Supramolecular Assembly‐Enabled Transdermal Therapy of Hypertrophic Scarring Through Concurrent Ferroptosis‐Apoptosis DOI
Bin Zhao, Mengying Wei, Xiaomeng Zhou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Hypertrophic scar (HS) remains a major challenge for clinicians due to unsatisfactory therapeutic performance. Although inducing apoptosis of HS fibroblasts (HSFs) has proved be an effective nonsurgical treatment strategy, potential chemotherapy resistance HSFs makes the development new and efficient strategies highly demanding. Herein, ferroptosis‐apoptosis combined strategy is developed through supramolecular self‐assembly between cucurbit[7]uril (CB[7]) two bioactive agents, dihydroartemisinin (DHA) gold nanoclusters (AuNCs). The resulting self‐assembled nanoparticles, named CAD NPs, showed high guest loading efficiency prominent pH‐responsive degradability in acidic lysosomes HSFs. Importantly, both DHA AuNCs act synergistically generate excessive reactive oxygen species lipid peroxidation, leading mitochondrial damage, ultimately concurrent ferroptosis on Upon further into hydrogel microneedles facilitate their transdermal delivery, these NPs superior antiscar effects shortening span 3 weeks improving appearance, as demonstrated at rabbit ear model HS. present assembly‐based provides innovative guideline efficiently treating well other diseases.

Language: Английский

Advancements in Protein-Based Bionanocomposites for Targeted and Controlled Drug Delivery Systems: A Comprehensive Review DOI
Dahlang Tahir,

Syarifuddin Syarifuddin,

E Noor

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106698 - 106698

Published: Feb. 1, 2025

Language: Английский

Citations

2
Mucous Permeable Nanoparticle for Inducing Cuproptosis‐Like Death In Broad‐Spectrum Bacteria for Nebulized Treatment of Acute Pneumonia DOI Creative Commons

Huiqun Hu,

Shiyuan Hua,

Feng Lu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Abstract The emergence of antibiotic‐resistant bacteria has exacerbated the challenge treating infectious diseases. Quorum sensing (QS), a bacterial communication system regulating virulence and biofilm formation, presents target for novel therapies. Cuproptosis death is innovation mode death, however, this effect may be partially inhibited by glutathione (GSH). Buthionine sulfoximine (BSO) responsible GSH biosynthesis been identified as potential promoter cuproptosis death. Here, Cu 2 O‐BSO NPs with lung adhesion mucus penetration ability are synthesized incorporating BSO onto O, modifying it DOPA PEG. demonstrated broad‐spectrum antibacterial activity against both Gram‐positive Gram‐negative bacteria, making viable treatment option MRSA‐induced acute pneumonia. Specifically, can synergistically enhance cuproptosis‐like hinder QS system, eradicate biofilms, reduce strains, stimulate chemotaxis phagocytosis macrophages, ultimately improve in mice severe This research wide‐ranging alternative, providing promise addressing microbial resistance combatting formation. Additionally, established theoretical foundation clinical numerous challenging cases drug‐resistant bacteria.

Language: Английский

Citations

1
Copper homeostasis and copper-induced cell death in tumor immunity: implications for therapeutic strategies in cancer immunotherapy DOI Creative Commons

Sai‐Nan Zhang,

Qibo Huang,

Tuo Ji

et al.

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Oct. 31, 2024

Copper is an important trace element for maintaining key biological functions such as cellular respiration, nerve conduction, and antioxidant defense. Maintaining copper homeostasis critical human health, its imbalance has been linked to various diseases, especially cancer. Cuproptosis, a novel mechanism of copper-induced cell death, provides new therapeutic opportunities metal ion regulation interact with fate. This review insights into the complex mechanisms metabolism, molecular basis cuproptosis, association cancer development. We assess role cuproptosis-related genes (CRGs) associated tumorigenesis, their importance prognostic indicators targets, impact on tumor microenvironment (TME) immune response. Ultimately, this highlights interplay between copper, immunotherapy.

Language: Английский

Citations

5
Three‐Level Nanoparticle Rocket Strategy for Colorectal Cancer Therapeutics in Photothermal Therapy, Inflammation Modulation, and Cuproptosis Induction DOI Open Access
Wenting Shang,

Xueer Xia,

Yuting Zhu

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Disturbances in intracellular copper (Cu) homeostasis can trigger cuproptosis, a new form of cell death, which, when combined with photothermal therapy (PTT), offers promising solution to the persistent challenges colorectal cancer (CRC) treatment. In this study, “three‐level nanoparticle rocket” strategy is developed by engineering Cu 5.4 O, multifunctional Cu‐based nanoenzyme that and has electron transfer properties antioxidant efficiency. O effectively remodels inflammatory environment scavenging reactive oxygen species, thereby overcoming traditional limitations PTT. Concurrently, releases substantial amounts + into malignant cells, disrupting homeostasis, inducing ultimately inhibiting tumor progression. vivo vitro experiments demonstrate operates through multiple successive interlocking stages significantly eradicate tumors, prevent relapse, prolong survival. This study provides profound insights synergistic effects PTT, regulation, cuproptosis within complex microenvironment, presenting innovative approaches for future CRC therapy.

Language: Английский

Citations

0
Metal-phenolic networks specifically eliminate hypoxic tumors by instigating oxidative and proteotoxic stresses DOI
Jia Liu,

Zuoyu Chen,

Lixue Deng

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 361 - 377

Published: Feb. 12, 2025

Language: Английский

Citations

0
Advances in chemically modified HSA as a multifunctional carrier for transforming cancer therapy regimens DOI
Zheng Sun, Hui Fu,

Ruixuan Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141373 - 141373

Published: Feb. 21, 2025

Language: Английский

Citations

0
Advancing Cancer Therapy with Nanomaterials Targeting Metalloptosis Mechanisms DOI

Girish Sharma,

Anita Mittal,

Tarun Kumar Batra

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 503 - 530

Published: April 25, 2025

Despite the widespread use of traditional cancer therapies such as surgery, chemotherapy, and radiation, these approaches often suffer from significant drawbacks. Nanomaterials (NMs) are a promising alternative due to their distinct nanoscale properties which enable more precise drug delivery reduced off-target effects. Recently, cuproptosis ferroptosis have emerged novel forms programmed cell death regulated by metal ions, offering pathways for therapy. Cuproptosis, caused copper ion accumulation, leads mitochondrial dysfunction, while ferroptosis, driven iron-mediated lipid peroxidation, disrupts cellular integrity through oxidative stress. Here, we propose explore how NMs can be harnessed induce metalloptosis, advanced treatment strategies. Variations in NM size, morphology, synergistic effects composite complicate identification individual mechanisms. Use therapy, requires focusing on design regulation metalloptosis pathways.

Language: Английский

Citations

0
Cuproptosis-Driven Nanostrategies: Synergistic Nanoplatforms for Tumor Microenvironment Reprogramming and Enhanced Anticancer Efficacy DOI Creative Commons
Haipeng Cheng, Lin Zhao, Jing Cai

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101894 - 101894

Published: May 1, 2025

Language: Английский

Citations

0
Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer DOI Creative Commons
Xiangdong Liu, Wanqiu Zhang,

Shaozhong Wei

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 3, 2024

Colorectal cancer has emerged as one of the predominant malignant tumors globally. Immunotherapy, a novel therapeutic methodology, opened up new possibilities for colorectal patients. However, its actual clinical efficacy requires further enhancement. Copper, an exceptionally crucial trace element, can influence various signaling pathways, gene expression, and biological metabolic processes in cells, thus playing critical role pathogenesis cancer. Recent studies have revealed that cuproptosis, mode cell death, holds promise to become potential target overcome resistance immunotherapy. This shows substantial combination treatment Conveying copper into tumor cells via nano-drug delivery system induce cuproptosis could offer strategy eliminating drug-resistant vastly improving immunotherapy while ultimately destroy tumors. Moreover, combining induction with other anti-tumor approaches such photothermal therapy, photodynamic chemodynamic therapy enhance effect. review aims illuminate practical significance cuproptosis-inducing nano-drugs immunotherapy, scrutinize current challenges limitations this thereby providing innovative thoughts references advancement cuproptosis-based strategies.

Language: Английский

Citations

1
Dual-Blocked Immune Checkpoint-Engineered Nanocarriers Combined with Photodynamic Therapy To Enhance Immunotherapy of Breast Cancer DOI
Jie Li, Yufeng Gu, Wenwen Sun

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(23), P. 27476 - 27488

Published: Nov. 25, 2024

Language: Английский

Citations

0