Improving the Efficacy of Cancer mRNA Vaccines

The Cancer Journal, Journal Year: 2025, Volume and Issue: 31(2)

Published: March 1, 2025

mRNA vaccines consist of antigen-encoding mRNA, which produces the antigenic protein upon translation. Coupling antigen production with innate immune activation can generate a potent, antigen-specific T-cell response. Clinical reports have demonstrated ability to elicit an anticancer response against various tumor types. Here, we discuss strategies enhance potency vaccines. We provide overview existing knowledge regarding and trafficking mechanisms share optimization boost mRNA-mediated production. In addition, address methods target dendritic cells lymph nodes, key initiators Finally, review for enhancing using adjuvants compatible offer unique advantages that be utilized oncology applications. However, significant work is needed understand their underlying develop technologies improve effectiveness.

Language: Английский

Pickering emulsion with tumor vascular destruction and microenvironment modulation for transarterial embolization therapy

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123018 - 123018

Published: Dec. 18, 2024

Language: Английский