Archiv Euromedica,
Journal Year:
2023,
Volume and Issue:
13(6)
Published: Dec. 27, 2023
Purpose
of
the
Study:
To
analyze
effectiveness
using
sodium
deoxyribonucleate
(SDN)
for
pelvic
adhesions
in
rats
experiment.
Materials
and
Methods:
The
experiment
was
carried
out
on
90
laboratory
rats.
Three
groups
30
animals
each
were
formed:
group
1
–
control;
2
with
a
simulated
adhesive
process
pelvis
without
subsequent
treatment;
3
model
receiving
intramuscular
SDN
10
days.
modeled
by
ligating
uterine
horns
both
sides.
expression
CD4,
CD8,
CD20,
CD138
studied
DP-SOFT
software
program
statistical
processing.
Results:
In
control
group,
small
number
cells
CD4+,
CD8+
markers
found
parietal
peritoneum
(PP).
perimetrium
(PM),
no
positively
stained
immunophenotype
found.
2,
showed
an
increase
PP
expressing
CD4+
CD138+,
appearance
CD56+
cells.
An
CD138+
rats’
PM.
3,
compared
to
control,
count
cells,
significantly
increased.
PM
operated
animals,
we
rats,
noted,
which
indicates
activation
humoral
immune
system.
increased
control.
characterized
similar
distribution
Conclusion:
After
surgery,
causes
change
ratio
leukocyte
subpopulations
affected
area
towards
their
rather
than
perimetrium.
use
has
immunomodulatory
effect
stimulates
responses
increasing
immunocompetent
surgical
site.
Journal of Bioactive and Compatible Polymers,
Journal Year:
2023,
Volume and Issue:
39(1), P. 63 - 75
Published: Dec. 8, 2023
Abdominal
adhesions
are
still
among
the
most
common
postsurgical
peritoneal
inflammation-related
complications.
Adhesion-related
disorders
highly
costly
and
prevalent
due
to
advances
in
surgical
techniques,
treatment
methods,
various
drugs.
The
present
study
aimed
investigate
effects
of
Poly
(
D,L-lactide-co-glycolide)
(PLGA)-
polyethylene
glycol
(PEG6000)
Nanofiber
+
Melatonin
on
abdominal
adhesion
model
rats.
For
this
purpose,
PLGA-PEG6000
matrix
was
fabricated
implanted
an
experimental
Our
consisted
vitro
vivo
part.
degradation
release
profile
(Mel)
embedded
performed
vitro.
In
vivo,
procedure
carried
out
with
18
Wistar
male
Rats
were
divided
into
three
groups
as
follows:
Sham,
Matrix,
Mel
respectively.
Consequent
profiling
vitro,
created
pure
(2
×
2
cm
),
,
0.25
mg
melatonin/per
embedded)
applied
injury
area
related
groups.
Intra-abdominal
scores
determined
post-op
21st
day,
under
general
anesthesia.
Following,
cecum,
tissue,
adhesive
bands
harvested.
Macroscopic
analysis
(severity
formation),
Hematoxlyn&Eosin
Masson’s
Trichrome
staining
(for
examination
levels
infiltration
inflammatory
cells,
fibrosis,
neovascularization)
for
evaluation
results
indicated
that
degraded
completely
rats
cavity
significantly
reduced
formation
compared
other
macroscopically
p
<
0.05).
On
hand,
histopathological
cell
infiltration,
neovascularization
levels.
Archiv Euromedica,
Journal Year:
2023,
Volume and Issue:
13(6)
Published: Dec. 27, 2023
Purpose
of
the
Study:
To
analyze
effectiveness
using
sodium
deoxyribonucleate
(SDN)
for
pelvic
adhesions
in
rats
experiment.
Materials
and
Methods:
The
experiment
was
carried
out
on
90
laboratory
rats.
Three
groups
30
animals
each
were
formed:
group
1
–
control;
2
with
a
simulated
adhesive
process
pelvis
without
subsequent
treatment;
3
model
receiving
intramuscular
SDN
10
days.
modeled
by
ligating
uterine
horns
both
sides.
expression
CD4,
CD8,
CD20,
CD138
studied
DP-SOFT
software
program
statistical
processing.
Results:
In
control
group,
small
number
cells
CD4+,
CD8+
markers
found
parietal
peritoneum
(PP).
perimetrium
(PM),
no
positively
stained
immunophenotype
found.
2,
showed
an
increase
PP
expressing
CD4+
CD138+,
appearance
CD56+
cells.
An
CD138+
rats’
PM.
3,
compared
to
control,
count
cells,
significantly
increased.
PM
operated
animals,
we
rats,
noted,
which
indicates
activation
humoral
immune
system.
increased
control.
characterized
similar
distribution
Conclusion:
After
surgery,
causes
change
ratio
leukocyte
subpopulations
affected
area
towards
their
rather
than
perimetrium.
use
has
immunomodulatory
effect
stimulates
responses
increasing
immunocompetent
surgical
site.
