Prodrug Self‐Assemblies Based on Plant Volatile Aldehydes with Improved Stability and Antimicrobial Activity Against Plant Pathogens DOI Open Access

Gaohua Hu,

Zhiyuan Zhou, Gang Tang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Plant volatile aldehydes (PVAs) such as cinnamaldehyde (Cin), citral (Cit), citronellal (Citr), and perillaldehyde (Per) have broad-spectrum antimicrobial activity show great potential in agricultural sustainable production. However, most PVAs not only very high volatility but also are easily degradable environment, which seriously restricts their wide application. To address the inherent problems with PVAs, four prodrugs based on fabricated by conjugating individually Cin, Cit, Citr, Per to sodium bisulfite (Sod) through a simple addition reaction subsequently self-assembled into nanoparticles (prodrug self-assemblies) aqueous solutions. The results showed that pH of 7 temperature 35 °C optimal conditions for formation prodrug self-assemblies highest self-assembly rates. prepared spherical average particle sizes 100-200 nm, almost no volatilization, surface stability, can respond acidic redox microenvironments release PVAs. synergistic activities against Sclerotinia sclerotiorum Penicillium digitatum, good biological safety plants. Therefore, these findings important implications efficient utilization agriculture, ensuring ecological environment realizing development agriculture.

Language: Английский

Recent advances in modifications, biotechnology, and biomedical applications of chitosan-based materials: A review DOI
Ying Yu,

Zhongwen Su,

Yonggang Peng

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138772 - 138772

Published: Dec. 1, 2024

Language: Английский

Citations

5
Dynamic Bonds in Biopolymers: Enhancing Performance and Properties DOI Open Access
Trong Danh Nguyen, Jun Seop Lee

Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 457 - 457

Published: Feb. 9, 2025

As the demand for polymer materials increases, conventional petroleum-based synthetic polymers face several significant challenges, including raw material depletion, environmental issues, and potential biotoxicity in biological applications. In response, bio-based derived from natural sources, such as cellulose, alginate, chitosan, gelatin, have garnered attention due to their advantages of biocompatibility biodegradability. However, these often suffer poor physical stability high density hydrogen bonds large structure pyranose rings. This review explores incorporating dynamic covalent into biopolymers overcome limitations. The chemical structures contain numerous functional groups that can serve anchoring sites bonds, thereby enhancing mechanical properties overall network. discusses performance improvements achievable through examines future this technology enhance expand applicability fields.

Language: Английский

Citations

0
A mussel-inspired wet-adhesive prolonged-acting antibacterial hydrogels for the treatment of periodontitis DOI

Menglin Fan,

Jiaojiao Yang, Zhen Li

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161262 - 161262

Published: March 1, 2025

Language: Английский

Citations

0
NIR-activating glycyrrhizic acid/carbon nanozyme injectable polysaccharides-based hydrogels for promoting polymicrobial infected wound healing DOI
Chenhao Zhang, Shu-Wen Sun, Tianyu Zhu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142082 - 142082

Published: March 1, 2025

Language: Английский

Citations

0
Natural-derived porous nanocarriers for the delivery of essential oils DOI
Hongxin Chen,

Xiaoyu Su,

Yunfeng Luo

et al.

Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(12), P. 1117 - 1133

Published: Dec. 1, 2024

Language: Английский

Citations

0
Prodrug Self‐Assemblies Based on Plant Volatile Aldehydes with Improved Stability and Antimicrobial Activity Against Plant Pathogens DOI Open Access

Gaohua Hu,

Zhiyuan Zhou, Gang Tang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Plant volatile aldehydes (PVAs) such as cinnamaldehyde (Cin), citral (Cit), citronellal (Citr), and perillaldehyde (Per) have broad-spectrum antimicrobial activity show great potential in agricultural sustainable production. However, most PVAs not only very high volatility but also are easily degradable environment, which seriously restricts their wide application. To address the inherent problems with PVAs, four prodrugs based on fabricated by conjugating individually Cin, Cit, Citr, Per to sodium bisulfite (Sod) through a simple addition reaction subsequently self-assembled into nanoparticles (prodrug self-assemblies) aqueous solutions. The results showed that pH of 7 temperature 35 °C optimal conditions for formation prodrug self-assemblies highest self-assembly rates. prepared spherical average particle sizes 100-200 nm, almost no volatilization, surface stability, can respond acidic redox microenvironments release PVAs. synergistic activities against Sclerotinia sclerotiorum Penicillium digitatum, good biological safety plants. Therefore, these findings important implications efficient utilization agriculture, ensuring ecological environment realizing development agriculture.

Language: Английский

Citations

0