Spatially Variable Genes DOI

Shantagoud Biradar,

Chaaya Suresh,

Nagashri Nanjundeshwara

et al.

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 28

Published: Dec. 17, 2024

The clinical translation of spatial transcriptomics represents cancer diagnosis and therapy based on the role heterogeneity cancer-associated fibroblasts (CAFs) within tumor microenvironment (TME). Recent developments in have enabled a detailed characterization organization cellular interactions tumors. data integration, multi-omics approaches, along with developing standardized protocols is essential for effective translation. experimental selection regimes factorial designs reveals novel insights into biomarkers prognostic value CAFs. incorporation optogenetics advancements bio-engineered gene circuits, therapeutics tissue engineering further underscores potential to refine patient stratification improve treatment responsiveness. By integrating workflows, this work aims advance personalized therapies biology.

Language: Английский

NIR-triggered and Thermoresponsive Core-shell nanoparticles for synergistic anticancer therapy DOI
Hong Zhang, Xiao Wang, Xiaorong Yang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 374, P. 194 - 204

Published: Aug. 15, 2024

Language: Английский

Citations

5
Recent advances of hyaluronic acid‐based materials in drug delivery systems and regenerative medicine: A review DOI

Mohamed J. Saadh,

Hanan Hassan Ahmed,

Radhwan Abdul Kareem

et al.

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(3)

Published: March 1, 2025

Abstract Nowadays, diseases have a high rate of incidence and mortality worldwide. On the other side, drawbacks conventional modalities in suppression encountered serious problematic issues for health human beings. For instance, although various approaches been applied treatment cancer, it has an ever‐increasing throughout globe. Thus, there is fundamental requirement development breakthrough technologies inhibition diseases. Hyaluronic acid (HA) one most practical biopolymers HA lots potential physicochemical (like rheological, structural, molecular weight, ionization, etc.) biomedical properties (bioavailability, biocompatibility, CD44 targeting signaling pathways, components biological organs, mucoadhesion, immunomodulation, etc.), which made candidate tools pharmaceutical sciences. The ease surface modification (carboxylation, amidation, hydroxylation, esterification), bioavailability synthesis routes, administration routes are considered as merits HA‐based vehicles. These mucopolysaccharide materials considerably developed use drug delivery systems (DDSs), cancer therapy, wound healing, antiaging, tissue engineering. This review summarizes advantages DDS scaffolds

Language: Английский

Citations

0
Emerging trends of mesoporous silica nanoparticles in colon targeting DOI

Lajja Patel,

Shailvi Shah,

Shreyansh Chauhan

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 395 - 421

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nanoarchitectonics for Biomedical Research: Post‐Nanotechnology Materials Approach for Bio‐Active Application DOI Creative Commons
Katsuhiko Ariga

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Nanoarchitectonics, as a post‐nanotechnology concept, represents methodology for the construction of functional materials employing atoms, molecules, and nanomaterials essential components. The overarching objective nanoarchitectonics is to develop systems comprising multiple units assembled in hierarchical manner, observed biological systems. Nevertheless, such challenging endeavor. It would be prudent, therefore, initially focus on development that interact with complex structures living organisms. Accordingly, this review article addresses topic nanoarchitecture it pertains biomedical applications. This examines current trends research presents examples studies support concept its applications fields. presented are follows: i) molecular developments, which mainly based design assembly; ii) material examples, using components; iii) porous materials, will summarized under heading pore‐engineered due their special structure. Finally, provides an overview these discusses future prospects.

Language: Английский

Citations

2
Spatially Variable Genes DOI

Shantagoud Biradar,

Chaaya Suresh,

Nagashri Nanjundeshwara

et al.

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 28

Published: Dec. 17, 2024

The clinical translation of spatial transcriptomics represents cancer diagnosis and therapy based on the role heterogeneity cancer-associated fibroblasts (CAFs) within tumor microenvironment (TME). Recent developments in have enabled a detailed characterization organization cellular interactions tumors. data integration, multi-omics approaches, along with developing standardized protocols is essential for effective translation. experimental selection regimes factorial designs reveals novel insights into biomarkers prognostic value CAFs. incorporation optogenetics advancements bio-engineered gene circuits, therapeutics tissue engineering further underscores potential to refine patient stratification improve treatment responsiveness. By integrating workflows, this work aims advance personalized therapies biology.

Language: Английский

Citations

0