Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122853 - 122853
Published: Sept. 27, 2024
Language: Английский
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.
Language: Английский
Citations
2
Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137260 - 137260
Published: Jan. 1, 2025
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1306 - 1306
Published: Oct. 7, 2024
Biomimetic nanoparticles (BMNPs) are innovative nanovehicles that replicate the properties of naturally occurring extracellular vesicles, facilitating highly efficient drug delivery across biological barriers to target organs and tissues while ensuring maximal biocompatibility minimal-to-no toxicity. BMNPs can be utilized for therapeutic payloads imparting novel other nanotechnologies based on organic inorganic materials. The application specifically modified membranes coating has potential enhance their efficacy biocompatibility, presenting a promising pathway advancement technologies. This manuscript is grounded in fundamentals biomimetic technologies, offering comprehensive overview analytical perspective preparation functionalization BMNPs, which include cell membrane-coated (CMCNPs), artificial cell-derived vesicles (ACDVs), fully synthetic (fSVs). review examines both "top-down" "bottom-up" approaches nanoparticle preparation, with particular focus techniques such as membrane coating, cargo loading, microfluidic fabrication. Additionally, it addresses technological challenges solutions associated large-scale production clinical related
Language: Английский
Citations
4
Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 359 - 359
Published: March 1, 2025
Modernization of existing methods for the delivery mRNA is vital in advanced therapeutics. Traditionally, has faced obstacles poor stability due to enzymatic degradation. This work examines cutting-edge formulation and emerging techniques safer vaccines. Inspired by success lipid nanoparticles (LNP) delivering vaccines COVID-19, a variety other formulations have been developed deliver diverse infections. The meritorious features nanoparticle-based strategies, including LNP, polymeric, dendrimers, polysaccharide-based, peptide-derived, carbon metal-based, DNA nanostructures, hybrid, extracellular vesicles, examined. impact these platforms on vaccine efficacy, protection from degradation, cellular uptake, controlled release, immunogenicity discussed detail. Even with significant developments, there are certain limitations overcome, toxicity concerns, limited information about immune pathways, need maintain cold chain, necessity optimizing administration methods. Continuous innovation essential improving systems Future research directions proposed address challenges expand their potential prophylactic therapeutic application.
Language: Английский
Citations
0
Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113369 - 113369
Published: March 1, 2025
Language: Английский
Citations
0
Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122853 - 122853
Published: Sept. 27, 2024
Language: Английский
Citations
0