Cancer vaccines: platforms and current progress

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 10, 2025

Abstract Cancer vaccines, crucial in the immunotherapeutic landscape, are bifurcated into preventive and therapeutic types, both integral to combating oncogenesis. Preventive cancer like those against HPV HBV, reduce incidence of virus-associated cancers, while vaccines aim activate dendritic cells cytotoxic T lymphocytes for durable anti-tumor immunity. Recent advancements vaccine platforms, such as synthetic peptides, mRNA, DNA, cellular, nano-vaccines, have enhanced antigen presentation immune activation. Despite US Food Drug Administration approval several full potential remains unrealized due challenges selection, tumor-mediated immunosuppression, optimization delivery systems. This review provides a comprehensive analysis aims implications vaccine, innovative discovery neoantigens enhancing specificity, latest strides platforms. It also critically evaluates role adjuvants immunogenicity mitigating immunosuppressive tumor microenvironment. The further examines synergistic combining with other therapies, chemotherapy, radiotherapy, checkpoint inhibitors, improve outcomes. Overcoming barriers effective identification, microenvironments, adverse effects is critical advancing development. By addressing these challenges, can offer significant improvements patient outcomes broaden scope personalized immunotherapy.

Language: Английский

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Nitroxide radical contrast agents for safe magnetic resonance imaging: progress, challenges, and perspectives

Materials Horizons, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Magnetic resonance imaging (MRI) is considered one of the most valuable diagnostic technologies in 21st century. To enhance image contrast anatomical features, MRI agents have been widely used clinical diagnosis, especially those based on gadolinium, manganese, and iron oxide. However, these metal-based show potential toxicity to patients, which urges researchers develop novel that can replace agents. Metal-free nitroxide radical (NRCAs) effectively overcome shortcomings also many advantages, including good biocompatibility, prolonged systemic circulation time, easily functionalized structures. Importantly, since NRCAs acquire signals with standard tissue water

Language: Английский

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Revolutionizing cancer treatment: The power of dendritic cell-based vaccines in immunotherapy

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117858 - 117858

Published: Feb. 16, 2025

Language: Английский

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Tumor organoid-immune co-culture models: exploring a new perspective of tumor immunity

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 23, 2025

Abstract Recent advancements in technology have significantly expanded the scope of tumor research, progressing from study individual cells to more intricate tissue and organ-level analyses. Tumor organoids emerged as a highly realistic platform for investigating growth, development, their interactions with surrounding microenvironment. However, notable limitation these is lack diverse cellular composition typically observed actual tumors, which hinders ability fully replicate complexity Immune play pivotal role, immunology has become major research hotspot. Research aims elucidate how immune system recognizes attacks cells, well evade surveillance. In recent years, there been growing interest co-culturing organoids, an approach that yielded valuable insights into between tumors system. The aim this paper review discuss progress achieved cells. By doing so, we hope offer new perspective enhance our understanding diversity inherent

Language: Английский

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Research Progress of Nitroxide Radical-Based MRI Contrast Agents: From Structure Design to Application

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Nitroxide radicals-based agnetic resonance imaging remains a cornerstone of diagnostic imaging, offering unparalleled insights into anatomical structures and pathological conditions.

Language: Английский

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Nanovaccines: Antigen selection, stabilization, adjuvantation, formulation, and evaluation

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 541, P. 216806 - 216806

Published: May 21, 2025

Language: Английский

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Chitosan-coated PLA/poloxamer nanoparticles stimulate immunologic cancer cell death and synergistic chemo-immunotherapeutic efficacy

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138346 - 138346

Published: Dec. 1, 2024

Language: Английский

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