Immunity‐Modulating Metal‐Based Nanomaterials for Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Cancer immunotherapy, which leverages the body's immune system to combat cancer, offers promise of lower toxicity and higher therapeutic efficacy compared conventional treatments. However, current immunotherapeutic approaches face significant challenges including variable patient response, immune‐related adverse events, high costs, underscoring urgent need for innovative strategies. Metal‐based nanomaterials have emerged as a promising avenue in cancer immunotherapy due their unique physicochemical properties immune‐regulating capabilities. Despite potential, concerns about toxicity, incomplete understanding modulation mechanisms, early‐stage design strategies hinder clinical translation. This review summarizes recent advancements metal‐based elucidates mechanisms by they enhance antitumor immunity responses, explores potential synergistic effects combining multiple metals. We also discuss key future perspectives application, aiming provide theoretical foundation development immunotherapies promote broader application treatment.

Language: Английский

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Unleashing the Potential of Metal Ions in cGAS-STING Activation: Advancing Nanomaterial-Based Tumor Immunotherapy

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Immunotherapy is a critical modality in cancer treatment with diverse activation pathways. In recent years, the stimulator of interferon genes (STING) signaling pathway has exhibited significant potential tumor immunotherapy. This exerts notable antitumor effects by activating innate and adaptive immunity regulating immune microenvironment. Various metal ions have been identified as effective activators STING and, through design synthesis nanodelivery platforms, applied immunotherapy well combination therapies, such chemotherapy, chemodynamic therapy, photodynamic vaccines. Metal nanomaterials showcase unique advantages immunotherapy; however, there are still aspects that require optimization. review systematically examines existing metal-based nanomaterials, elaborates on mechanisms which different activate pathway, discusses their application models therapies. We also provide comparative analysis over other methods. Our exploration highlights broad prospects treatment, offering new insights directions for advancement

Language: Английский

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Metal-based nanocomposites for immunotherapy of osteosarcoma

Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 7(6)

Published: Oct. 23, 2024

Language: Английский

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Nitric oxide-based multi-synergistic nanomedicine: an emerging therapeutic for anticancer

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 4, 2024

Gas therapy has emerged as a promising approach for treating cancer, with gases like NO, H2S, and CO showing positive effects. Among these, NO is considered key gas molecule significant potential in stopping cancer progression. However, due to its high reactivity short half-life, delivering directly tumors crucial enhancing treatment. NO-driven nanomedicines (NONs) have been developed effectively deliver donors tumors, great progress recent years. This review provides an overview of the latest advancements NO-based nanotherapeutics. It discusses types used current research, mechanisms action behind different delivery systems also explores combining other treatments enhanced therapy. Finally, it examines future prospects challenges using NONs clinical settings

Language: Английский

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