Harnessing the Power of Natural Products for Targeted Protein Degradation DOI

Bo Zhu,

Zheng Wu,

Yiwen Shou

et al.

Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

ABSTRACT Natural products have garnered significant attention due to their complex chemical structures and remarkable pharmacological activities. With inherent recognition capabilities for protein surfaces, natural serve as ideal candidates designing proteolysis‐targeting chimeras (PROTACs). The utilization of in PROTAC development offers distinct advantages, including rich diversity, multitarget activities, sustainable sourcing. This comprehensive review explores the vast potential harnessing research. Moreover, discusses application degradant technology, which involves utilizing product‐based compounds selectively degrade disease‐causing proteins, well implementation computer‐aided drug design (CADD) technology identifying suitable targets degradation within realm products. By power leveraging computational tools, PROTACs derived from revolutionize discovery provide innovative therapeutic interventions various diseases.

Language: Английский

The role of B2M in cancer immunotherapy resistance: function, resistance mechanism, and reversal strategies DOI Creative Commons
Xiaowen Han,

Jiayi Zhang,

Weidong Li

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Immunotherapy has emerged as a preeminent force in the domain of cancer therapeutics and achieved remarkable breakthroughs. Nevertheless, high resistance become most substantial impediment restricting its clinical efficacy. Beta-2 microglobulin (B2M), light chain major histocompatibility complex (MHC) class I, plays an indispensable part by presenting tumor antigens to cytotoxic T lymphocytes (CTLs) for exerting anti-tumor effects. Accumulating evidence indicates that B2M mutation/defect is one key mechanisms underlying immunotherapy resistance. Therefore, elucidating role played devising effective strategies battle against are pressing issues. This review will systematically expound upon them, aiming provide insight into potential promising target anticancer immune response.

Language: Английский

Citations

2
Harnessing the Power of Natural Products for Targeted Protein Degradation DOI

Bo Zhu,

Zheng Wu,

Yiwen Shou

et al.

Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

ABSTRACT Natural products have garnered significant attention due to their complex chemical structures and remarkable pharmacological activities. With inherent recognition capabilities for protein surfaces, natural serve as ideal candidates designing proteolysis‐targeting chimeras (PROTACs). The utilization of in PROTAC development offers distinct advantages, including rich diversity, multitarget activities, sustainable sourcing. This comprehensive review explores the vast potential harnessing research. Moreover, discusses application degradant technology, which involves utilizing product‐based compounds selectively degrade disease‐causing proteins, well implementation computer‐aided drug design (CADD) technology identifying suitable targets degradation within realm products. By power leveraging computational tools, PROTACs derived from revolutionize discovery provide innovative therapeutic interventions various diseases.

Language: Английский

Citations

0