Microneedling Drug Delivery System: Strategies, Design, Manufacturing, Clinical Aspects and Treatment for Cancer Therapy DOI Open Access
Priyanshu Sharma,

Abhishek Singh,

Kapil Kumar Verma

et al.

Journal of Drug Delivery and Therapeutics, Journal Year: 2024, Volume and Issue: 14(12), P. 156 - 165

Published: Dec. 15, 2024

Microneedling, a minimally invasive technique traditionally used in dermatology, has emerged as promising approach to cancer therapy. The procedure involves creating microchannels the skin using fine needles, enhancing delivery of therapeutic agents directly into tumor tissues. This method overcomes limitations conventional treatments, such systemic toxicity and poor drug penetration, by facilitating localized controlled delivery. Microneedling can also stimulate immune responses induce tissue regeneration, potentially effectiveness immunotherapy promoting suppression. Recent studies have shown that microneedling be combined with nanoparticles, chemotherapeutics, or gene therapies, allowing for more precise targeted treatment cells while minimizing damage healthy Additionally, microneedling-based systems improve bioavailability drugs, reducing required dosages associated side effects. been instrumental treating cancers, melanoma, but its potential application other solid tumors is currently being explored. While promising, further clinical are needed optimize parameters evaluate long-term safety efficacy As field progresses, may revolutionize therapeutics, offering cost-effective, patient-friendly option complements existing treatments. Keywords: Cancer therapy, Nanoparticles, Immunotherapy.

Language: Английский

Microneedling Drug Delivery System: Strategies, Design, Manufacturing, Clinical Aspects and Treatment for Cancer Therapy DOI Open Access
Priyanshu Sharma,

Abhishek Singh,

Kapil Kumar Verma

et al.

Journal of Drug Delivery and Therapeutics, Journal Year: 2024, Volume and Issue: 14(12), P. 156 - 165

Published: Dec. 15, 2024

Microneedling, a minimally invasive technique traditionally used in dermatology, has emerged as promising approach to cancer therapy. The procedure involves creating microchannels the skin using fine needles, enhancing delivery of therapeutic agents directly into tumor tissues. This method overcomes limitations conventional treatments, such systemic toxicity and poor drug penetration, by facilitating localized controlled delivery. Microneedling can also stimulate immune responses induce tissue regeneration, potentially effectiveness immunotherapy promoting suppression. Recent studies have shown that microneedling be combined with nanoparticles, chemotherapeutics, or gene therapies, allowing for more precise targeted treatment cells while minimizing damage healthy Additionally, microneedling-based systems improve bioavailability drugs, reducing required dosages associated side effects. been instrumental treating cancers, melanoma, but its potential application other solid tumors is currently being explored. While promising, further clinical are needed optimize parameters evaluate long-term safety efficacy As field progresses, may revolutionize therapeutics, offering cost-effective, patient-friendly option complements existing treatments. Keywords: Cancer therapy, Nanoparticles, Immunotherapy.

Language: Английский

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