Self‐Cascade API Nanozyme for Synergistic Anti‐Inflammatory, Antioxidant, and Ferroptosis Modulation in the Treatment of Corneal Neovascularization DOI
Hongwei Wang, Yang Yang, Huimin Yu

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Corneal neovascularization is a common pathological ocular change that can severely impairs vision, potentially leading to blindness. Although steroids and non-steroidal anti-inflammatory drugs are the primary treatments, their side effects, such as hypertension, eye irritation, corneal lysis, limit widespread use. In present study, an active pharmaceutical ingredient (API) nanozyme (PC-DS NE) developed through metal-organic coordination of ferrous sulfate with agent diclofenac sodium natural antioxidant proanthocyanidin. PC-DS NE exhibited spheroid morphology particle size 39.7 ± 5.2 nm, could achieve short-term release sustained Notably, possessed favorable biocompatibility, self-cascade redox regulation capacity, significant activity. alkali burn experiments, effectively inhibited by scavenging reactive oxygen species, inhibiting expression inflammatory cytokines pro-angiogenic factors, down-regulating ferroptosis. These synergistic effects highlighted potential promising treatment for diseases.

Language: Английский

A Promising Strategy for Ocular Noninvasive Protein Delivery: the Case in Treating Corneal Neovascularization DOI

Bangxun Mao,

Bojiao Tang, Songping Yu

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Unveiling the behavior of cubic and reverse hexagonal liquid crystalline nanoparticles in cellular and skin delivery of glucocorticoid and small interfering RNA DOI
Ana Vitória Pupo Silvestrini, Uziel Paulo da Silva, Márcia Carvalho de Abreu Fantini

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127442 - 127442

Published: March 1, 2025

Language: Английский

Citations

0
Topical Ocular Drug Delivery: The Impact of Permeation Enhancers DOI Creative Commons
Gonçalo Santos, Esmeralda Delgado, Beatriz Silva

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 447 - 447

Published: March 31, 2025

Topical ophthalmic drug delivery targeting the posterior segment of eye has become a key area interest due to its non-invasive nature, safety, ease application, patient compliance, and cost-effectiveness. However, achievement effective bioavailability in ocular is significant challenge unique barriers, including precorneal factors anatomical like cornea, conjunctiva, sclera. Successful systems require increased residence time improved corneal penetration enhance intraocular bioavailability. A promising strategy overcome these barriers incorporating enhancers (DPEs) into formulations. These compounds facilitate by improving permeability across otherwise impermeable or poorly permeable membranes. At level, they act through three primary mechanisms: breaking tear film stability interfering with mucous layer; disrupting membrane components such as phospholipids proteins; loosening epithelial cellular junctions. DPEs offer potential improve therapeutic outcomes, particularly for drugs eye. This review focused on analyzing current literature regarding use topical delivery, highlighting their mechanisms action revolutionize treatments.

Language: Английский

Citations

0
Recent advances and perspectives of multifunctional nanogels in biomedical applications DOI Creative Commons
Buxing Han,

Zideng Dai,

Hangrong Chen

et al.

MedComm – Biomaterials and Applications, Journal Year: 2024, Volume and Issue: 3(4)

Published: Nov. 28, 2024

Abstract Nanogels (NGs) are considered as a kind of nanoscale hydrogels (<200 nm) endowing with the functions both nanomaterials and hydrogels. In last 20 years, NGs have garnered significant attention due to their versatility adaptability. Herein, comprehensive overview latest advancements current research status is provided, particular focus on synthesis strategies involving physical chemical cross‐linking methods, well advantages in drug loading responsive release. Based diverse design NGs, four key biomedical applications, including inflammation therapy, regenerative medicine, bioimaging tumor therapy further summarized discussed. Moreover, existed inherent challenges facing proposed, while highlighting potential revolutionize therapeutic diagnostic approaches. Finally, we look forward development promising potentials applications. This review aims serve valuable reference for researchers, providing some insights into evolving landscape advanced

Language: Английский

Citations

1
Self‐Cascade API Nanozyme for Synergistic Anti‐Inflammatory, Antioxidant, and Ferroptosis Modulation in the Treatment of Corneal Neovascularization DOI
Hongwei Wang, Yang Yang, Huimin Yu

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Corneal neovascularization is a common pathological ocular change that can severely impairs vision, potentially leading to blindness. Although steroids and non-steroidal anti-inflammatory drugs are the primary treatments, their side effects, such as hypertension, eye irritation, corneal lysis, limit widespread use. In present study, an active pharmaceutical ingredient (API) nanozyme (PC-DS NE) developed through metal-organic coordination of ferrous sulfate with agent diclofenac sodium natural antioxidant proanthocyanidin. PC-DS NE exhibited spheroid morphology particle size 39.7 ± 5.2 nm, could achieve short-term release sustained Notably, possessed favorable biocompatibility, self-cascade redox regulation capacity, significant activity. alkali burn experiments, effectively inhibited by scavenging reactive oxygen species, inhibiting expression inflammatory cytokines pro-angiogenic factors, down-regulating ferroptosis. These synergistic effects highlighted potential promising treatment for diseases.

Language: Английский

Citations

0