Dynamic regulation of neutrophil immunometabolism by platelet-derived metabolites DOI Creative Commons
Manuel Alejandro Mosso-Pani, Dante Barreda, Ma. Isabel Salazar

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 27, 2025

Platelets, traditionally known for their roles in hemostasis and thrombosis, have emerged as key regulators of immune responses, particularly through dynamic interactions with neutrophils. This review explores how platelets influence neutrophil functions by forming platelet-neutrophil aggregates, releasing extracellular vesicles, secreting metabolites. These processes govern critical activities, including cell recruitment, activation, endothelium the resolution or exacerbation inflammation. Additionally, induce metabolic reprogramming neutrophils, affecting glycolysis mitochondrial pathways, while also shaping microenvironment modulating other cells, such T B cells. Understanding this complex crosstalk between neutrophils—two most abundant types bloodstream—might reveal new therapeutic opportunities to regulate responses inflammatory immune-mediated diseases.

Language: Английский

Dynamic regulation of neutrophil immunometabolism by platelet-derived metabolites DOI Creative Commons
Manuel Alejandro Mosso-Pani, Dante Barreda, Ma. Isabel Salazar

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 27, 2025

Platelets, traditionally known for their roles in hemostasis and thrombosis, have emerged as key regulators of immune responses, particularly through dynamic interactions with neutrophils. This review explores how platelets influence neutrophil functions by forming platelet-neutrophil aggregates, releasing extracellular vesicles, secreting metabolites. These processes govern critical activities, including cell recruitment, activation, endothelium the resolution or exacerbation inflammation. Additionally, induce metabolic reprogramming neutrophils, affecting glycolysis mitochondrial pathways, while also shaping microenvironment modulating other cells, such T B cells. Understanding this complex crosstalk between neutrophils—two most abundant types bloodstream—might reveal new therapeutic opportunities to regulate responses inflammatory immune-mediated diseases.

Language: Английский

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