Establishment and Evaluation of Paclitaxel and Simvastatin-Laden Nanofibers for Post-surgical Tumor Recurrence in Breast Cancer DOI

Paras Famta,

Saurabh Shah,

Ganesh Vambhurkar

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(3)

Published: May 21, 2025

Language: Английский

Docetaxel and niclosamide-loaded nanofiber systems for improved chemo-therapeutic activity and resistance reversal in prostate cancer DOI
Saurabh Shah,

Paras Famta,

Ganesh Vambhurkar

et al.

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 16, 2025

The objective of the study was to tackle recurrence prostate cancer (PCa) post-surgery and re-sensitize docetaxel (DTX)-resistant PC-3 cells chemo-therapy using NIC. Prolonged DTX therapy leads emergence chemo-resistance by overexpression PI3K-AKT pathway in PCa along with tumor post-surgery. Suppression this could be essential improving anticancer activity re-sensitizing resistant cells. Niclosamide (NIC), an anthelmintic drug has shown tremendous potential re-sensitized various drugs. To mitigate post-surgical recurrence, implant-based system facilitating sustained release NIC beneficial. were incorporated within a nanofiber (NF) prevent on-site local DTX-resistant fabricated DTX-NIC NF via electrospinning 334 ± 96.14 nm diameter demonstrated profile till 6 d. Elevated mitochondrial damage, reactive oxygen species levels apoptotic index revealed improvement cytotoxicity post incorporation into owing their profile. Re-sensitization PC-3/DTX observed introduction which due suppression p-Akt1, overexpressed From superior re-sensitization cells, we conclude that beneficial therapeutic regimen preventing PCa.

Language: Английский

Citations

8
QbD Manoeuvred Niclosamide Laden Polylactic-co-Glycolic Acid Nanoparticles-Impregnated Gelatin Nanofibers for the Management of Oral Carcinoma DOI
Saurabh Shah,

Paras Famta,

Rahul Kumar

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 5, 2025

Language: Английский

Citations

7
Harnessing Electrospun Nanofibers for Comprehensive Oral Disease Management: Current Trends and Future Perspectives DOI

R.S. Gupta,

Giriraj Pandey,

Ajay Kumar

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106681 - 106681

Published: Feb. 7, 2025

Language: Английский

Citations

4
Exploring advancements in polysaccharide-based approaches: The cornerstone of next-generation cartilage regeneration therapeutics DOI
Noella Abraham,

Giriraj Pandey,

Tejaswini Kolipaka

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141352 - 141352

Published: Feb. 1, 2025

Language: Английский

Citations

2
Nanotechnology invigorated drug delivery and tissue engineering strategies for the management of diabetic foot ulcers: Therapeutic approaches and clinical applications DOI

Giriraj Pandey,

Tejaswini Kolipaka,

Dadi A. Srinivasarao

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105665 - 105665

Published: April 16, 2024

Language: Английский

Citations

8
Exploration of Multi-layered Nanofiber Adjuvant Implants of Doxorubicin and Resveratrol to Prevent Post-Surgery Tumor Recurrence and Invasion DOI

Paras Famta,

Saurabh Shah,

Anamika Sharma

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105977 - 105977

Published: July 14, 2024

Language: Английский

Citations

8
In silico and in vitro profiling of sphingomyelin loaded zein nanoconstructs with optimized aromatic interactions and pharmacokinetics for colon cancer therapeutics DOI
Amit Kumar Srivastav, Jyoti Jaiswal, Pradeep Kumar Rajput

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141845 - 141845

Published: March 1, 2025

Language: Английский

Citations

0
Navigating the Complexities of Diabetic Foot Ulcers: From Pathophysiology to Advanced Treatment Strategies DOI

Giriraj Pandey,

Tejaswini Kolipaka,

Dadi A. Srinivasarao

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106852 - 106852

Published: March 1, 2025

Language: Английский

Citations

0
Advancements in Skin Tissue Regeneration: Unveiling Emerging Treatment Strategies, Regulatory Perspectives, and Future Directions for Enhanced Healing DOI

Pawan Jaiswal,

Giriraj Pandey,

Shivam Kumar

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106872 - 106872

Published: April 1, 2025

Language: Английский

Citations

0
Metal-Organic Frameworks as Therapeutic Chameleons: Revolutionizing the Cancer Therapy Employing Novel Nanoarchitectonics DOI Creative Commons

Sajja Bhanu Prasad,

Akshay Shinde,

Dadi A. Srinivasrao

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101054 - 101054

Published: April 1, 2025

Language: Английский

Citations

0