Nanoengineered Microneedles: A Versatile Targeted Delivery System for Theragnostic Applications

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Microneedles (MNs) have been used as active drug delivery carriers by precisely delivering drugs to the targeted site along with minimal tissue destruction. Earlier, MNs were for of transdermal site; now they are solid tumor site, mucosal, ophthalmic, and other organ site-specific delivery. considered a boon trans-barrier because routes, such systemic parenteral, face challenges limiting optimum amount reaching skin or barrier-containing organs. Hence, MN-mediated enhances permeation improves brain ciliary nasal clearance crossing barrier. The current book chapter mainly focuses on recent advancements in area MN-based into various parts body, their theragnostic applications, organs containing barriers, encounters has discussed. Also, comprehensive overview MN types, fabrication polymers, mechanisms release, effectiveness, advantages over conventional systems summarized.

Language: Английский

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Implication of Microneedle for Ocular Delivery System

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 98, P. 105841 - 105841

Published: June 5, 2024

Language: Английский

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Leveraging Nanoengineered Microneedle‐Augmented Drug Delivery in Oncological Intervention

Particle & Particle Systems Characterization, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Abstract The landscape of chemotherapy for cancer is experiencing a dramatic transition with the integration sophisticated drug delivery methods, especially nanoengineered microneedles. Percutaneous vaccination regarded optimum therapeutic approach due to high amount immune cell accumulation and rich capillary lymphatic system in dermis. curative impact Microneedles‐based vaccines suboptimal complicated mix tumor, host, environmental variables, as well vaccine's restricted loading capacity. As result, additional enhancements are still needed accelerate their clinical translation. This article offers meticulous analysis avant‐garde strategies harnessed augment via microneedle. Various tactics, such tailored nanoparticle carriers, functionalized microneedle arrays, real‐time monitoring system, work together improve efficacy prevent off‐target effects. By integrating recent advancement delineating future trajectories, this gives an in‐depth how microneedle‐augmented technologies have potential change face therapy, heralding new era precision medicine better outcomes.

Language: Английский

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Nanosystems - Combination products

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 141 - 163

Published: Oct. 1, 2024

Language: Английский

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