Clinical and Therapeutic Potential of Bacillus subtilis Antimicrobial Peptides DOI
Sajid Iqbal,

Mehwish Malik,

Bushra Mustafa

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

The bioactive peptides produced by Bacillus subtilis have garnered significant attention for their diverse bioactivities and promising therapeutic applications. These exhibit broad-spectrum activity against bacterial, viral, fungal, parasitic infections, making them potent candidates treating drug-resistant pathogens. Further, these exhibited anticancer selectively targeting cancer cells, inducing apoptosis, inhibiting tumor cell migration invasion. Beyond direct antimicrobial properties, B. also possess immunomodulatory effects, enhancing host immune responses reducing inflammation. This dual role in both pathogen elimination regulation expands potential, particularly use chronic infections wound healing. To prevent from hydrolysis, biomaterial liposome delivery systems been designed to improve the stability bioavailability of peptides. key challenge peptide-based drug discovery is accurate prediction peptide functionality stability, given complexity interactions with biological targets. Machine learning algorithms can be employed design optimized properties accelerate identification novel enhanced efficacy specificity. Overall, this chapter demonstrates mechanisms action, applications,

Language: Английский

Incorporation of Ceragenins into Medical Adhesives and Adhesive Scar Tape to Prevent Microbial Colonization Common in Healthcare-Associated Infections DOI Creative Commons

Aaron Zaugg,

Elliot Sherren,

Rebekah Yi

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(11), P. 1002 - 1002

Published: Oct. 24, 2024

Healthcare-associated infections involving surgical sites, skin trauma, and devices penetrating the are a frequent source of increased expense, hospitalization periods, adverse outcomes. Medical adhesives often employed to help protect compromised from infection secure medical devices, but can become contaminated by pathogens, exposing wounds, colonization. We aimed incorporate ceragenins, class antimicrobial agents, into silicone- polyacrylate-based with goal reducing adhesive contamination subsequent infections.

Language: Английский

Citations

0
Clinical and Therapeutic Potential of Bacillus subtilis Antimicrobial Peptides DOI
Sajid Iqbal,

Mehwish Malik,

Bushra Mustafa

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

The bioactive peptides produced by Bacillus subtilis have garnered significant attention for their diverse bioactivities and promising therapeutic applications. These exhibit broad-spectrum activity against bacterial, viral, fungal, parasitic infections, making them potent candidates treating drug-resistant pathogens. Further, these exhibited anticancer selectively targeting cancer cells, inducing apoptosis, inhibiting tumor cell migration invasion. Beyond direct antimicrobial properties, B. also possess immunomodulatory effects, enhancing host immune responses reducing inflammation. This dual role in both pathogen elimination regulation expands potential, particularly use chronic infections wound healing. To prevent from hydrolysis, biomaterial liposome delivery systems been designed to improve the stability bioavailability of peptides. key challenge peptide-based drug discovery is accurate prediction peptide functionality stability, given complexity interactions with biological targets. Machine learning algorithms can be employed design optimized properties accelerate identification novel enhanced efficacy specificity. Overall, this chapter demonstrates mechanisms action, applications,

Language: Английский

Citations

0