Advances in Antibiotic-Loaded Nanofibers for the Treatment of Bone Infections: A Review DOI Open Access
Teguh Imanto, Nonni Soraya Sambudi, Khadijah Zai

et al.

Pharmacon Jurnal Farmasi Indonesia, Journal Year: 2024, Volume and Issue: unknown, P. 161 - 175

Published: Dec. 31, 2024

Antibiotic-loaded nanofiber-based drug delivery systems represent a novel approach to treating complex bone infections, particularly osteomyelitis caused by antibiotic-resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA). These offer localized, sustained release, significantly reducing systemic side effects and mitigating the development of antibiotic resistance. This review evaluates advancements in electrospun nanofibers with biodegradable polymers like Poly(lactic-co-glycolic acid) (PLGA) Polycaprolactone (PCL), which ensure controlled release while supporting regeneration. A systematic search using PRISMA guidelines across ScienceDirect ACS Publication databases (2020-2024) identified 42 relevant studies. The inclusion bioactive agents hydroxyapatite was found enhance antibacterial properties accelerate tissue demonstrates that antibiotic-loaded promising, targeted therapeutic alternative conventional treatments, for similar challenging infections. Future research directions will focus on optimizing nanofiber compositions functionalities better meet clinical needs, ensuring more efficient personalized management severe

Language: Английский

Advances in Antibiotic-Loaded Nanofibers for the Treatment of Bone Infections: A Review DOI Open Access
Teguh Imanto, Nonni Soraya Sambudi, Khadijah Zai

et al.

Pharmacon Jurnal Farmasi Indonesia, Journal Year: 2024, Volume and Issue: unknown, P. 161 - 175

Published: Dec. 31, 2024

Antibiotic-loaded nanofiber-based drug delivery systems represent a novel approach to treating complex bone infections, particularly osteomyelitis caused by antibiotic-resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA). These offer localized, sustained release, significantly reducing systemic side effects and mitigating the development of antibiotic resistance. This review evaluates advancements in electrospun nanofibers with biodegradable polymers like Poly(lactic-co-glycolic acid) (PLGA) Polycaprolactone (PCL), which ensure controlled release while supporting regeneration. A systematic search using PRISMA guidelines across ScienceDirect ACS Publication databases (2020-2024) identified 42 relevant studies. The inclusion bioactive agents hydroxyapatite was found enhance antibacterial properties accelerate tissue demonstrates that antibiotic-loaded promising, targeted therapeutic alternative conventional treatments, for similar challenging infections. Future research directions will focus on optimizing nanofiber compositions functionalities better meet clinical needs, ensuring more efficient personalized management severe

Language: Английский

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