Unlocking the potential of remdesivir: innovative approaches to drug delivery DOI Creative Commons
Maie S. Taha, Ahsan R. Akram,

Ghada A. Abdelbary

et al.

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Given the recurrent waves of COVID-19 and emergence new viral infections, optimizing potential remdesivir as an antiviral agent is critical. While several reviews have explored efficacy remdesivir, few comprehensively addressed its challenges, such necessity for intravenous infusion, suboptimal lung accumulation, safety concerns related to formulation. This review critically examines these challenges while proposing innovative solutions effective combinations with other agents repurposed drugs. By highlighting role complex generics, we aim enhance therapeutic in ways not previously discussed existing literature. Furthermore, address development novel drug delivery systems which specifically improve remdesivir's pharmacological profile. analyzing recent findings, assess both successes limitations current approaches, providing insights into ongoing strategies further optimization. uniquely focuses on targeted formulations, thereby maximizing benefits broadening application combating emerging threats. In doing so, fill a critical gap literature, offering comprehensive overview that informs future research clinical strategies. Graphical

Language: Английский

Unlocking the potential of remdesivir: innovative approaches to drug delivery DOI Creative Commons
Maie S. Taha, Ahsan R. Akram,

Ghada A. Abdelbary

et al.

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Given the recurrent waves of COVID-19 and emergence new viral infections, optimizing potential remdesivir as an antiviral agent is critical. While several reviews have explored efficacy remdesivir, few comprehensively addressed its challenges, such necessity for intravenous infusion, suboptimal lung accumulation, safety concerns related to formulation. This review critically examines these challenges while proposing innovative solutions effective combinations with other agents repurposed drugs. By highlighting role complex generics, we aim enhance therapeutic in ways not previously discussed existing literature. Furthermore, address development novel drug delivery systems which specifically improve remdesivir's pharmacological profile. analyzing recent findings, assess both successes limitations current approaches, providing insights into ongoing strategies further optimization. uniquely focuses on targeted formulations, thereby maximizing benefits broadening application combating emerging threats. In doing so, fill a critical gap literature, offering comprehensive overview that informs future research clinical strategies. Graphical

Language: Английский

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