Melatonin hyalurosomes as a powerful antioxidant for combating skin damage induced by UV radiation DOI
Mariam Zewail,

Haidy Abbas,

Merhan E. Ali

et al.

Journal of Liposome Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: April 1, 2025

Extrinsic skin aging is caused by chronic photodamage. The present study aims to inspect the role of nanoencapsulation melatonin (MEL) in hyalurosomes combating UVB-induced damage take advantage hydrating penetration enhancing and antiaging effects hyaluronic acid along with powerful antioxidant MEL. Measurement particle size, zeta potential, encapsulation efficiency vitro MEL release were carried out. vivo photoprotective tested rats. A histopathological examination was conducted, anti-inflammatory markers measured estimating expression P38 MAPK, P-ERK P-JNK. Particle size potential 285.9 nm -26.3 mV 95% entrapment provided a sustained profile for 48h. In vivo, results revealed superior effect protecting against reducing levels inflammatory mediators like TNF-α IL6 compared suspension. However, they had prominent increasing antioxidants. These findings may be accredited deposition besides as tool.

Language: Английский

Navigating COVID-19: advancements in therapeutics and viral filtration technologies for Today's challenges and tomorrow's solutions DOI
Devesh U. Kapoor, Bhavna Kumar, Manmohan Singhal

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106741 - 106741

Published: Feb. 1, 2025

Language: Английский

Citations

0
Melatonin hyalurosomes as a powerful antioxidant for combating skin damage induced by UV radiation DOI
Mariam Zewail,

Haidy Abbas,

Merhan E. Ali

et al.

Journal of Liposome Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: April 1, 2025

Extrinsic skin aging is caused by chronic photodamage. The present study aims to inspect the role of nanoencapsulation melatonin (MEL) in hyalurosomes combating UVB-induced damage take advantage hydrating penetration enhancing and antiaging effects hyaluronic acid along with powerful antioxidant MEL. Measurement particle size, zeta potential, encapsulation efficiency vitro MEL release were carried out. vivo photoprotective tested rats. A histopathological examination was conducted, anti-inflammatory markers measured estimating expression P38 MAPK, P-ERK P-JNK. Particle size potential 285.9 nm -26.3 mV 95% entrapment provided a sustained profile for 48h. In vivo, results revealed superior effect protecting against reducing levels inflammatory mediators like TNF-α IL6 compared suspension. However, they had prominent increasing antioxidants. These findings may be accredited deposition besides as tool.

Language: Английский

Citations

0