softer
LNPs.
Following
intravenous
administration
pregnant
mice,
incorporating
β-sitosterol
enhanced
reduced
liver
containing
only
cholesterol.
These
results
demonstrate
ability
promote
highlight
potential
tuning
improve
LNP-mediated
organs
interest.
Analytica Chimica Acta,
Journal Year:
2025,
Volume and Issue:
unknown, P. 343944 - 343944
Published: March 1, 2025
Lipid
nanoparticles
(LNPs)
have
become
an
important
delivery
system
for
nucleic
acids,
as
applied
in
the
first
RNAi
drug
and
two
COVID-19
mRNA
vaccines
approved
by
FDA.
Despite
advantages
of
their
high
cargo
capacity,
low
immunogenicity
allowing
redosing,
scalability
low-cost
manufacturing,
challenges
such
liver
accumulation
difficulties
quality
control
persist
LNPs
development.
Conjugation
antibodies
or
antibody
fragments
onto
holds
promise
achieving
precise
targeting
higher
stability
moieties
on
LNP
surfaces.
However,
multiple-component
products
poses
additional
compared
to
alone.
size
mass
are
critical
attributes
which
play
roles
determining
LNPs'
acid
loading,
conjugation
level,
biodistribution,
capability,
overall
efficacy.
Macro
photometry
(MMP),
a
single-molecule
technique,
enabled
orthogonal
characterization
incorporating
contrast
analysis
proxy
particle
combining
it
with
measurement.
This
approach
thus
improves
definition
species
within
heterogeneous
systems.
Using
MMP,
this
study
revealed
effects
PEG-lipid
concentration,
encapsulation,
mass.
Additionally,
demonstrated
MMP's
utility
monitoring
under
various
stress
conditions,
including
pH,
oxidation,
freeze-thaw
cycles,
agitation.
represents
use
analysis,
simultaneously
characterizing
LNPs.
It
highlights
potential
MMP
valuable
tool
supports
formulation
Chemical Research in Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Nanoparticles,
defined
by
their
nanoscale
dimensions
and
unique
physicochemical
properties,
are
widely
utilized
in
healthcare,
electronics,
environmental
sciences,
consumer
products.
However,
increasing
evidence
of
potential
embryotoxic
effects
during
pregnancy
underscores
the
need
for
a
molecular-level
understanding
interactions
embryonic
development.
Nanoparticles
such
as
titanium
dioxide,
silver,
cerium
oxide,
copper
quantum
dots
can
cross
placental
barrier
interfere
with
crucial
developmental
processes.
At
molecular
level,
they
disrupt
signaling
pathways
like
Wnt
Hedgehog,
induce
oxidative
stress
inflammation,
cause
genotoxic
effects,
all
critical
sensitive
phases,
organogenesis.
Furthermore,
these
nanoparticles
interact
directly
cellular
components,
including
DNA,
proteins,
lipids,
impairing
function
viability.
Innovative
strategies
to
mitigate
nanoparticle
toxicity,
surface
modifications
incorporation
biocompatible
coatings,
discussed
solutions
reduce
adverse
interactions.
Various
laboratory
animal
models
used
investigate
nanoparticle-induced
embryotoxicity
evaluated
efficacy
limitations,
providing
insights
into
applicability
effects.
This
Account
examines
mechanisms
which
compromise
development
emphasizes
importance
designing
safer
minimize
maternal-fetal
exposure
risks,
particularly
biomedical
applications.
Placenta and Reproductive Medicine,
Journal Year:
2024,
Volume and Issue:
3
Published: Aug. 6, 2024
Objectives:
The
objective
of
this
review
was
to
summarize
currently
developed
advanced
drug
delivery
systems
that
can
be
used
for
pregnancy
related
disorders
along
with
their
advantages
and
clinical
relevance.
Methods:
This
process
a
defined
search
strategy
indexed
publications
from
databases
like
Google
scholar,
PubMed,
Embase,
Medline,
Scopus
UTMB
library
2000
2020
included
methods
assess
the
quality
evidence
retrieved.
Results:
Pregnancy
is
unique
physiological
condition
where
some
drugs
will
lifesaving
mother,
but
they
toxic
fetal
tissue.
It
mandatory
research
on
novel
systems.
Although
there
substantial
quantity
has
been
carried
out
maternal
-placental-fetal
uptake,
transfer,
toxicity,
therapeutic
evaluations
in
remain
infancy.
Conclusions:
In
review,
we
highlighted
considerations
placenta
summarized
recent
work
as
well
potential
applications
reality.
