Topical Ocular Drug Delivery: The Impact of Permeation Enhancers DOI Creative Commons
Gonçalo Santos, Esmeralda Delgado, Beatriz Silva

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 447 - 447

Published: March 31, 2025

Topical ophthalmic drug delivery targeting the posterior segment of eye has become a key area interest due to its non-invasive nature, safety, ease application, patient compliance, and cost-effectiveness. However, achievement effective bioavailability in ocular is significant challenge unique barriers, including precorneal factors anatomical like cornea, conjunctiva, sclera. Successful systems require increased residence time improved corneal penetration enhance intraocular bioavailability. A promising strategy overcome these barriers incorporating enhancers (DPEs) into formulations. These compounds facilitate by improving permeability across otherwise impermeable or poorly permeable membranes. At level, they act through three primary mechanisms: breaking tear film stability interfering with mucous layer; disrupting membrane components such as phospholipids proteins; loosening epithelial cellular junctions. DPEs offer potential improve therapeutic outcomes, particularly for drugs eye. This review focused on analyzing current literature regarding use topical delivery, highlighting their mechanisms action revolutionize treatments.

Language: Английский

Topical Ocular Drug Delivery: The Impact of Permeation Enhancers DOI Creative Commons
Gonçalo Santos, Esmeralda Delgado, Beatriz Silva

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 447 - 447

Published: March 31, 2025

Topical ophthalmic drug delivery targeting the posterior segment of eye has become a key area interest due to its non-invasive nature, safety, ease application, patient compliance, and cost-effectiveness. However, achievement effective bioavailability in ocular is significant challenge unique barriers, including precorneal factors anatomical like cornea, conjunctiva, sclera. Successful systems require increased residence time improved corneal penetration enhance intraocular bioavailability. A promising strategy overcome these barriers incorporating enhancers (DPEs) into formulations. These compounds facilitate by improving permeability across otherwise impermeable or poorly permeable membranes. At level, they act through three primary mechanisms: breaking tear film stability interfering with mucous layer; disrupting membrane components such as phospholipids proteins; loosening epithelial cellular junctions. DPEs offer potential improve therapeutic outcomes, particularly for drugs eye. This review focused on analyzing current literature regarding use topical delivery, highlighting their mechanisms action revolutionize treatments.

Language: Английский

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