The first report of SARS-CoV-2 genome in the groundwater of Tehran, Iran: A call to action for public health DOI
S. Mahdi Hosseinian, Seyed Masoud Hosseini,

Paria Barooni Rashno

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract A pandemic of acute respiratory disease referred to as COVID-19 has been caused by the highly infectious and transmissible Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which threatened human health. Although SARS-CoV-2 RNA found in wastewater from numerous regions different countries due fecal shedding infected individuals, there is still little information available regarding how prevalent it other water matrices especially groundwater, where some areas rely on supply drinking water, irrigation farmlands, purposes. This study attempted assess presence this virus genome groundwater samples Tehran, Iran. These were collected seasonally 12 sites over years period (2021–2023). At first, a adsorption-elution (VIRADEL) concentration procedure was tested utilizing an avian coronavirus (infectious bronchitis virus, IBV) process control followed extraction. Subsequently, quantified using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) detect E S genes. As result, detected 1 out 96 with 2/53 × 103 3/16 copies/l for genes, respectively. Furthermore, positive sample subjected semi-nested PCR targeting partial gene, direct sequencing, phylogenetic mutation analysis. BA.1 Omicron only identified variant during study. findings show important water-based epidemiology monitor at community-level subsequent exposure, even when prevalence low.

Language: Английский

Chronic Hepatitis B and COVID-19 Clinical Outcomes in the United States: A Multisite Retrospective Cohort Study DOI Creative Commons
George A. Yendewa, Temitope Olasehinde, Frank Mulindwa

et al.

Open Forum Infectious Diseases, Journal Year: 2025, Volume and Issue: 12(2)

Published: Jan. 10, 2025

There is conflicting evidence regarding the impact of chronic hepatitis B virus (HBV) on SARS-CoV-2 outcomes. Additionally, vaccination and variant periods outcomes in HBV/SARS-CoV-2 coinfection remain unexplored. We utilized TriNetX database to compare adults with (vs alone) across 97 US healthcare systems from 2020 2023. assessed odds all inpatient hospitalizations, intensive care unit admissions, mechanical ventilation, 30-day, 90-day, overall mortality. In sensitivity analyses, we excluded HIV, C virus, transplant cases stratified cohort by cirrhosis status. applied propensity score matching address confounding reported ratios (OR) 95% confidence intervals (CI). Of 4 206 774 individuals SARS-CoV-2, about 0.2% (8293) were HBV/SARS-CoV-2. Individuals had higher admissions (OR, 1.18; CI, 1.02-1.36), 90-day 1.22; 1.01-1.41) mortality 1.06-1.33). those a 2.0- 2.50-fold adverse Notably, even without Vaccinated unvaccinated) 57%, 54%, 29% reduction mortality, respectively. The pre-Delta period was associated hospitalization compared Omicron but not Delta period. Chronic HBV worse outcomes, whereas reduced likelihood

Language: Английский

Citations

0
Emerging mRNA Technology for Liver Disease Therapy DOI
Ji Wang, Yile Fang, Zhiqiang Luo

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(27), P. 17378 - 17406

Published: June 25, 2024

Liver diseases have consistently posed substantial challenges to global health. It is crucial find innovative methods effectively prevent and treat these diseases. In recent times, there has been an increasing interest in the use of mRNA formulations that accumulate liver tissue for treatment hepatic this review, we start by providing a detailed introduction technology. Afterward, highlight types diseases, discussing their causes, risks, common therapeutic strategies. Additionally, summarize latest advancements technology This includes systems based on hepatocyte growth factor, hepatitis B virus antibody, left–right determination factor 1, human nuclear α, interleukin-12, methylmalonyl-coenzyme A mutase, etc. Lastly, provide outlook potential while also highlighting various technical need be addressed. Despite difficulties, mRNA-based strategies may change traditional methods, bringing hope patients with

Language: Английский

Citations

2
Seroprevalence of SARS-CoV-2 and Hepatitis B Virus Coinfections among Ethiopians with Acute Leukemia DOI Open Access
Jemal Alemu, Balako Gumi, Aster Tsegaye

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(8), P. 1606 - 1606

Published: April 22, 2024

SARS-CoV-2 and blood-borne viral coinfections are well reported. Nevertheless, little is known regarding the seroprevalence of coinfection with viruses in hematologic malignancy patients Ethiopia. We aimed to assess associated infections hepatitis B other among adolescent adult acute leukemia at Tikur Anbessa Specialized Hospital, Addis Ababa, A cross-sectional study was conducted from July 2020 June 2021. Blood samples were tested for presence anti-SARS-CoV-2, HBV, HCV, HIV ELISA kits occult infection a real-time polymerase chain reaction assay. Out total 110 cases, 35.5%. The prevalence showed significant increment end 2021 (p = 0.015). In 22.7% 2.7% HBV HIV, respectively, detected. No HCV identified. rate 28% (11/39) 2.6% (1/39), respectively; however, there no statistically association between seropositivity > 0.05). There need screening cases monitor inform management.

Language: Английский

Citations

1
Global co-dynamics of viral infections with saturated incidence DOI Creative Commons
A. M. Ełaiw,

Ghadeer S. Alsaadi,

Aatef Hobiny

et al.

AIMS Mathematics, Journal Year: 2024, Volume and Issue: 9(6), P. 13770 - 13818

Published: Jan. 1, 2024

<abstract><p>Several mathematical models of two competing viruses (or viral strains) that have been published in the literature assume infection rate is determined by bilinear incidence. These do not show co-existence equilibrium; moreover, they might be applicable situations where virus concentration high. In this paper, we developed a model for co-dynamics with saturated The included latently infected cells and three types time delays: discrete distributed): (ⅰ) formation cells; (ⅱ) activation (ⅲ) maturation newly released virions. We established well-posedness biological acceptability examining boundedness nonnegativity solutions. Four equilibrium points were identified, their stability was examined. Through application Lyapunov's approach LaSalle's invariance principle, demonstrated global equilibria. impact saturation incidence, cells, delay on could result persistent coinfections. conditions under which these coexist. coexistence formulated terms constants. findings offered new perspectives circumstances coexisting live stable populations. It shown adding class to coinfection reduced basic reproduction number each type. Therefore, fewer treatment efficacies would needed keep system at infection-free remove from body when utilizing delay. To demonstrate associated outcomes, numerical simulations conducted delays.</p></abstract>

Language: Английский

Citations

0
The first report of SARS-CoV-2 genome in the groundwater of Tehran, Iran: A call to action for public health DOI
S. Mahdi Hosseinian, Seyed Masoud Hosseini,

Paria Barooni Rashno

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract A pandemic of acute respiratory disease referred to as COVID-19 has been caused by the highly infectious and transmissible Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which threatened human health. Although SARS-CoV-2 RNA found in wastewater from numerous regions different countries due fecal shedding infected individuals, there is still little information available regarding how prevalent it other water matrices especially groundwater, where some areas rely on supply drinking water, irrigation farmlands, purposes. This study attempted assess presence this virus genome groundwater samples Tehran, Iran. These were collected seasonally 12 sites over years period (2021–2023). At first, a adsorption-elution (VIRADEL) concentration procedure was tested utilizing an avian coronavirus (infectious bronchitis virus, IBV) process control followed extraction. Subsequently, quantified using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) detect E S genes. As result, detected 1 out 96 with 2/53 × 103 3/16 copies/l for genes, respectively. Furthermore, positive sample subjected semi-nested PCR targeting partial gene, direct sequencing, phylogenetic mutation analysis. BA.1 Omicron only identified variant during study. findings show important water-based epidemiology monitor at community-level subsequent exposure, even when prevalence low.

Language: Английский

Citations

0