Evaluating silver nanoparticles, copper coatings, and zinc oxide nanostructures for antimicrobial medical device applications DOI Creative Commons
Priyeshkumar Thangavel Anandapillai,

Samudram Manickam Kamali,

V. Malathy

et al.

Matéria (Rio de Janeiro), Journal Year: 2024, Volume and Issue: 29(4)

Published: Jan. 1, 2024

ABSTRACT The increase in hospital-acquired infections (HAIs) associated with medical devices underscores the need for antimicrobial coatings. This study aims to compare efficacy, biocompatibility, ion release, and durability of silver nanoparticles, copper coatings, zinc oxide nanostructures as coatings devices. Coatings were prepared characterized, efficacy tested against E. coli S. aureus via inhibition zone measurements. Silver demonstrated highest effect, zones averaging 90%, while showed moderate 80% 70%, respectively. Biocompatibility, assessed using human fibroblasts an MTT assay, cell viability oxide, followed by silver. Durability tests under simulated physiological conditions indicated that retained over 90% structural integrity, greater degradation. Ion release profiles highlighted silver’s rapid ideal short-term activity, steady, sustained release. These findings suggest immediate infection control, offer balanced long-term safety durability, making them suitable extended applications

Language: Английский

Evaluating silver nanoparticles, copper coatings, and zinc oxide nanostructures for antimicrobial medical device applications DOI Creative Commons
Priyeshkumar Thangavel Anandapillai,

Samudram Manickam Kamali,

V. Malathy

et al.

Matéria (Rio de Janeiro), Journal Year: 2024, Volume and Issue: 29(4)

Published: Jan. 1, 2024

ABSTRACT The increase in hospital-acquired infections (HAIs) associated with medical devices underscores the need for antimicrobial coatings. This study aims to compare efficacy, biocompatibility, ion release, and durability of silver nanoparticles, copper coatings, zinc oxide nanostructures as coatings devices. Coatings were prepared characterized, efficacy tested against E. coli S. aureus via inhibition zone measurements. Silver demonstrated highest effect, zones averaging 90%, while showed moderate 80% 70%, respectively. Biocompatibility, assessed using human fibroblasts an MTT assay, cell viability oxide, followed by silver. Durability tests under simulated physiological conditions indicated that retained over 90% structural integrity, greater degradation. Ion release profiles highlighted silver’s rapid ideal short-term activity, steady, sustained release. These findings suggest immediate infection control, offer balanced long-term safety durability, making them suitable extended applications

Language: Английский

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