International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125078 - 125078
Published: Dec. 1, 2024
Language: Английский
Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
1
AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(7)
Published: Oct. 8, 2024
Abstract This review investigates the progression and effectiveness of colon-targeted drug delivery systems, offering a comprehensive understanding colon's anatomy physiological environment. Recognizing distinctive features colon is crucial for successfully formulating oral dosage forms that precisely target specific areas in gastrointestinal tract (GIT) while minimizing side effects through mitigating off-target sites. basis designing effective targeted systems. The article extensively examines diverse approaches to drugs colonic targeting, highlighting key polymers excipients their production. Special emphasis given innovative such as hot-melt extrusion (HME) three-dimensional printing (3D-P), renowned accuracy release kinetics intricate form geometry. However, challenges arise regarding material standardization complex network regulatory clearances required confirm safety effectiveness. provides insights into each application’s advantages potential challenges. Furthermore, it sheds light on local diseases necessitate targeting available marketed products, providing an overview current state Additionally, emphasizes importance testing controlled vitro environment during development phase. It also discusses future directions successful this field. By integrating knowledge across anatomy, formulation techniques, assessment methodologies, valuable resource researchers navigating dynamic field delivery. Graphical
Language: Английский
Citations
4
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 413 - 413
Published: March 25, 2025
Background/Objectives: This study aimed to develop and evaluate taste-masked theophylline pellets using hot-melt extrusion (HME) technology. Additionally, the evaluates efficacy of various taste-masking polymers by comparing three pH-dependent polymers, Kollicoat® Smartseal 100P, Eudragit® EPO, MAE 100-55, in masking taste optimizing drug release. Methods: Formulations were designed with varying loads (10%, 20%, 30%) plasticizer concentrations (20% 30% PEG 1500). Lead formulations characterized differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), bitter threshold level, vitro release testing. Stability was assessed under accelerated conditions (40 °C ± 2 75% 5% RH) for months. Results: DSC confirmed homogenous dispersion within polymer matrix. The optimized formulation comprising 20% theophylline, 1500, 60% 100P demonstrated effective masking, releasing only 1.1% simulated salivary fluid (SSF) two minutes, significantly lower than pure (29.5%, p < 0.05), 100-55 (2.8%, comparable EPO (2.1%, > 0.05). Solubility studies further that from lead remained well below its reported threshold, which could prevent perception mitigate bitterness. In gastric fluid, complete achieved while exhibited limited showed maintained texture, efficacy, dissolution profile conditions. Conclusions: demonstrates novel exploration HME application, effectiveness achieving robust improving patient compliance, particularly pediatric geriatric populations.
Language: Английский
Citations
0
AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(4)
Published: March 27, 2025
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125078 - 125078
Published: Dec. 1, 2024
Language: Английский
Citations
0