Formulation Advances in Posterior Segment Ocular Drug Delivery

Journal of Ocular Pharmacology and Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Posterior segment ocular diseases, such as diabetic retinopathy, age-related macular degeneration, and retinal vein occlusion, are leading causes of vision impairment blindness worldwide. Effective management these conditions remains a formidable challenge due to the unique anatomical physiological barriers eye, including blood-retinal barrier rapid drug clearance mechanisms. To address hurdles, nanostructured delivery systems proposed overcome barriers, target retina, enhance permeation while ensuring controlled release. Traditional therapeutic approaches, intravitreal injections, pose significant drawbacks, patient discomfort, poor compliance, potential complications. Therefore, understanding physiology mechanism eye could aid in design novel formulations that be noninvasive deliver drugs reach site is pivotal for effective treatment strategies. This review focuses on recent advances formulation strategies posterior delivery, highlighting their limitations. Furthermore, nanocarrier in-situ gel, niosomes, hydrogels, dendrimers, liposomes, nanoparticles, nanoemulsions more effectively selectively explored, supplemented with illustrative examples, figures, tables. aims provide insights into current state emphasizing need interdisciplinary approaches develop patient-centric, minimally invasive, solutions.

Language: Английский

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Curcumin in Ophthalmology: Mechanisms, Challenges, and Emerging Opportunities

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 457 - 457

Published: Jan. 21, 2025

Ocular diseases affecting the anterior and posterior segments of eye are major causes global vision impairment. Curcumin, a natural polyphenol, exhibits anti-inflammatory, antioxidant, antibacterial, neuroprotective properties, making it promising candidate for ocular therapy. However, its clinical use is hindered by low aqueous solubility, poor bioavailability, rapid systemic elimination. This review comprehensively highlights advances in curcumin delivery systems aimed at overcoming these challenges. Emerging platforms, including proniosomal gels, transferosomes, cyclodextrin complexes, have improved permeability, retention. Nanoparticle-based carriers, such as hybrid hydrogels biodegradable nanoparticles, enable sustained release targeted delivery, supporting treatments segment like diabetic retinopathy age-related macular degeneration. For conditions, keratitis dry syndrome, cyclodextrin-based complexes mucoadhesive enhance corneal permeability drug Mechanistically, modulates key pathways, NF-κB TLR4, reducing oxidative stress, angiogenesis, apoptosis. strategies photodynamic therapy approaches broaden their application to eyelid conditions neuroinflammatory diseases. These advancements address curcumin’s pharmacokinetic limitations, translation into ophthalmic therapies. work underscores potential disease management advocates trials validate safety, efficacy, therapeutic relevance.

Language: Английский

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Synthesis and biological applications of nanocomposite hydrogels based on the methacrylation of hydroxypropyl methylcellulose and lignin loaded with alpha-pinene

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 346, P. 122642 - 122642

Published: Aug. 22, 2024

Language: Английский

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Cyclodextrin-grafted redox-responsive hydrogel mediated by disulfide bridges for regulated drug delivery

Designed Monomers & Polymers, Journal Year: 2024, Volume and Issue: 27(1), P. 21 - 34

Published: May 30, 2024

In this paper, a novel mono-methacrylated β-cyclodextrin (β-CD) monomer mediated by disulfide bond was synthesized, and then thermal copolymerized with HEMA in the presence of little crosslinker to prepare redox-responsive hydrogel for regulated drug delivery. The structure confirmed FTIR,

Language: Английский

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Advancements in hydrogel technology for ocular drug delivery

Published: Dec. 12, 2024

Hydrogel-based drug delivery systems (DDS) offer promising alternatives for treating ocular diseases by overcoming the limitations of traditional therapies, such as low bioavailability, frequent administration, and invasiveness. Hydrogels, with their high biocompatibility ability to respond external stimuli, can provide sustained targeted delivery. This review highlights unique properties hydrogels, including swelling behavior, porosity, mechanical strength, making them suitable various applications. The classification hydrogels based on cross-linking methods, origins, stimuli responsiveness is discussed, emphasizing potential in dry eye disease (DED), glaucoma, corneal alkali burns, neovascularization. Notable advances include thermosensitive pH-responsive which have shown results preclinical studies. Despite these advances, most studies are still stages, highlighting need rigorous human trials validate safety efficacy hydrogel DDS. Collaborative efforts among researchers, pharmacologists, ophthalmologists essential translating innovations into clinical practice, ultimately improving patient outcomes management.

Language: Английский

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Treatment of endophthalmitis using a novel methacrylic anhydride-modified hydroxypropyl methylcellulose hydrogels loaded with S-nitrosoglutathione: An ex-vivo keratitis model

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106113 - 106113

Published: Aug. 27, 2024

Language: Английский

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Locally Acting Budesonide-Loaded Solid Self-Microemulsifying Drug Delivery Systems (SMEDDS) for Distal Ulcerative Colitis

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 11819 - 11846

Published: Nov. 1, 2024

Budesonide (BUD) is a BCS class II medication with poor water solubility and limited oral bioavailability. In this study, innovative solid self-microemulsifying drug delivery systems (BUD-SMEDDS) were developed for effective local management of distal ulcerative colitis (UC).

Language: Английский

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