Graphene-Oxide Peptide-Containing Materials for Biomedical Applications

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10174 - 10174

Published: Sept. 22, 2024

This review explores the application of graphene-based materials (GBMs) in biomedicine, focusing on graphene oxide (GO) and its interactions with peptides proteins. GO, a versatile nanomaterial oxygen-containing functional groups, holds significant potential for biomedical applications but faces challenges related to toxicity environmental impact. Peptides proteins can be functionalized GO surfaces through various methods, including non-covalent such as π–π stacking, electrostatic forces, hydrophobic interactions, hydrogen bonding, van der Waals well covalent bonding reactions involving amide bond formation, esterification, thiol chemistry, click chemistry. These approaches enhance GO’s functionality several key areas: biosensing sensitive biomarker detection, theranostic imaging that integrates diagnostics therapy real-time treatment monitoring, targeted cancer where deliver drugs directly tumor sites while being tracked by techniques like MRI photoacoustic imaging. Additionally, GO-based scaffolds are advancing tissue engineering aiding tissues’ bone, muscle, nerve regeneration, their antimicrobial properties improving infection-resistant medical devices. Despite potential, addressing stability scalability is essential fully harness benefits GBMs healthcare.

Language: Английский

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Preparation, characterization, and in vitro release studies of multifunctional nanoformulations designed by functionalized graphene nanosheets with natural compounds

FlatChem, Journal Year: 2025, Volume and Issue: unknown, P. 100824 - 100824

Published: Jan. 1, 2025

Language: Английский

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Processing of chitosan scaffolds containing graphene oxide for developing drug delivery module

Materials and Manufacturing Processes, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Feb. 17, 2025

Hydrogel scaffolds are networks of three-dimensional polymers that may expand, retain the ability to absorb water 50 times their dry weight. These hydrogel can be tailored various sizes and forms by using freeze-drying method, which directly extends shelf life, preventing chemical microbiological reactions. Chitosan-based 3D popularly used as drug delivery platforms due swelling biocompatibility properties. When paired with polymers, graphene oxide(GO)- a surface-active material, exhibits superior antibacterial property controlled/sustained drug-release. The creation oxide how characteristics alter different CS covered in this paper. A UV-visible spectrophotometer was examine loaded cefotaxime individually release it PBS pH 7.4. COMSOL MULTIPHYSICS 6.2 software implemented transport diluted species porous catalyst component, indicating sustained release.

Language: Английский

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Curcumin@ graphene oxide/chitosan/arginine hydrogel: A novel approach to treat Candida periprosthetic joint infections

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141966 - 141966

Published: March 1, 2025

Language: Английский

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Synthesis and characterization of self-crosslinked carboxymethyl chitosan-based hydrogel and its composites with gelatin and PEG-GO for drug delivery applications

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142256 - 142256

Published: March 1, 2025

Language: Английский

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Bioengineered carbohydrate polymers for colon‐specific drug release: Current trends and future prospects

Journal of Biomedical Materials Research Part A, Journal Year: 2024, Volume and Issue: 112(11), P. 1860 - 1872

Published: May 9, 2024

Abstract The worldwide health burden of colorectal cancer is still substantial, and traditional chemotherapeutic drugs sometimes have poor selectivity, which can result in systemic toxicity unfavorable side effects. For colon‐specific medication delivery, bioengineered carbohydrate polymers shown promise as carriers. They may enhance treatment effectiveness while minimizing exposure associated unique properties these manufactured or naturally occurring biopolymers, such hyaluronic acid, chitosan, alginate, pectin, enable targeted medicine release. These qualities be changed to meet the physiological needs colon. In context therapy, this article provides a comprehensive overview current developments prospective future directions field polymer synthesis for drug delivery. We discuss numerous techniques achieving colon‐targeted release, including enzyme‐sensitive polymers, pH‐responsive devices, microbiota‐activated processes. To increase tumor selectivity cellular uptake, we also examine inclusion active targeting approaches, conjugating specific ligands. Furthermore, potential combination strategies, use coadministration therapeutic medications target multiple pathways implicated growth address resistance mechanisms. recent biomimetic advances that potentially improve biocompatibility, penetration polymer‐based nanocarriers. methods involve protein corona engineering cell membrane coating. look at possibility intelligent sensitive systems adjust their behaviors response certain inputs feedback loops, allowing precise regulated distribution.

Language: Английский

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Antioxidants accelerate the Fe(III)/Fe(II) cycle for the degradation of ofloxacin

Journal of Materials Science, Journal Year: 2024, Volume and Issue: 59(42), P. 19811 - 19824

Published: Oct. 27, 2024

Language: Английский

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Synthesis of Graphene Oxide Shielded Highly Stable Nano Liposomes for Intestinal Delivery of CoQ10

BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 2, 2024

Language: Английский

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