Microfluidics for Nanomedicine Delivery

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Nanomedicine is revolutionizing precision medicine, providing targeted, personalized treatment options. Lipid-based nanomedicines offer distinct benefits including high potency, targeted delivery, extended retention in the body, reduced toxicity, and lower required doses. These characteristics make lipid-based nanoparticles ideal for drug delivery areas such as gene therapy, cancer treatment, mRNA vaccines. However, traditional bulk synthesis methods LNPs often produce larger particle sizes, significant polydispersity, low encapsulation efficiency, which can reduce therapeutic effectiveness. issues primarily result from uneven mixing limited control over formation during synthesis. Microfluidic technology has emerged a solution, precise size, uniformity, efficiency. In this mini review, we introduce state-of-the-art microfluidic systems nanoparticle functionalization. We include working principles of different types systems, use LNP synthesis, cargo encapsulation, nanomedicine delivery. end, briefly discuss clinical enabled by devices.

Language: Английский

Self-degradable “gemini-like” ionizable lipid-mediated delivery of siRNA for subcellular-specific gene therapy of hepatic diseases

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Interaction design in mRNA delivery systems

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 413 - 426

Published: Nov. 26, 2024

Language: Английский