GRP94 mediates blood-brain barrier permeation and substantia nigra-specific drug distribution in Parkinson’s disease
Ziyan Lv,
No information about this author
Yuteng Zeng,
No information about this author
Tangfeng Lv
No information about this author
et al.
Colloids and Surfaces B Biointerfaces,
Journal Year:
2025,
Volume and Issue:
unknown, P. 114585 - 114585
Published: Feb. 1, 2025
Language: Английский
Biomimetic membrane-coated nanoparticles specially permeate the inflammatory blood-brain barrier to deliver plasmin therapy for brain metastases
Mei Zhao,
No information about this author
Yuanyuan Lin,
No information about this author
Yuteng Zeng
No information about this author
et al.
Journal of Controlled Release,
Journal Year:
2024,
Volume and Issue:
378, P. 763 - 775
Published: Dec. 29, 2024
Language: Английский
Wnt-Regulated Therapeutics for Blood-Brain Barrier Modulation and Cancer Therapy
Pei An,
No information about this author
Yang Tong,
No information about this author
Rui Mu
No information about this author
et al.
Bioconjugate Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
The
Wnt
signaling
pathway
has
a
significant
regulatory
part
in
tissue
development
and
homeostasis.
Dysregulation
of
the
been
associated
with
many
diseases
including
cancers
various
brain
diseases,
making
this
promising
therapeutic
target
for
these
diseases.
In
review,
we
describe
roles
blood-brain
barrier
(BBB)
intracranial
tumors
peripheral
tumors,
from
preclinical
clinical
perspectives,
introduce
Wnt-regulated
therapeutics
types
drugs
nanomedicines
as
BBB
modulators
brain-oriented
drug
delivery
cancer
treatments,
finally
discuss
limitations
future
perspectives
therapeutics.
Language: Английский
Bacterial and bacterial derivatives-based drug delivery systems: a novel approach for treating central nervous system disorders
Shizhu Gao,
No information about this author
Xin Li,
No information about this author
Bing Han
No information about this author
et al.
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 17, 2024
Bacteria
and
their
derivatives
show
great
potential
as
drug
delivery
systems
due
to
unique
chemotaxis,
biocompatibility,
targeting
abilities.
In
CNS
disease
treatment,
bacterial
carriers
can
cross
the
blood-brain
barrier
(BBB)
deliver
drugs
precisely,
overcoming
limitations
of
traditional
methods.
Advances
in
genetic
engineering,
synthetic
biology,
nanotechnology
have
transformed
these
into
multifunctional
platforms
for
personalized
treatment.
Language: Английский