Anticancer Drugs: Recent Strategies to Improve Stability Profile, Pharmacokinetic and Pharmacodynamic Properties

Molecules, Journal Year: 2022, Volume and Issue: 27(17), P. 5436 - 5436

Published: Aug. 25, 2022

In past decades, anticancer research has led to remarkable results despite many of the approved drugs still being characterized by high systemic toxicity mainly due lack tumor selectivity and present pharmacokinetic drawbacks, including low water solubility, that negatively affect drug circulation time bioavailability. The stability studies, performed in mild conditions during their development or under stressing exposure temperature, hydrolytic medium light source, have demonstrated sensitivity parameters. For this reason, formation degradation products is assessed both pharmaceutical formulations environment as hospital waste. To date, numerous been developed for achieving tissue-specific targeting reducing toxic side effects, well improving stability. prodrugs represents a promising strategy targeted cancer therapy selectivity, efficacy active compounds. Recent studies show incorporation into vesicular systems, such polymeric micelles cyclodextrins, use nanocarriers containing chemotherapeutics conjugate monoclonal antibodies can improve pharmacokinetics, cellular absorption study, we summarize latest advances knowledge regarding effective highly stable formulated entrapped nanosystems.

Language: Английский

---

Functionalized liposomes for targeted breast cancer drug delivery

Bioactive Materials, Journal Year: 2023, Volume and Issue: 24, P. 401 - 437

Published: Jan. 2, 2023

Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and treatment strategies, it remains a prominent cause of female mortality worldwide. Additionally, although chemotherapies are effective, they associated with critical limitations, most notably their lack specificity resulting systemic toxicity eventual development multi-drug resistance (MDR) cells. Liposomes have proven to be an invaluable drug delivery system but multitudes liposomal systems developed every year only few been approved for clinical use, none which employ active targeting. In this review, we summarize recent strategies actively targeted surface, transmembrane internal cell receptors, enzymes, direct targeting dual-targeting cancer-associated cells, e.g., stem cells tumor microenvironment, etc.

Language: Английский

---

Carboxymethyl cellulose/starch/reduced graphene oxide composite as a pH-sensitive nanocarrier for curcumin drug delivery

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 241, P. 124566 - 124566

Published: April 24, 2023

Language: Английский

---

A self-assembly nano-prodrug for triple-negative breast cancer combined treatment by ferroptosis therapy and chemotherapy

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 159, P. 275 - 288

Published: Jan. 26, 2023

Language: Английский

---

An electrochemical sensor based on a modified glassy carbon electrode for detection of epinephrine in the presence of theophylline

ADMET & DMPK, Journal Year: 2024, Volume and Issue: 12(2), P. 391 - 402

Published: April 17, 2024

Neurotransmitters are chemical messengers that enhance and balance signals between cells target in the body. They vital to body's ability function. Epinephrine is one of most essential catecholamine neurotransmitters with an important biological pharmacological role mammalian central nervous system. Therefore, it very develop sensitive, simple, fast methods for determination this compound.

Language: Английский

---

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

Polymers, Journal Year: 2020, Volume and Issue: 12(7), P. 1519 - 1519

Published: July 8, 2020

Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the deacetylation of chitin. CS non-toxic, highly biocompatible, and biodegradable, it has low immunogenicity. Additionally, inherent antibacterial properties mucoadhesive character can disrupt epithelial tight junctions, thus acting as permeability enhancer. As such, its derivatives are well-suited for challenging field ocular drug delivery. In present review article, we will discuss that contribute to successful application in delivery before reviewing latest advances use development novel ophthalmic systems. Colloidal nanocarriers (nanoparticles, micelles, liposomes) be presented, followed gels lenses inserts. Finally, instances coatings, aiming at conferring mucoadhesiveness other matrixes, presented.

Language: Английский

---

Folic acid-functionalized niosomal nanoparticles for selective dual-drug delivery into breast cancer cells: An in-vitro investigation

Advanced Powder Technology, Journal Year: 2020, Volume and Issue: 31(9), P. 4064 - 4071

Published: Sept. 1, 2020

Language: Английский

---

The influence of nanoparticulate drug delivery systems in drug therapy

Journal of Drug Delivery Science and Technology, Journal Year: 2020, Volume and Issue: 60, P. 101961 - 101961

Published: Aug. 18, 2020

Language: Английский

---

Lipid nanovesicles for biomedical applications: ‘What is in a name’?

Progress in Lipid Research, Journal Year: 2021, Volume and Issue: 82, P. 101096 - 101096

Published: April 1, 2021

Language: Английский

---

Polymeric micelles: A novel drug delivery system for the treatment of breast cancer

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 77, P. 103886 - 103886

Published: Oct. 13, 2022

Language: Английский

---