Unveiling the Therapeutic Potential of Paclitaxel Combinations Against Breast Carcinoma and Identification of In Vivo Biomarkers

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 104(3)

Published: Sept. 1, 2024

Breast cancer (BC) is one of the leading causes high mortality rates in women worldwide. Although advancements have been made design therapeutic strategies and drug discovery, resistance remains key challenges. One ways to overcome finding potential combinations since efficacy combined drugs higher than their individual efficacies if combination a synergistic pair. Therefore, current study uses BC patient-derived xenograft (PDX) dataset evaluate effects various on breast vivo models. The are further validated by four machine learning models, namely Elastic Net, Least Absolute Shrinkage Selection (LASSO), Support Vector Machine (SVM), Random Forests (RF), as well exploring shortlisted with paclitaxel, baseline for enhanced tumor volume reduction. Additionally, also shortlists top 50 biomarkers correlated drugs. outcomes could be significantly important an effective anti-breast therapy.

Language: Английский

Aripiprazole-loaded niosome/chitosan-gold nanoparticles for breast cancer chemo-photo therapy

BMC Biotechnology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 24, 2024

Breast cancer, a formidable global health challenge for women, necessitates innovative therapeutic strategies with enhanced efficacy and minimal side effects. Aripiprazole (ARI), widely used schizophrenia medication, exhibits promising potential in the treatment of breast cancer. As cancer therapy evolves towards combination approach, multimodal nano-based delivery systems, such as ARI-loaded niosomes (NIOs) combined Chitosan-Au nanoparticles chemo-photothermal therapy, show promise over traditional chemotherapy alone by enhancing targeted minimizing In this study, niosomal formulation was designed, incorporating ARI chitosan-coated AuNPs (i.e. NIOs/AuNPs-CS/ARI), to study synergistic effect photothermal/chemotherapy cells. The nanosystems were characterized using UV-Vis spectroscopy Fourier-transform infrared (FT-IR), confirming successful synthesis steps. hydrodynamic diameter NIOs/AuNPs-CS determined be 44.62 nm zeta -0.836. Also, Transmission Electron Microscopy (TEM) Field-Emission Scanning Microscopical (FE-SEM) analysis performed assess size morphology NPs. loading efficiency NIOs NIOs/AuNPs–CS 75% 88%, respectively. Furthermore, release rate drug from is higher than blank at two pH values (5.8 7.4). cellular uptake AuNPs-CS-encapsulated considerably that NIOs. Annexin V/PI staining assay showed apoptosis/necrosis high NIOs/AuNPs-CS/ARI (46%) NIOs/ARI (36%) 48 h. results MTT assessments demonstrated cytotoxicity viability MCF-7 cells treated reduced 60% 50% 40% 20%, respectively, after 24 h upon laser irradiation. experiment remarkable effectiveness treatment, owing their unique properties, including PTT capability sensitivity.

Language: Английский

Research progress of paclitaxel nanodrug delivery system in the treatment of triple-negative breast cancer

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101358 - 101358

Published: Nov. 23, 2024

Language: Английский