Nanoscale Advances,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
Liposomes
are
employed
for
the
delivery
of
molecular
cargo
in
several
classes
systems.
For
instance,
embedding
loaded
liposomes
polymeric
fibrous
scaffolds
has
enabled
creation
hybrid
materials
that
mimic
biological
membranes.
with
unmodified
surfaces
have
been
predominantly
integrated
into
fibers,
which
leads
to
instabilities
due
interfacial
incompatibility.
In
addition,
electrospinning
almost
exclusively
fiber
fabrication,
limits
potential
scale-up
production.
Here,
we
present
fabrication
biomimetic
by
fusing
polymer-coated
force-spun
microfibers
increase
stability
and
enhance
sustained
release
cargo.
l-α-Phosphatidylcholine
were
coated
chitosan
or
polyethylene
glycol
(PEG).
The
nano-differential
scanning
calorimetry
results
confirm
polymer
coating
does
not
affect
phase
transition
temperature
(T
m)
liposomes,
where
only
model
drug,
quercetin,
reduced
T
m.
Centrifugal
spinning
was
fabricate
hydrophobic
polycaprolactone
(PCL)
at
various
concentrations
using
solvents
parameters
yield
lowest
diameter.
highest
microfiber
production
rate
obtained
occurred
a
20%
(w/v)
PCL
concentration
50
:
(v/v)
chloroform
methanol
solution
an
average
diameter
584.85
±
26.30
nm.
non-chemical
fusion
promoted
immersion
>
m,
under
ultrasonication.
We
hypothesize
is
driven
interactions
between
merge
through
lipid
bilayer.
fused
material
solved
burst
problem
observed
when
adhering
plain
nanofibers.
Both
PEG
yielded
release,
former
faster.
These
demonstrate
enables
more
effective
blending
carriers
microfibers.
Ultimately,
liposome/microfiber
hybrids
stable
matrices
Journal of Clinical and Pharmaceutical Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 13, 2024
In
recent
years,
the
field
of
drug
delivery
has
undergone
a
transformative
shift
with
introduction
innovative
platforms
that
transcend
conventional
methods,
providing
accurate
and
efficient
means
for
delivering
therapeutic
agents.
This
exploration
delves
into
distinctive
features
potential
impacts
these
pioneering
platforms,
charting
course
future
pharmaceutical
interventions.
this
review
article,
advancements
regarding
nanotechnology-enabled
delivery,
lipid-based
systems,
targeted
implantable
3D
printing
in
stimuli-responsive
mRNA
gene
microfluidic
-
based
systems
were
discussed.
These
represent
dynamic
frontier
research
development.
They
afford
unprecedented
control
over
properties,
release
kinetics
targeting
strategies.
As
continues
to
push
boundaries
science,
innovations
hold
revolutionize
treatment
various
diseases,
ushering
safer,
more
effective
patient-centric
solutions.
Nanoscale Advances,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
Liposomes
are
employed
for
the
delivery
of
molecular
cargo
in
several
classes
systems.
For
instance,
embedding
loaded
liposomes
polymeric
fibrous
scaffolds
has
enabled
creation
hybrid
materials
that
mimic
biological
membranes.
with
unmodified
surfaces
have
been
predominantly
integrated
into
fibers,
which
leads
to
instabilities
due
interfacial
incompatibility.
In
addition,
electrospinning
almost
exclusively
fiber
fabrication,
limits
potential
scale-up
production.
Here,
we
present
fabrication
biomimetic
by
fusing
polymer-coated
force-spun
microfibers
increase
stability
and
enhance
sustained
release
cargo.
l-α-Phosphatidylcholine
were
coated
chitosan
or
polyethylene
glycol
(PEG).
The
nano-differential
scanning
calorimetry
results
confirm
polymer
coating
does
not
affect
phase
transition
temperature
(T
m)
liposomes,
where
only
model
drug,
quercetin,
reduced
T
m.
Centrifugal
spinning
was
fabricate
hydrophobic
polycaprolactone
(PCL)
at
various
concentrations
using
solvents
parameters
yield
lowest
diameter.
highest
microfiber
production
rate
obtained
occurred
a
20%
(w/v)
PCL
concentration
50
:
(v/v)
chloroform
methanol
solution
an
average
diameter
584.85
±
26.30
nm.
non-chemical
fusion
promoted
immersion
>
m,
under
ultrasonication.
We
hypothesize
is
driven
interactions
between
merge
through
lipid
bilayer.
fused
material
solved
burst
problem
observed
when
adhering
plain
nanofibers.
Both
PEG
yielded
release,
former
faster.
These
demonstrate
enables
more
effective
blending
carriers
microfibers.
Ultimately,
liposome/microfiber
hybrids
stable
matrices
