Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities
Cancers,
Journal Year:
2025,
Volume and Issue:
17(4), P. 701 - 701
Published: Feb. 19, 2025
Glioblastoma
multiforme
(GBM)
is
a
highly
malignant
brain
tumor
that
has
bleak
outlook
despite
existing
treatments
such
as
surgery,
radiation,
and
chemotherapy.
The
utilization
of
nanoparticles
for
drug
delivery
presents
promising
method
by
which
to
improve
the
effectiveness
treatment
while
reducing
harmful
effects
on
entire
body.
This
review
examines
application
in
GBM,
focusing
different
types
nanoparticles,
including
lipid-based,
polymeric,
metallic,
those
under
development.
Every
variety
analyzed
its
distinct
characteristics
therapeutic
capacity.
Lipid-based
liposomes
solid
lipid
enhance
transport
medicines
are
not
soluble
water
have
shown
considerable
potential
preclinical
investigations.
Polymeric
benefits
terms
controlled
release
targeted
distribution,
whereas
metallic
both
therapy
imaging.
In
current
we
would
like
emphasize
ways
medicine
delivery,
specifically
enhancing
penetration
blood-brain
barrier
(BBB),
targeting
tumors,
enabling
release.
Additionally,
also
discuss
clinical
discoveries,
highlighting
achievements
obstacles
process
converting
these
technologies
into
effective
GBM.
study
offers
thorough
examination
present
status
prospects
Language: Английский
Smart Poly(N-isopropylacrylamide)-Based Hydrogels: A Tour D’horizon of Biomedical Applications
Soumya Narayana,
No information about this author
B.H. Jaswanth Gowda,
No information about this author
Umme Hani
No information about this author
et al.
Gels,
Journal Year:
2025,
Volume and Issue:
11(3), P. 207 - 207
Published: March 15, 2025
Hydrogels
are
innovative
materials
characterized
by
a
water-swollen,
crosslinked
polymeric
network
capable
of
retaining
substantial
amounts
water
while
maintaining
structural
integrity.
Their
unique
ability
to
swell
or
contract
in
response
environmental
stimuli
makes
them
integral
biomedical
applications,
including
drug
delivery,
tissue
engineering,
and
wound
healing.
Among
these,
“smart”
hydrogels,
sensitive
such
as
pH,
temperature,
light,
showcase
reversible
transitions
between
liquid
semi-solid
states.
Thermoresponsive
exemplified
poly(N-isopropylacrylamide)
(PNIPAM),
particularly
notable
for
their
sensitivity
temperature
changes,
transitioning
near
lower
critical
solution
(LCST)
approximately
32
°C
water.
Structurally,
PNIPAM-based
hydrogels
(PNIPAM-HYDs)
chemically
versatile,
allowing
modifications
that
enhance
biocompatibility
functional
adaptability.
These
properties
enable
application
diverse
therapeutic
areas
cancer
therapy,
phototherapy,
healing,
engineering.
In
this
review,
the
behavior
smart
PNIPAM
explored,
with
an
emphasis
on
synthesis
methods
brief
note
biocompatibility.
Furthermore,
PNIPAM-HYDs
detailed,
along
applications
skin
conditions,
ocular
diseases,
etc.
Various
delivery
routes
patents
highlighting
advancements
also
examined.
Finally,
future
prospects
remain
promising,
ongoing
research
focused
enhancing
stability,
responsiveness,
clinical
applicability.
continued
development
is
expected
revolutionize
technologies,
paving
way
more
efficient
targeted
solutions.
Language: Английский
Synthesis and characterization of a new smart magnetic nanocarrier for drug delivery
Inorganic Chemistry Communications,
Journal Year:
2025,
Volume and Issue:
unknown, P. 114378 - 114378
Published: March 1, 2025
Language: Английский
Gold nanoparticle-enabled doxorubicin delivery: Advancing targeted chemotherapy in cancer therapy
Rishabh Aggarwal,
No information about this author
Ayaz Ahmed,
No information about this author
B.H. Jaswanth Gowda
No information about this author
et al.
Inorganic Chemistry Communications,
Journal Year:
2025,
Volume and Issue:
unknown, P. 114467 - 114467
Published: April 1, 2025
Language: Английский
Unveiling the potential of photodynamic therapy with nanocarriers as a compelling therapeutic approach for skin cancer treatment: current explorations and insights
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(30), P. 21915 - 21937
Published: Jan. 1, 2024
Skin
carcinoma
is
one
of
the
most
prevalent
types
carcinomas.
Due
to
high
incidence
side
effects
in
conventional
therapies
(radiotherapy
and
chemotherapy),
photodynamic
therapy
(PDT)
has
gained
huge
attention
as
an
alternate
treatment
strategy.
PDT
involves
administration
photosensitizers
(PS)
cells
which
produce
reactive
oxygen
species
(ROS)
on
irradiation
by
specific
wavelengths
light
that
result
cancer
cells'
death
Language: Английский
Microneedles as an Emerging Platform for Transdermal Delivery of Phytochemicals
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 29, 2024
Phytochemicals,
which
are
predominantly
found
in
plants,
hold
substantial
medicinal
value.
Despite
their
potential,
challenges
such
as
poor
oral
bioavailability
and
instability
the
gastrointestinal
tract
have
limited
therapeutic
use.
Traditional
intra/transdermal
drug
delivery
systems
offer
some
advantages
over
administration
but
still
suffer
from
issues
penetration
depth,
slow
release
rates,
inconsistent
absorption.
In
contrast,
microneedles
(MNs)
represent
a
significant
advancement
by
providing
precise
control
phytochemical
enhanced
capabilities.
By
circumventing
skin
barriers,
MNs
directly
access
dermal
layers
rich
blood
vessels
lymphatics,
thus
facilitating
efficient
delivery.
This
review
extensively
discusses
obstacles
of
traditional
benefits
routes
with
particular
focus
on
transformative
potential
for
explores
complexities
delivering
phytochemicals
through
routes,
development
types
innovative
tools,
optimal
design
properties
effective
Additionally,
this
examines
versatile
applications
MN-mediated
delivery,
including
its
role
administering
phytophotosensitizers
photodynamic
therapy,
concludes
insights
into
relevant
patents
future
perspectives.
Language: Английский
Active-targeting pH/temperature-responsive magnetic nanocarriers based on poly(N-isopropylacrylamide) and spermine-dendronized magnetite nanoparticles for controlled cyclophosphamide delivery
Journal of Molecular Structure,
Journal Year:
2024,
Volume and Issue:
1328, P. 141288 - 141288
Published: Dec. 31, 2024
Language: Английский