Innovative Polymer Modifications: Unlocking New Horizons in Drug Delivery Applications DOI

M. Jyothika,

Sanketh R. Gowda,

G. B. Kiran Kumar

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The chemical modification of polymers is essential for enhancing their properties and broadening applications, particularly in drug delivery systems. This study aims to provide a comprehensive overview polymer by exploring various techniques surface, bulk, post-synthetic changes. A literature review analysis existing methodologies reveal how these modifications influence industrial, biomedical, environmental with specific focus on tissue engineering. Key findings demonstrate significant improvements encapsulation efficiency, controlled release kinetics, biocompatibility, statistical analyses confirming enhancements. Despite advancements, challenges such as high production costs, impacts, stability issues persist. concludes outlining future directions research, emphasizing the importance innovative methods, advanced techniques, creation sustainable address limitations enhance performance field.

Language: Английский

“Polymer blends innovation: Advancement in novel drug delivery” DOI

Pratiksha Bramhe,

Suchita Waghmare, Nilesh Rarokar

et al.

International Journal of Polymeric Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: Aug. 7, 2024

The integration of polymers and modified in diverse drug delivery systems, including implants, gene delivery, nano-based approaches, has significantly advanced therapeutic interventions. Implants-based utilizing bio-degradable like poly(lactic-co-glycolic acid)(PLGA) polycaprolactone(PCL), demonstrates efficacy sustained release, enhancing patient compliance. Polymers synergize with efficiently targeting genetic material overcoming therapy challenges. In polymer-based nanoparticles (micelles, dendrimers, nanogels) provide precise control over release kinetics, improved uptake, enhanced bioavailability. This review underscores polymers' pivotal role developing improving efficacy, reducing systemic toxicity.

Language: Английский

Citations

1

Sustainable antimicrobial functionalization of cotton with lavender oil and jackfruit latex DOI
Gazi Farhan Ishraque Toki, Rezaul Karim Khan Alave,

Syeda Fariha Jannat Duti

et al.

Surface Innovations, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Aug. 20, 2024

In recent years, functional antimicrobial fabric materials have been in high demand the health sector due to impact of COVID-19. Considering increasing demand, availability natural, environmentally friendly, and non-toxic products is limited. this study, a facile, eco-friendly method for preparation cotton proposed. At first, scoured bleached treated with chitosan, followed by encapsulation lavender essential oil (LEO) addition Artocarpus heterophyllus Lam. (jackfruit) latex gum as binder. For optimization LEO jackfruit (JLG) performance, four variations these material’s quantity were utilized. Among all studied samples, we found that most efficient inhibition bacterial growth was induced both gram-negative (Escherichia coli) gram-positive (Staphylococcus aureus) cultures. chitosan-treated JLG added, named TG-5 (refers 3 mL 5 mL), showed impactful bacteria reduction. It demonstrates effective antibacterial reduction 92.5% 56.8% E. coli S. aureus bacterium cultures, respectively. The field emission scanning electron microscope illustrates validates morphology prepared while Fourier transform infrared employed identify chemical bonding compounds functionalized materials. Therefore, new combination an finishing agent can be replacement synthetic chemicals functionalization medical textiles.

Language: Английский

Citations

1

Optimization of solvent system for chitosan/polylactic acid/nanocellulose nanofibers using needleless electrospinning DOI
Murtaza Syed, Md. Maksudur Rahman Khan, Mior Ahmad Khushairi Mohd Zahari

et al.

Journal of Applied Polymer Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Abstract Needless electrospinning (NES) is the most advanced and robust method to generate biopolymeric nanofibers. NES overcomes needle clogging low throughput issues of conventional based (ES). However, issue with all ES techniques absence generalized methods in literature, work being done empirically. The solvent system dictates feasibility process, studies can help create more methods. current provides a systematic approach fabricating tribiopolymeric was used fabricate chitosan (CS)/polylactic acid (PLA)/nanocellulose (NCC) nanofibers by optimizing using dichloromethane (DCM) trifluoroacetic (TFA). Biopolymeric blend PLA/CS/NCC (10:0.1:0.05 w/v %) various formulated systems were made analyzed for their physical properties (sedimentation rate, particle size, viscosity, surface tension) subjected NES. binary SS91 (DCM (90):TFA (10) showed lowest sedimentation rate viscosity while highest size tension, resulting beads free tension comparison determine critical point nanofiber fabrication. Overall, study complex tri‐biopolymeric future.

Language: Английский

Citations

1

Advances in drug delivery systems utilizing blood cells and their membrane-derived microvesicles DOI Creative Commons
Andong He, Yuye Huang, Chao Cao

et al.

Drug Delivery, Journal Year: 2024, Volume and Issue: 31(1)

Published: Nov. 8, 2024

The advancement of drug delivery systems (DDSs) in recent decades has demonstrated significant potential enhancing the efficacy pharmacological agents. Despite approval certain DDSs for clinical use, challenges such as rapid clearance from circulation, toxic accumulation body, and ineffective targeted persist obstacles to successful application. Blood cell-based have emerged a popular strategy administration, offering enhanced biocompatibility, stability, prolonged circulation. These are well-suited systemic played crucial role formulating optimal combinations treating variety diseases both preclinical studies trials. This review focuses on advancements applications utilizing blood cells their membrane-derived microvesicles. It addresses current therapeutic at organ tissue levels, highlighting deployment cellular level. Furthermore, it explores mechanisms uptake vectors subcellular Additionally, discusses opportunities associated with these DDSs.

Language: Английский

Citations

1

Innovative Polymer Modifications: Unlocking New Horizons in Drug Delivery Applications DOI

M. Jyothika,

Sanketh R. Gowda,

G. B. Kiran Kumar

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The chemical modification of polymers is essential for enhancing their properties and broadening applications, particularly in drug delivery systems. This study aims to provide a comprehensive overview polymer by exploring various techniques surface, bulk, post-synthetic changes. A literature review analysis existing methodologies reveal how these modifications influence industrial, biomedical, environmental with specific focus on tissue engineering. Key findings demonstrate significant improvements encapsulation efficiency, controlled release kinetics, biocompatibility, statistical analyses confirming enhancements. Despite advancements, challenges such as high production costs, impacts, stability issues persist. concludes outlining future directions research, emphasizing the importance innovative methods, advanced techniques, creation sustainable address limitations enhance performance field.

Language: Английский

Citations

1