BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 2, 2024
Language: Английский
Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)
Published: Oct. 4, 2024
Nanomedicine has the potential to transform healthcare by offering targeted therapies, precise diagnostics, and enhanced drug delivery systems. The National Institutes of Health coined term "nanomedicine" describe use nanotechnology in biological system monitoring, control, diagnosis, treatment. continues receive increasing interest for rationalized therapeutics pharmaceutical agents achieve required response while reducing its side effects. However, as advance, concerns about toxicological effects have also grown. This review explores current state nanomedicine, focusing on types nanoparticles used their associated properties that contribute nanotoxicity. It examines mechanisms through which exert toxicity, encompassing various cellular molecular interactions. Furthermore, it discusses assessment methods employed evaluate nanotoxicity, in-vitro in-vivo models, well emerging techniques. addresses regulatory issues surrounding nanotoxicology, highlighting challenges developing standardized guidelines ensuring secure translation nanomedicine into clinical settings. ethical with understanding safety profile is essential effective therapeutic applications.
Language: Английский
Citations
13
Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: unknown
Published: July 27, 2024
Language: Английский
Citations
9
Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 16, 2025
Abstract Phytonanoparticles have emerged as a promising class of biomaterials for enhancing bone regeneration and osseointegration, offering unique advantages in biocompatibility, multifunctionality, sustainability. This comprehensive review explores the synthesis, characterization, applications phytonanoparticles tissue engineering. The green synthesis approach, utilizing plant extracts reducing stabilizing agents, yields nanoparticles with intrinsic bioactive properties that can synergistically promote osteogenesis. We examine mechanisms by which phytonanoparticles, particularly those derived from gold, silver, zinc oxide, influence key molecular pathways osteogenesis, including RUNX2 Osterix signaling. discusses advanced strategies phyto-nanoparticle design, such surface functionalization stimuli-responsive release mechanisms, enhance their efficacy applications. Preclinical studies demonstrating improved osteoblast proliferation, differentiation, mineralization are critically analyzed, along emerging clinical data. Despite results, scalability, standardization, regulatory approval challenges persist. also addresses economic environmental implications production. Looking ahead, we identify research directions, developing personalized therapies, combination approaches stem cells or gene delivery, long-term safety assessments. By harnessing power plant-derived nanomaterials, represent an innovative approach to addressing complex regeneration, potential spanning dental, orthopedic, maxillofacial surgery. Graphical abstract
Language: Английский
Citations
1
Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2024, Volume and Issue: 1868(3), P. 130559 - 130559
Published: Jan. 6, 2024
Language: Английский
Citations
7
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: Dec. 12, 2024
Mortality and morbidity from cardiovascular diseases are common worldwide. In order to improve survival quality of life for this patient population, extensive efforts being made establish effective therapeutic modalities. New treatment options needed, it seems. addition treating diseases, cell therapy is one the most promising medical platforms. One approaches in area stem therapy. biology, multipotent cells pluripotent divided into two types. There evidence that could be used as a approach based on multiple lines evidence. The effectiveness therapies humans has been studied several clinical trials. spite challenges associated with therapy, appears resolving them may lead disease patients. This an approach. By mounting these biological scaffolds, their effect can enhanced.
Language: Английский
Citations
7
Journal of Biophotonics, Journal Year: 2024, Volume and Issue: 17(1)
Published: Jan. 1, 2024
Regenerative medicine, which utilizes stem cells for tissue and organ repair, holds immense promise in healthcare. A comprehensive understanding of cell characteristics is crucial to unlock their potential. This study explores the pivotal role optical microscopy advancing regenerative medicine as a potent tool research. Advanced techniques enable an in-depth examination behavior, morphology, functionality. The review encompasses current microscopy, elucidating its capabilities constraints imaging, while also shedding light on emerging technologies improved visualization. Optical complemented by like fluorescence multiphoton enhances our comprehension dynamics. introduction label-free imaging facilitates noninvasive, real-time monitoring without external dyes or markers. By pushing boundaries researchers reveal intricate cellular mechanisms underpinning processes, thereby more effective therapeutic strategies. not only outlines future but underscores both structural functional imaging.
Language: Английский
Citations
5
Life Sciences, Journal Year: 2024, Volume and Issue: 350, P. 122747 - 122747
Published: May 24, 2024
Language: Английский
Citations
4
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117372 - 117372
Published: Aug. 28, 2024
Polymeric nanoparticles have emerged as promising contenders for addressing the intricate challenges encountered in brain tumor therapy due to their distinctive attributes, including adjustable size, biocompatibility, and controlled drug release kinetics. This review comprehensively delves into latest developments synthesizing, characterizing, applying polymeric explicitly tailored therapy. Various synthesis methodologies, such emulsion polymerization, nanoprecipitation, template-assisted fabrication, are scrutinized within context of targeting, elucidating advantages limitations concerning traversing blood-brain barrier. Furthermore, strategies pertaining surface modification functionalization expounded upon augment stability, targeting prowess amidst milieu microenvironment. Characterization techniques encompassing dynamic light scattering, transmission electron microscopy, spectroscopic methods evaluate physicochemical attributes engineered Moreover, a comprehensive exploration manifold applications delivery, gene therapy, imaging, combination therapies tumours is undertaken. Special emphasis placed on encapsulation diverse therapeutics nanoparticles, thereby shielding them from degradation enabling precise brain. Additionally, recent advancements stimuli-responsive multifunctional probed potential personalized medicine theranostics tumours. In essence, this furnishes an all-encompassing overview strides made tailoring illuminating synthesis, characterization, multifaceted application.
Language: Английский
Citations
4
Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 30, 2024
Abstract The incidence of nerve tissue injuries, such as peripheral injury, spinal cord traumatic brain and various neurodegenerative diseases (NDs), is continuously increasing because stress, physical chemical trauma, the aging population worldwide. Restoration damaged nervous system challenging its structural functional complexity limited regenerative ability. Additionally, there no cure available for NDs except medications that provide symptomatic relief. Stem cells offer an alternative approach promoting damage repair, but their efficacy by a compromised survival rate neurogenesis process. To address these challenges, neural engineering has emerged promising strategy in which stem are seeded or encapsulated within suitable biomaterial construct, cell neurogenesis. Numerous biomaterials utilized to create different types constructs this purpose. Researchers trying develop ideal scaffolds combine biomaterials, cells, molecules exactly mimic biological mechanical properties achieve recovery associated with neurological dysfunction. This review focuses on exploring development applications potential use diagnosis, therapy, regeneration, treatment disorders.
Language: Английский
Citations
4
Neuroscience, Journal Year: 2024, Volume and Issue: 565, P. 63 - 79
Published: Nov. 26, 2024
Language: Английский
Citations
4