In situ forming and self-crosslinkable protein hydrogels for localized cancer therapy and topical wound healing DOI

Soomin Eom,

Seong Guk Park,

Yong Hoe Koo

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 460 - 475

Published: Dec. 21, 2024

Language: Английский

Advances in the study of polysaccharide-based hydrogel wound dressings DOI
Yu Zhang, Ning Qiao, Lihua Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142134 - 142134

Published: March 1, 2025

Language: Английский

Citations

1
Novel Strategies in Breast Cancer Management: from Treatment to Long-term Remission DOI

S Habibi,

Shabbou Bahramian,

Saeedeh Zare Jalise

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104715 - 104715

Published: April 1, 2025

Language: Английский

Citations

1
Pluripotent polysaccharide coordinated hydrogels remodel inflammation, neovascularization and reepithelization for efficient diabetic wound prohealing DOI
Xueliang Zhang,

Fangrui Ning,

Yingying Li

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 37 - 53

Published: Nov. 17, 2024

Language: Английский

Citations

4
Applications of Hydrogels in Emergency Therapy DOI Creative Commons
Mariana Chelu, Mónica Popa,

José María Calderón Moreno

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 234 - 234

Published: March 23, 2025

Interest in developing new, effective materials for emergency hemostasis and wound healing is steadily increasing, particularly use emergency, surgical, military situations. Hydrogels, with their unique retention, swelling, biocompatibility properties, have emerged as essential therapy. This review provides a comprehensive examination of recent hydrogel applications acute medical scenarios, including hemostasis, management, drug delivery, soft tissue replacement, engineering. We discuss the physicochemical properties that make hydrogels suitable rapid response situations, such tunable mechanical strength, adhesiveness, responsiveness to environmental stimuli, ability encapsulate release therapeutic agents. Additionally, article explores advancements smart self-healing antimicrobial providing insights into potential revolutionize care increase survival rates both civilian applications. Through critical evaluation current clinical trials practical deployments, this highlights successes challenges faced integrating protocols, roadmap future research development dynamic field.

Language: Английский

Citations

0
Advanced Hydrogels in Breast Cancer Therapy DOI Creative Commons

Xiangyu Gao,

Benjamin R. Caruso,

Weimin Li

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 479 - 479

Published: July 19, 2024

Breast cancer is the most common malignancy among women and second leading cause of cancer-related death for women. Depending on tumor grade stage, breast primarily treated with surgery antineoplastic therapy. Direct or indirect side effects, emotional trauma, unpredictable outcomes accompany these traditional therapies, calling therapies that could improve overall treatment recovery experiences patients. Hydrogels, biomimetic materials 3D network structures, have shown great promise augmenting Hydrogel implants can be made adipogenic angiogenic properties tissue integration. organoids malignant tumors grown in hydrogels retain physical genetic characteristics native tumors, allowing post-surgery recapitulation diseased tissues precision medicine assessment responsiveness patient-specific cancers to treatment. Hydrogels also used as carrier matrices delivering chemotherapeutics immunotherapeutics prosthetic scaffolds. The hydrogel delivery systems achieve localized controlled medication release targeting site, enhancing efficacy minimizing adverse effects therapeutic agents delivered by procedures. This review aims summarize recent advancements utilization reconstruction, modeling, therapy discuss their limitations clinical translation.

Language: Английский

Citations

3
Triggering Pyroptosis by Doxorubicin-Loaded Multifunctional Nanoparticles in Combination with Decitabine for Breast Cancer Chemoimmunotherapy DOI
Xueyan Hou, Jingjing Xu,

Yuxin Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(43), P. 58392 - 58404

Published: Oct. 16, 2024

Pyroptosis, a form of programmed cell death, holds great promise for breast cancer treatment. However, the downregulation gasdermin E (GSDME) limits effectiveness pyroptosis. To address this challenge, we developed folic acid-modified and glutathione/reactive oxygen species dual-responsive nanocarrier (FPSD NPs) targeted delivery doxorubicin (DOX). Through combination with DNA methyltransferase inhibitor decitabine (DAC), GSDME protein expression was significantly increased in 4T1 cells, resulting swelling ballooning, which are characteristic features In vivo experiments further demonstrated antitumor efficacy DAC + DOX@FPSD NPs, 4T1-bearing mice treated NPs exhibited reduced tumor volumes, minimized weights, decreased Ki67-positive TUNEL apoptosis ratios, pronounced lesions H&E staining. Furthermore, NP treatment could promote pyroptosis-associated immunity, as evidenced by presence CD3+, CD4+, CD8+ T heightened secretion necrosis factor-α interferon-γ, elevated high-mobility group box-1 levels, enhanced calreticulin exposure. The FPSD study had favorable stability, active targeting ability, biocompatibility, controlled release properties, represented an approach to therapy inducing pyroptosis, offers promising avenue

Language: Английский

Citations

3
In situ forming and self-crosslinkable protein hydrogels for localized cancer therapy and topical wound healing DOI

Soomin Eom,

Seong Guk Park,

Yong Hoe Koo

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 460 - 475

Published: Dec. 21, 2024

Language: Английский

Citations

1