Optimising the viscoelastic properties of hyaluronic acid hydrogels through colloidal particle interactions: a response surface methodology approach DOI Creative Commons
Giriprasath Ramanathan,

Masroora Hassan,

Yury Rochev

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Abstract Enhancing the viscoelastic characteristics of hydrogel systems through strategic colloidal particle interactions is paramount for their functionality in rectal gel applications. This investigation delves into synergistic between cationic nanoparticles (CNPs), anionic (ANPs), and composite (NPs) within a hyaluronic acid (HA) matrix, employing response surface methodology (RSM) optimisation. Critical parameters, namely volume fraction NPs oscillatory amplitude, were meticulously calibrated to achieve optimal complex viscosity, as determined by advanced rheometric analysis. The findings reveal substantial effects CNPs, ANPs, mixed on viscoelasticity HA hydrogel, with viscosity measurements 490.82 ± 10.57, 214.70 8.96, 328.46 6.67 mPa·s, respectively. system exhibited strong concordance empirical data (R² = 0.9843), validating predictive precision model. Morphological assessments uncovered highly interconnected network gel-particle composite, characterised both densely sparsely packed porous architectures. study presents robust framework modulating properties particle-gel systems, providing pivotal insights development formulations.

Language: Английский

Chitosan-coated nanostructured lipid carriers for intranasal delivery of sinapic acid in Aβ1–42 induced C57BL/6 mice for Alzheimer's disease treatment DOI

A Prabakaran,

Debarati Rakshit,

Inklisan Patel

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141136 - 141136

Published: Feb. 1, 2025

Language: Английский

Citations

1
Innovative approaches in breast cancer therapy: repurposing nanocarriers for enhanced outcomes DOI

Sana Naaz Siddiqui,

Md. Faheem Haider, M.A. Rahman

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Enhanced cognitive function in mice through intranasal delivery of sinapic acid via chitosan-coated solid lipid nanoparticles DOI

A Prabakaran,

Debarati Rakshit,

Inklisan Patel

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 675, P. 125565 - 125565

Published: April 1, 2025

Language: Английский

Citations

0
Double-Edged Sword Effect of Diet and Nutrition on Carcinogenic Molecular Pathways in Breast Cancer DOI Open Access

Anca-Narcisa Neagu,

Claudiu-Laurentiu Josan,

Taniya Jayaweera

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11078 - 11078

Published: Oct. 15, 2024

Environmental exposure to a mixture of chemical xenobiotics acts as double-edged sword, promoting or suppressing tumorigenesis and the development breast cancer (BC). Before anything else, we are what eat. In this review, highlight both “the good” bad” sides daily human diet dietary patterns that could influence BC risk (BCR) incidence. Thus, regularly eating new, diversified, colorful, clean, nutrient-rich, energy-boosting, raw food, increases apoptosis autophagy, antioxidation, cell cycle arrest, anti-inflammation, immune response against cells. Moreover, healthy lead reduction in inhibition genomic instability, stemness, growth, proliferation, invasion, migration, distant metastasis. We also emphasize that, addition beneficial compounds, our food is more contaminated by chemicals with harmful effects, which interact each other endogenous proteins lipids, resulting synergistic antagonistic effects. diverse diet, combined appropriate nutritional behaviors, can exert anti-carcinogenic effects improve treatment efficacy, patient outcomes, overall quality life patients.

Language: Английский

Citations

2
Optimising the viscoelastic properties of hyaluronic acid hydrogels through colloidal particle interactions: a response surface methodology approach DOI Creative Commons
Giriprasath Ramanathan,

Masroora Hassan,

Yury Rochev

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 703, P. 135320 - 135320

Published: Sept. 10, 2024

Language: Английский

Citations

1
Impact of PEGylated liposomes on cytotoxicity of tamoxifen and piperine on MCF-7 human breast carcinoma cells DOI

Klaudi K. Vaiphei,

A Prabakaran,

Shikha Snigdha

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 102, P. 106331 - 106331

Published: Oct. 25, 2024

Language: Английский

Citations

1
Optimising the viscoelastic properties of hyaluronic acid hydrogels through colloidal particle interactions: a response surface methodology approach DOI Creative Commons
Giriprasath Ramanathan,

Masroora Hassan,

Yury Rochev

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Abstract Enhancing the viscoelastic characteristics of hydrogel systems through strategic colloidal particle interactions is paramount for their functionality in rectal gel applications. This investigation delves into synergistic between cationic nanoparticles (CNPs), anionic (ANPs), and composite (NPs) within a hyaluronic acid (HA) matrix, employing response surface methodology (RSM) optimisation. Critical parameters, namely volume fraction NPs oscillatory amplitude, were meticulously calibrated to achieve optimal complex viscosity, as determined by advanced rheometric analysis. The findings reveal substantial effects CNPs, ANPs, mixed on viscoelasticity HA hydrogel, with viscosity measurements 490.82 ± 10.57, 214.70 8.96, 328.46 6.67 mPa·s, respectively. system exhibited strong concordance empirical data (R² = 0.9843), validating predictive precision model. Morphological assessments uncovered highly interconnected network gel-particle composite, characterised both densely sparsely packed porous architectures. study presents robust framework modulating properties particle-gel systems, providing pivotal insights development formulations.

Language: Английский

Citations

0