Bioconjugate Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 6, 2024
Poly(amidoamine)
(PAMAM)
dendrimers
have
gained
significant
attention
in
various
research
fields,
particularly
medicinal
compound
delivery.
Their
versatility
lies
their
ability
to
conjugate
with
functional
molecules
on
surfaces
and
encapsulate
small
molecules,
making
them
suitable
for
diverse
applications.
Gallic
acid
is
a
potent
antioxidant
that
has
garnered
considerable
interest
recent
years.
Our
aims
investigate
if
the
gallic
acid-encapsulated
PAMAM
dendrimer
generations
4
(G4(OH)-Ga)
5
(G5(OH)-Ga)
could
enhance
radical
scavenging,
which
potentially
slow
down
progression
of
age-related
macular
degeneration
(AMD).
Encapsulation
feasible
alternative
prevent
its
degradation
toxicity.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(18), P. 4293 - 4293
Published: Sept. 10, 2024
In
this
study,
we
hypothesized
that
biotinylated
and/or
glycidol-flanked
fourth-generation
polyamidoamine
(PAMAM
G4)
dendrimers
could
be
a
tool
for
efficient
drug
transport
into
glioma
and
liver
cancer
cells.
For
purpose,
native
PAMAM
(G4)
dendrimers,
(G4B),
glycidylated
(G4gl),
(G4Bgl),
were
synthesized,
their
cytotoxicity,
uptake,
accumulation
in
vitro
vivo
studied
relation
to
the
mediated
by
sodium-dependent
multivitamin
transporter
(SMVT).
The
studies
showed
human
temozolomide-resistant
cell
line
(U-118
MG)
hepatocellular
carcinoma
(HepG2)
indicated
higher
amount
of
SMVT
than
HaCaT
keratinocytes
(HaCaTs)
used
as
model
normal
G4gl
G4Bgl
highly
biocompatible
(they
did
not
affect
proliferation
mitochondrial
activity)
against
U-118
MG
cells
(against
Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: Oct. 14, 2024
Abstract
Transfection
efficiency
is
a
critical
parameter
in
gene
therapy
and
molecular
biology,
representing
the
success
rate
at
which
nucleic
acids
are
introduced
expressed
target
cells.
The
combination
of
aptamers
with
nanotechnology‐based
delivery
systems
has
demonstrated
remarkable
improvements
transfection
therapeutic
agents
holds
significant
potential
for
advancing
development
targeted
treatments
various
diseases,
including
cancer.
In
this
work,
cationic
carbosilane
dendritic
presented
as
an
alternative
to
commercial
agents,
demonstrating
increase
when
used
internalization
apMNKQ2,
aptamer
selected
against
Their
use
been
evaluated
breast
cancer
cell
lines,
MDA‐MB‐468
MDA‐MB‐231,
studying
cytotoxicity
nanoconjugate,
process,
its
effect
on
cellular
migration
processes.
MOLECULAR SCIENCES AND APPLICATIONS,
Journal Year:
2024,
Volume and Issue:
4, P. 117 - 124
Published: Nov. 11, 2024
In
previous
papers,
we
studied
the
behavior
of
lysine
(Lys
or
K)
based
dendrimers
second
generation
with
repeating
units
KKK
and
KRR
(i.e.,
branched
neutral
charged
double
arginine
(KK,
RR)
spacers).
We
also
KLL,
KAA,
KGG
hydrophobic
leucine,
alanine,
glycine
(LL,
AA,
GG)
spacers
pH-dependent
KHH
histidine
(HH)
spacers.
Their
complexes
molecules
several
medicinal
peptides
(including
AEDG)
were
as
well.
It
was
shown
that
are
suitable
for
delivery
oppositely
oligopeptides
genetic
material,
while
internal
good
fullerenes.
present
paper,
study
AEDG
peptide
KRH
dendrimer
containing
arginine-histidine
(RH)
this
case,
amino
acid
residues
in
spacer
(R
H)
different,
charge
H
residue
depends
on
pH.
performed
molecular
dynamics
simulations
complexation
16
a
at
two
different
pHs:
a)
pH>7
fully
uncharged
histidines
(H)
b)
KRHp
pH<5
protonated
(Hp)
aqueous
solution
explicit
counterions.
found
forms
more
compact
complex.
can
carry
tetrapeptide
than
KRH.
Bioconjugate Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 6, 2024
Poly(amidoamine)
(PAMAM)
dendrimers
have
gained
significant
attention
in
various
research
fields,
particularly
medicinal
compound
delivery.
Their
versatility
lies
their
ability
to
conjugate
with
functional
molecules
on
surfaces
and
encapsulate
small
molecules,
making
them
suitable
for
diverse
applications.
Gallic
acid
is
a
potent
antioxidant
that
has
garnered
considerable
interest
recent
years.
Our
aims
investigate
if
the
gallic
acid-encapsulated
PAMAM
dendrimer
generations
4
(G4(OH)-Ga)
5
(G5(OH)-Ga)
could
enhance
radical
scavenging,
which
potentially
slow
down
progression
of
age-related
macular
degeneration
(AMD).
Encapsulation
feasible
alternative
prevent
its
degradation
toxicity.
