Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications DOI Creative Commons
Hugo Félix Perini, Beatriz Sodré Matos, Carlo José Freire Oliveira

et al.

Beilstein Journal of Nanotechnology, Journal Year: 2024, Volume and Issue: 15, P. 1619 - 1626

Published: Dec. 16, 2024

Biomimetic nanocarriers, engineered to mimic the characteristics of native cells, offer a revolutionary approach in treatment various complex human diseases. This strategy enhances drug delivery by leveraging innate properties cellular components, thereby improving biocompatibility and targeting specificity. nanocarriers demonstrate significant advancements systems against cancer therapy, Alzheimer's disease, autoimmune diseases, viral infections such as COVID-19. Here, we address therapeutic applications biomimetic their promising for personalized medicine.

Language: Английский

Synthetic circRNA therapeutics: innovations, strategies, and future horizons DOI Creative Commons

Jingsheng Cai,

Zonghao Qiu,

William C. Cho

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(11)

Published: Nov. 1, 2024

Abstract Small molecule drugs are increasingly emerging as innovative and effective treatments for various diseases, with mRNA therapeutics being a notable representative. The success of COVID‐19 vaccines has underscored the transformative potential in RNA therapeutics. Within family, there is another unique type known circRNA. This single‐stranded closed‐loop offers advantages over mRNA, including enhanced stability prolonged protein expression, which may significantly impact therapeutic strategies. Furthermore, circRNA plays pivotal role pathogenesis such cancers, autoimmune disorders, cardiovascular making it promising clinical intervention target. Despite these benefits, application settings remains underexplored. review provides comprehensive overview current state synthetic therapeutics, focusing on its synthesis, optimization, delivery, diverse applications. It also addresses challenges impeding advancement from bench to bedside. By summarizing aspects, aims equip researchers insights into ongoing developments future directions Highlighting both progress existing gaps research, this valuable perspectives advancing field guiding investigations.

Language: Английский

Citations

10
Biomimetic Nanoparticles: A Revolutionary Approach to Breast Cancer Therapy Using Cell Membrane Coatings DOI

Jyoti Chandra,

Nagashekhara Molugulu, Garima Gupta

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106849 - 106849

Published: March 1, 2025

Language: Английский

Citations

1
From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery DOI Creative Commons
Lijuan Xie,

Fengxu Gan,

Dafang Zhuang

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 15 - 15

Published: Jan. 6, 2025

Biomimetic nanodrug delivery systems based on cell membranes have emerged as a promising approach for targeted cancer therapy due to their biocompatibility and low immunogenicity. Among them, platelet-mediated are particularly noteworthy innate tumor-homing interaction capabilities. These utilize nanoparticles shielded directed by platelet membrane coatings efficient drug delivery. This review highlights the role of platelets in therapy, summarizes advancements platelet-based systems, discusses integration with other treatments. Additionally, it addresses limitations challenges delivery, offering insights into future developments this innovative field.

Language: Английский

Citations

0
Demystifying the Potential of Polymeric Lipids as Substitute in Regenerative Applications: A Review DOI Open Access
Popat Mohite, Abhijeet Puri, Deepak Bharati

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 1, 2025

ABSTRACT The objective of a regenerative medicine is to repair, restore, and regenerate tissues organs that occurred due injury or defect disease. Additionally, the purpose reverse aging process body by utilizing body's innate healing ability. There still significant venture needs be directed for advancement in arena medicine, which makes use products derived from cell therapy as well biomedical. Stem cells growth factors are primary components medicine; hence, novel drug delivering systems now being studied augment transport active pharmaceuticals. Lipid‐based complexed with therapeutics suited site‐specific controlled release. Lipids biocompatible available various sources molecular weights self‐assemble into forms hydrophilic hydrophobic parts. By enhancing plasma membrane fluidity, excipients such non‐ionic surfactants, fatty acids, glycerides increase permeability. Liposomes, nanoparticles, nano‐emulsions, micelles nano‐lipid carriers can improve bioavailability both lipophilic medicines. lipoidal‐polymeric had emerged promising multifaceted application cytocompatibility, ecofriendly, ability encapsulate variety drugs. Further, treatment biomedical tissue engineering, rapidly developing discipline. Furthermore, similar vein, delivery technologies combined stem promote engraftment, differentiation, survival. Hence colloidal carrier has impending versatile applications. Therefore, review offer an abridged information on significance technology offering confined ecosystem facilitates them thrive distinguish effective manner.

Language: Английский

Citations

0
Biomimetic Nanoplatform for Targeted Rheumatoid Arthritis Therapy: Modulating Macrophage Niches Through Self‐Sustaining Positive Feedback‐Driven Drug Release Mechanisms DOI Creative Commons
Huichao Xie, Xiaoyu Huang, Bao Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Abstract The core strategies in treating rheumatoid arthritis (RA) now focus on ameliorating the inflammatory microenvironment and reversing macrophage phenotypes within joint cavity. This study introduces a co‐delivery system of integrating nanoenzymes gene therapeutics sequentially modified with guanidinium‐based polymers membranes to achieve synergistic therapeutic effects. is named MACP siTNF‐α nanoparticles (NPs). are designed for targeted delivery inflamed site, where they preferentially internalized by M1‐type macrophages efficiently evade lysosomal degradation. Subsequently, operates via self‐sustaining positive feedback drug release mechanism. biomimetic nanoplatform reduces reactive oxygen species (ROS) levels prevents glutathione (GSH) depletion. GSH degrades small interfering RNA (siRNA) expose Prussian blue (PB) nanoenzymes, which effectively scavenge ROS restore levels. loop significantly enhances silencing capability scavenging efficiency system. In summary, NPs can reverse ecological niche soils through dual mechanism inhibiting expression tumor necrosis factor‐alpha (TNF‐α) upstream pathway response, eliminating ROS, thus realizing efficient treatment RA.

Language: Английский

Citations

0
Nanoparticle‐Based drug delivery strategies for targeted therapy to hypoxic solid tumors DOI

ZhouXue Wu,

Junru Chen,

Biqiong Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158081 - 158081

Published: Nov. 1, 2024

Language: Английский

Citations

2
Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications DOI Creative Commons
Hugo Félix Perini, Beatriz Sodré Matos, Carlo José Freire Oliveira

et al.

Beilstein Journal of Nanotechnology, Journal Year: 2024, Volume and Issue: 15, P. 1619 - 1626

Published: Dec. 16, 2024

Biomimetic nanocarriers, engineered to mimic the characteristics of native cells, offer a revolutionary approach in treatment various complex human diseases. This strategy enhances drug delivery by leveraging innate properties cellular components, thereby improving biocompatibility and targeting specificity. nanocarriers demonstrate significant advancements systems against cancer therapy, Alzheimer's disease, autoimmune diseases, viral infections such as COVID-19. Here, we address therapeutic applications biomimetic their promising for personalized medicine.

Language: Английский

Citations

0