Challenges and considerations in liposomal hydrogels for the treatment of infection DOI Creative Commons
Željka Vanić, May Wenche Jøraholmen, Nataša Škalko‐Basnet

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Jan. 10, 2025

Liposomal hydrogels are novel drug delivery systems that comprise preformed liposomes incorporated in destined for mostly localized therapy, herewith antimicrobial therapy. The formulation benefits from versatility of as lipid-based nanocarriers enable various antimicrobials different lipophilicities, and secondary vehicle, hydrogel, assures better retention time at the infection site. Especially an era alarming resistance, efficient therapy avoids systemic exposure related side effects is crucial. We provide overview liposomal were developed superior infections sites, with focus on skin vaginal infections. review summarizes challenges site most common infection-causing pathogens offers commentary relevant features needs to optimize increase outcome. discuss impact composition, size, choice polymer-forming hydrogel outcome based literature own experience field. offer improved By fine-tuning well properties, formulations performance can be optimized targeting specific

Language: Английский

Challenges and considerations in liposomal hydrogels for the treatment of infection DOI Creative Commons
Željka Vanić, May Wenche Jøraholmen, Nataša Škalko‐Basnet

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Jan. 10, 2025

Liposomal hydrogels are novel drug delivery systems that comprise preformed liposomes incorporated in destined for mostly localized therapy, herewith antimicrobial therapy. The formulation benefits from versatility of as lipid-based nanocarriers enable various antimicrobials different lipophilicities, and secondary vehicle, hydrogel, assures better retention time at the infection site. Especially an era alarming resistance, efficient therapy avoids systemic exposure related side effects is crucial. We provide overview liposomal were developed superior infections sites, with focus on skin vaginal infections. review summarizes challenges site most common infection-causing pathogens offers commentary relevant features needs to optimize increase outcome. discuss impact composition, size, choice polymer-forming hydrogel outcome based literature own experience field. offer improved By fine-tuning well properties, formulations performance can be optimized targeting specific

Language: Английский

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