AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(6)
Published: Aug. 2, 2024
Language: Английский
JCIS Open, Journal Year: 2023, Volume and Issue: 12, P. 100095 - 100095
Published: Sept. 29, 2023
The lung is an attractive target for drug delivery because of the ease non-invasive administration via inhalation, bypassing metabolism in liver, direct to respiratory system treatment diseases, and a large surface area absorption. Nanocarrier systems offer several benefits pulmonary delivery, including uniform distribution among alveoli, improved solubility, sustained release, which reduces dosing frequency enhances patient compliance, potential cell internalization. Nanomedicine also being utilized combat emerging infectious illnesses like SARS-CoV, SARS-CoV-2, MERS-CoV, influenza A/H1N1. This review gives quick rundown diseases caused by agents such as bacterial, viral, biological roadblocks that prevent effective recalcitrant tract infections. We emphasized summarized recent efforts these infections using novel inhaled formulation-mediated strategies nanocarriers liposomes, polymeric nanoparticles, SLNs. In addition, we reviewed latest findings advancements regarding development inhalable formulations circumvent barriers boost bioavailability.
Language: Английский
Citations
55
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)
Published: Nov. 16, 2023
Lung cancer is the second most prevalent and leading cause of cancer-related death worldwide. Surgery, chemotherapy, molecular targeted therapy, immunotherapy, radiotherapy are currently available as treatment methods. However, drug resistance a significant factor in failure lung treatments. Novel therapeutics have been exploited to address complicated mechanisms advancement nanomedicine extremely promising terms overcoming resistance. Nanomedicine equipped with multifunctional tunable physiochemical properties alignment tumor genetic profiles can achieve precise, safe, effective while minimizing or eradicating cancer. Here, this work reviews discovered for radiotherapy, outlines novel strategies development against This focuses on engineering design, customized delivery, current challenges, clinical translation application resistant
Language: Английский
Citations
36
Polymers, Journal Year: 2023, Volume and Issue: 15(18), P. 3849 - 3849
Published: Sept. 21, 2023
The evolution of respiratory diseases represents a considerable public health challenge, as they are among the leading causes death worldwide. In this sense, in addition to high prevalence such asthma, chronic obstructive pulmonary disease, pneumonia, cystic fibrosis, and lung cancer, emerging diseases, particularly those caused by members coronavirus family, have contributed significant number deaths on global scale over last two decades. Therefore, several studies been conducted optimize efficacy treatments against these focusing drug delivery using nanomedicine. Thus, development nanocarriers has emerged promising alternative overcome limitations conventional therapy, increasing bioavailability at target site reducing unwanted side effects. context, nanoparticles composed chitosan (CS) show advantages other because possesses intrinsic biological properties, anti-inflammatory, antimicrobial, mucoadhesive capacity. Moreover, CS potential enhance stability, prolong duration action, improve targeting, control release, dissolution poorly soluble drugs, increase cell membrane permeability hydrophobic drugs. These properties could performance after its administration. review aims discuss for delivery, highlighting how their can treatment including synergistic action with encapsulated drug.
Language: Английский
Citations
24
Drying Technology, Journal Year: 2024, Volume and Issue: 42(9), P. 1415 - 1441
Published: June 2, 2024
Language: Английский
Citations
12
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 92, P. 105381 - 105381
Published: Jan. 20, 2024
Language: Английский
Citations
9
Drying Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 37
Published: Jan. 27, 2025
Language: Английский
Citations
1
Biomaterials Advances, Journal Year: 2023, Volume and Issue: 154, P. 213594 - 213594
Published: Aug. 21, 2023
Language: Английский
Citations
19
Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 170, P. 107948 - 107948
Published: Jan. 2, 2024
A well-corroborated numerical methodology ensuring reproducibility in the modeling of pharmaceutical aerosols deposition respiratory system via CFD-DEM simulations within RANS framework is currently missing. Often, inadequately clarified assumptions and approximations lack evidences on their quantitative impact simulated phenomenology, make a direct comparison among different theoretical studies limited number experiments very challenging task. Here, with ultimate goal providing critical analysis some crucial computational aspects deposition, we address issues velocity fluctuations propagation upper intra-thoracic airways persistence secondary flows using SimInhale reference benchmark. We complement investigation by describing how methodologies used to drive flow through truncated lung model may affect results small discrepancies are observed profiles when comparing based meshing strategies.
Language: Английский
Citations
8
ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(8), P. 2567 - 2583
Published: July 22, 2024
(Mtb) has long posed a significant challenge to global public health, resulting in approximately 1.6 million deaths annually. Pulmonary tuberculosis (TB) instigated by Mtb is characterized extensive lung tissue damage, leading lesions and dissemination within the matrix. Matrix metalloproteinases (MMPs) exhibit endopeptidase activity, contributing inflammatory damage and, consequently, morbidity mortality TB patients. MMP activities are intricately regulated various components, including cytokines, chemokines, cell receptors, growth factors, through intracellular signaling pathways. Primarily, Mtb-infected macrophages induce expression, disrupting balance between MMPs inhibitors of (TIMPs), thereby impairing extracellular matrix (ECM) deposition lungs. Recent research underscores significance immunomodulatory factors secretion granuloma formation during pathogenesis. Several studies have investigated both activation inhibition using endogenous (i.e., TIMPs) synthetic inhibitors. However, despite their promising pharmacological potential, few been explored for treatment as host-directed therapy. Scientists exploring novel strategies enhance therapeutic regimens suppressing activity mitigate Mtb-associated destruction reduce induced inflammation. These include use inhibitor molecules alone or combination with anti-TB drugs. Additionally, there growing interest developing formulations containing MMP-responsive drug delivery systems suppress release drugs at specific target sites. This review summarizes MMPs' expression regulation TB, role immune response, potential effective targets alleviate immunopathology.
Language: Английский
Citations
7
Nanoscale, Journal Year: 2024, Volume and Issue: 16(35), P. 16485 - 16499
Published: Jan. 1, 2024
Enhanced treatment for CNS-TB: Intranasal chitosan nano-aggregates with Anti-TB drugs overcome the blood–brain barrier and reduce mycobacterial load.
Language: Английский
Citations
6